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The influence of parathyroid hormone 1-34 on the osteogenic characteristics of adipose- and bone-marrow-derived mesenchymal stem cells from juvenile and ovarectomized rats

Osagie-Clouard, L; Sanghani-Kerai, A; Coathup, M; Meeson, R; Briggs, T; Blunn, G

Authors

L Osagie-Clouard

A Sanghani-Kerai

M Coathup

R Meeson

T Briggs

G Blunn



Abstract

Mesenchymal stem cells (MSCs) are of growing interest in terms of bone regeneration. Most preclinical trials utilize bone-marrow-derived mesenchymal stem cells (bMSCs), although this is not without isolation and expansion difficulties. The aim of this study was: to compare the characteristics of bMSCs and adipose-derived mesenchymal stem cells (AdMSCs) from juvenile, adult, and ovarectomized (OVX) rats; and to assess the effect of human parathyroid hormone (hPTH) 1-34 on their osteogenic potential and migration to stromal cell-derived factor-1 (SDF-1).

Citation

Osagie-Clouard, L., Sanghani-Kerai, A., Coathup, M., Meeson, R., Briggs, T., & Blunn, G. (2019). The influence of parathyroid hormone 1-34 on the osteogenic characteristics of adipose- and bone-marrow-derived mesenchymal stem cells from juvenile and ovarectomized rats. https://doi.org/10.1302/2046-3758.88.BJR-2019-0018.R1

Journal Article Type Article
Acceptance Date Aug 2, 2019
Publication Date Aug 23, 2019
Deposit Date Mar 4, 2020
Publicly Available Date Mar 4, 2020
Journal Bone and Joint Research
Peer Reviewed Peer Reviewed
Volume 8
Issue 8
Pages 397-404
DOI https://doi.org/10.1302/2046-3758.88.BJR-2019-0018.R1
Public URL https://rvc-repository.worktribe.com/output/1380785

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