THE INFLUENCE OF AGEING IN TENDON HOMEOSTASIS AND THE RISK OF TENDON INJURY
Presentation / Conference Contribution
Smith, R. K. W., Dudhia, J., Scott, C. M., Draper, E., May, S. A., & Pitsillides, A. A. THE INFLUENCE OF AGEING IN TENDON HOMEOSTASIS AND THE RISK OF TENDON INJURY. International Journal of Experimental Pathology, 89(3), A25-A25
All Outputs (144)
Mesenchymal stem cell therapy for equine tendinopathy
Journal Article
Smith, R. K. W. Mesenchymal stem cell therapy for equine tendinopathy. Disability and Rehabilitation, 30(20-22), 1752-1758. https://doi.org/10.1080/09638280701788241Optimal management of tendon overuse injuries in equine and human athletes should avoid the formation of excessive scar tissue, regenerate normal tendon matrix, and reduce re-injury rates. We hypothesized that the implantation of marrow-derived strom... Read More about Mesenchymal stem cell therapy for equine tendinopathy.
Principles of stem cell therapy in the horse - the science behind the technology
Journal Article
Smith, R. K. W. Principles of stem cell therapy in the horse - the science behind the technologyTendon and ligament overstrain injuries in the horse are appropriate diseases to consider for stem cell therapy because normal fibrous repair results in reduced functionality, typified by poorer performance and a high rate of re-injury. Exogenously a... Read More about Principles of stem cell therapy in the horse - the science behind the technology.
Stem cell therapy for tendon and ligament injuries in the horse - technique and outcome
Journal Article
Smith, R. K. W. Stem cell therapy for tendon and ligament injuries in the horse - technique and outcomeThe technique involves the collection of bone marrow from the sternum in the standing sedated horse, followed by isolation and expansion of the nucleated adherent cell population (containing the MSCs) in the laboratory. After approximately 2-3 weeks,... Read More about Stem cell therapy for tendon and ligament injuries in the horse - technique and outcome.
Intratendinous treatments - are they innocuous?
Journal Article
Smith, R. K. W. Intratendinous treatments - are they innocuous?. Equine Veterinary Education, 20(7), 392-392. https://doi.org/10.2746/095777308x331548
Diagnostic ultrasound of the limb joints, muscle and bone in horses
Journal Article
Smith, M., & Smith, R. K. W. Diagnostic ultrasound of the limb joints, muscle and bone in horses. In Practice, 30(3), 152-159DIAGNOSTIC ultrasonography for the musculoskeletal system in the horse was first used in the early 1980s. Initial applications were directed towards the diagnosis of flexor tendon and ligament injuries in the distal limb, but this modality is now com... Read More about Diagnostic ultrasound of the limb joints, muscle and bone in horses.
Regenerative medicine for tendinous and ligamentous injuries of sport horses
Journal Article
Fortier, L. A., & Smith, R. K. W. Regenerative medicine for tendinous and ligamentous injuries of sport horses. https://doi.org/10.1016/j.cveq.2007.11.002After tendon injury the scar tissue that replaces the damaged tendon results in a substantial risk for reinjury. The goal of regenerative therapies is to restore normal structural architecture and biomechanical function to an injured tissue. Successf... Read More about Regenerative medicine for tendinous and ligamentous injuries of sport horses.
Skeletal physiology: responses to exercise and training
Book Chapter
Goodship, A. E., & Smith, R. K. W. Skeletal physiology: responses to exercise and training.
Can exercise modulate the maturation of functionally different immature tendons in the horse?
Journal Article
Kasashima, Y., Takahashi, T., Birch, H. L., Smith, R. K. W., & Goodship, A. E. Can exercise modulate the maturation of functionally different immature tendons in the horse?. Journal of Applied Physiology, 104(2), 416-422. https://doi.org/10.1152/japplphysiol.00379.2007Tendons can be considered in two functional groups, those contributing to energetics of locomotion and those acting solely to position the limb. The energy-storing tendons in both human and equine athletes have a high frequency of injury with similar... Read More about Can exercise modulate the maturation of functionally different immature tendons in the horse?.
The influence of exercise during growth on ultrasonographic parameters of the superficial digital flexor tendon of young Thoroughbred horses
Journal Article
Moffat, P. A., Firth, E. C., Rogers, C. W., Smith, R. K. W., Barneveld, A., Goodship, A. E., …Van Weeren, P. R. The influence of exercise during growth on ultrasonographic parameters of the superficial digital flexor tendon of young Thoroughbred horses. Equine Veterinary Journal, 40(2), 136-140. https://doi.org/10.2746/042516408x253109Reasons for performing study: Conditioning by early training may influence the composition of certain musculoskeletal tissues, but very few data exist on its effect during growth on tendon structure and function.
