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All Outputs (4)

Loss-of-function coding variants in the Ras of complex proteins/GTPase domain of leucine rich repeat kinase 2 (2025)
Journal Article
Butterfield, S., Herbst, S., & Lewis, P. (2025). Loss-of-function coding variants in the Ras of complex proteins/GTPase domain of leucine rich repeat kinase 2. Protein Science, 34(7), https://doi.org/10.1002/pro.70190

The LRRK2 gene is a key contributor to the genetic risk of Parkinson's disease, and a priority drug target for the disorder. Leucine Rich Repeat Kinase 2, the protein product of LRRK2, is a multidomain enzyme implicated in a range of cellular process... Read More about Loss-of-function coding variants in the Ras of complex proteins/GTPase domain of leucine rich repeat kinase 2.

Common genetic risk for Parkinson's disease and dysfunction of the endo-lysosomal system (2024)
Journal Article
Bhore, N., Bogacki, E., OCallaghan, B., Plun-Favreau, H., Lewis, P., & Herbst, S. (2024). Common genetic risk for Parkinson's disease and dysfunction of the endo-lysosomal system. Philosophical Transactions of the Royal Society B: Biological Sciences, 379(1899), https://doi.org/10.1098/rstb.2022.0517

Parkinson's disease is a progressive neurological disorder, characterized by prominent movement dysfunction. The past two decades have seen a rapid expansion of our understanding of the genetic basis of Parkinson's, initially through the identificati... Read More about Common genetic risk for Parkinson's disease and dysfunction of the endo-lysosomal system.