All Outputs (4)

The use of small-bore wire-guided catheters for the management of peritoneal effusion in cats and dogs (2022)
Journal Article
Crosby, J., Humm, K., & Cook, S. (2022). The use of small-bore wire-guided catheters for the management of peritoneal effusion in cats and dogs. Journal of Veterinary Emergency and Critical Care, https://doi.org/10.1111/vec.13265

Objective – To describe the use of small-bore wire-guided catheters in the management of peritoneal effusion in cats and dogs and to detail any associated adverse events.
Design – Retrospective study.
Setting – University teaching hospital
Animals... Read More about The use of small-bore wire-guided catheters for the management of peritoneal effusion in cats and dogs.

Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor (2022)
Journal Article
Miller, D., Reuillon, T., Molyneux, L., Blackburn, T., Cook, S., Edwards, N., Endicott, J., Golding, B., Griffin, R., Hardcastle, I., Harnor, S., Heptinstall, A., Lochhead, P., Martin, M., Martin, N., Newell, D., Noble, R., Phillips, N., Rigoreau, L., Thomas, H., …Cano, C. (2022). Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor. Journal of Medicinal Chemistry, 65(9), 6513-6540. https://doi.org/10.1021/acs.jmedchem.1c01756

The nonclassical extracellular signal-related kinase 5 (ERK5) mitogen-activated protein kinase pathway has beenimplicated in increased cellular proliferation, migration, survival, and angiogenesis; hence, ERK5 inhibition may be an attractiveapproach... Read More about Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor.

Medical and surgical management of pancreatic fluid accumulations in dogs: a retrospective study of 15 cases (2022)
Journal Article
Talbot, C., Cheung, R., Holmes, E., & Cook, S. (2022). Medical and surgical management of pancreatic fluid accumulations in dogs: a retrospective study of 15 cases. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16411

Background – Limited data exist on the diagnosis and successful medical management of suspected pancreatic abscessation, and the appropriate terminology of this condition.
Hypothesis/Objectives – To describe the diagnosis and management of pancreat... Read More about Medical and surgical management of pancreatic fluid accumulations in dogs: a retrospective study of 15 cases.

Medically managed spontaneous bacterial peritonitis and bacteraemia associated with jugular catheter infection in a dog with tetanus (2022)
Journal Article
Radulescu, S., Le Gal, A., Guedra Allais, M., & cook, S. (2022). Medically managed spontaneous bacterial peritonitis and bacteraemia associated with jugular catheter infection in a dog with tetanus. Vet Record Case Reports, https://doi.org/10.1002/vrc2.354

A five-year-old male entire Labrador was treated for grade III tetanus, developing aspiration pneumonia and undergoing mechanical ventilation (MV). However, 5 days after weaning from MV the dog developed a new pyrexia. Investigations documented circu... Read More about Medically managed spontaneous bacterial peritonitis and bacteraemia associated with jugular catheter infection in a dog with tetanus.