Evaluation of a new strategy to modulate skeletal development in Thoroughbred performance horses by imposing track-based exercise during growth
Journal Article
Rogers, C. W., Firth, E. C., McIlwraitht, C. W., Barneveld, A., Goodship, A. E., Kawcak, C. E., …Van Weeren, P. R. Evaluation of a new strategy to modulate skeletal development in Thoroughbred performance horses by imposing track-based exercise during growth. Equine Veterinary Journal, 40(2), 111-118. https://doi.org/10.2746/042516408x268923Reasons for performing study: No data exist on the intensity of exercise required or on possible harmful effects of increasing exercise in foals over the natural level when free at pasture.
Evaluation of a new strategy to modulate skeletal development in racehorses by imposing track-based exercise during growth: The effects on 2-and 3-year-old racing careers
Journal Article
Rogers, C. W., Firth, E. C., Mcilwraith, C. W., Barneveld, A., Goodship, A. E., Kawcak, C. E., …Van Weeren, P. R. Evaluation of a new strategy to modulate skeletal development in racehorses by imposing track-based exercise during growth: The effects on 2-and 3-year-old racing careers. Equine Veterinary Journal, 40(2), 119-127. https://doi.org/10.2746/042516408x266088Reasons for performing study: No data exist on the effects of conditioning exercise at foal age on workload and subsequent clinical injury rate during their 2- and 3-year-old racing careers.
Variants within the MMP3 gene are associated with Achilles tendinopathy: possible interaction with the COL5A1 gene
Journal Article
Raleigh, S. M., Van Der Merwe, L., Ribbans, W. J., Smith, R. K. W., Schwellnus, M. P., & Collins, M. Variants within the MMP3 gene are associated with Achilles tendinopathy: possible interaction with the COL5A1 gene. British Journal of Sports Medicine, 43(7), 514-520. https://doi.org/10.1136/bjsm.2008.053892
Gene expression markers of tendon fibroblasts in normal and diseased tissue compared to monolayer and three dimensional culture systems
Journal Article
Taylor, S. E., Vaughan-Thomas, A., Clements, D. N., Pinchbeck, G., Macrory, L. C., Smith, R. K. W., & Clegg, P. D. Gene expression markers of tendon fibroblasts in normal and diseased tissue compared to monolayer and three dimensional culture systems. BMC Musculoskeletal Disorders, 10(27), https://doi.org/10.1186/1471-2474-10-27
APPLICATION OF STRAIN TO CO-CULTURES OF EQUINE TENDON FIBROBLASTS AND MESENCHYMAL STROMAL CELLS DECREASES TENASCIN-C AND COLLAGEN TYPE-V EXPRESSION
Presentation / Conference Contribution
Taylor, S., Smith, R. K. W., & Clegg, P. APPLICATION OF STRAIN TO CO-CULTURES OF EQUINE TENDON FIBROBLASTS AND MESENCHYMAL STROMAL CELLS DECREASES TENASCIN-C AND COLLAGEN TYPE-V EXPRESSION. International Journal of Experimental Pathology, 90(1), A53-A54
Stem cells in veterinary medicine - attempts at regenerating equine tendon after injury
Journal Article
Richardson, L. E., Dudhia, J., Clegg, P. D., & Smith, R. K. W. Stem cells in veterinary medicine - attempts at regenerating equine tendon after injury. Trends in Biotechnology, 25(9), 409-416. https://doi.org/10.1016/j.tibtech.2007.07.009
A molecular marker of type I collagen metabolism reflects changes in connective tissue remodelling associated with injury to the equine superficial digital flexor tendon
Journal Article
Jackson, B. F., Smith, R. K. W., & Price, J. S. A molecular marker of type I collagen metabolism reflects changes in connective tissue remodelling associated with injury to the equine superficial digital flexor tendon. Equine Veterinary Journal, 35(2), 211-213. https://doi.org/10.2746/042516403776114135
The effects of local anaesthetic solution in the navicular bursa of horses with lameness caused by distal interphalangeal joint pain
Journal Article
Schumacher, J., Gillette, R., Degraves, F., Schramme, M., Smith, R. K. W., Perkins, J. D. M., & Coker, M. The effects of local anaesthetic solution in the navicular bursa of horses with lameness caused by distal interphalangeal joint pain. Equine Veterinary Journal, 35(5), 502-505
The distribution of cartilage oligomeric matrix protein (COMP) in equine carpal articular cartilage and its variation with exercise and cartilage deterioration
Journal Article
Murray, R. C., Smith, R. K. W., Henson, F. M. D., & Goodship, A. The distribution of cartilage oligomeric matrix protein (COMP) in equine carpal articular cartilage and its variation with exercise and cartilage deterioration
A comparison of the effects of two volumes of local analgesic solution in the distal interphalangeal joint of horses with lameness caused by solar toe or solar heel pain
Journal Article
Schumacher, J., de Graves, F., Steiger, R., Schramme, M., Smith, R. K. W., & Coker, M. A comparison of the effects of two volumes of local analgesic solution in the distal interphalangeal joint of horses with lameness caused by solar toe or solar heel pain. Equine Veterinary Journal, 33(3), 265-268. https://doi.org/10.2746/042516401776249778