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All Outputs (176)

Effect of turnout rugs on the behaviour of horses under mild autumn conditions in the United Kingdom (2025)
Journal Article
Daw, F., Burn, C., Chang, Y.-M., & Nicol, C. (2025). Effect of turnout rugs on the behaviour of horses under mild autumn conditions in the United Kingdom. Applied Animal Behaviour Science, https://doi.org/10.1016/j.applanim.2025.106661

The use of rugs (blankets) for horses is commonplace as a protective measure to keep horses warm and dry in inclement weather, or to protect them from direct sunshine or insects under warmer conditions. However, rugs can also result in thermal or gen... Read More about Effect of turnout rugs on the behaviour of horses under mild autumn conditions in the United Kingdom.

Later-age neutering causes lower risk of early‐onset urinary incontinence than early neutering–a VetCompass target trial emulation study (2024)
Journal Article
O'Neill, D., Diaz-Ordaz, K., Pegram, C., Brodbelt, D. C., Chang, Y.-M., Hall, J. L., & Church, D. B. (2024). Later-age neutering causes lower risk of early‐onset urinary incontinence than early neutering–a VetCompass target trial emulation study. Herpetological Conservation and Biology, 19(7), e0305526. https://doi.org/10.1371/journal.pone.0305526

There is growing evidence supporting clinically important associations between age at neutering in bitches and subsequent urinary incontinence (UI), although much of this evidence to date is considered weak. Target trial emulation is an innovative ap... Read More about Later-age neutering causes lower risk of early‐onset urinary incontinence than early neutering–a VetCompass target trial emulation study.

Dietary magnesium supplementation in cats with chronic kidney disease: A prospective double-blind randomized controlled trial (2024)
Journal Article
Tang, P., van den Broek, D., Jepson, R., Geddes, R., Chang, Y., Loetter, N., Moniot, D., Biourge, V., & Elliott, J. (2024). Dietary magnesium supplementation in cats with chronic kidney disease: A prospective double-blind randomized controlled trial. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.17134

Background: Plasma total magnesium concentration (tMg) is a prognostic indicator in cats with chronic kidney disease (CKD), shorter survival time being associated with hypomagnesemia. Whether this risk factor is modifiable with dietary magnesium supp... Read More about Dietary magnesium supplementation in cats with chronic kidney disease: A prospective double-blind randomized controlled trial.

Large-scale statistical analysis of Mycobacterium tuberculosis genome sequences identifies compensatory mutations associated with multi-drug resistance (2024)
Journal Article
Billow, N., Phelan, J., Xia, D., Peng, Y., Clark, T. G., & Chang, Y.-M. (in press). Large-scale statistical analysis of Mycobacterium tuberculosis genome sequences identifies compensatory mutations associated with multi-drug resistance. Scientific Reports, https://doi.org/10.1038/s41598-024-62946-8

Tuberculosis (TB), caused by Mycobacterium tuberculosis, has a significant impact on global health worldwide. The development of multi-drug strains that are resistant to the first-line drugs isoniazid and rifampicin threatens public health security.... Read More about Large-scale statistical analysis of Mycobacterium tuberculosis genome sequences identifies compensatory mutations associated with multi-drug resistance.

ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats (2024)
Journal Article
LeVine, D., Kidd, L., Garden, O., Brooks, M., Goggs, R., Kohn, B., Mackin, A., Eldermire, E., Chang, Y., Allen, J., Christopherson, P., Glanemann, B., Maruyama, H., Naskou, M., Nielsen, L., Shropshire, S., Viall, A., Birkenheuer, A., Forman, M., Hanzlicek, A., …Spada, E. (2024). ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16996

Immune thrombocytopenia (ITP) is the most common acquired primary hemostatic disorder in dogs. Immune thrombocytopenia less commonly affects cats but is an important cause of mortality and treatment-associated morbidity in both species. Immune thromb... Read More about ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats.

An analysis of the welfare of fast-growing and slower-growing strains of broiler chicken (2024)
Journal Article
Nicol, C. J., Abeyesinghe, S. M., & Chang, Y.-M. (in press). An analysis of the welfare of fast-growing and slower-growing strains of broiler chicken. Frontiers in Animal Science, 5, https://doi.org/10.3389/fanim.2024.1374609

Due to concerns about the welfare of fast-growing (FG) strains of broiler chicken, animal welfare organisations have advocated the use of certain slower-growing (SG) strains that meet key welfare targets under test conditions. However, a widespread t... Read More about An analysis of the welfare of fast-growing and slower-growing strains of broiler chicken.

Target Trial Emulation: Does surgical versus non-surgical management of cranial cruciate ligament rupture in dogs cause different outcomes? (2024)
Journal Article
Pegram, C., Diaz-Ordaz, K., Brodbelt, D. C., Chang, Y.-M., von Hekkel, A. F., Wu, C.-H., Church, D. B., & O’Neill, D. G. (2024). Target Trial Emulation: Does surgical versus non-surgical management of cranial cruciate ligament rupture in dogs cause different outcomes?. Preventive Veterinary Medicine, 106165. https://doi.org/10.1016/j.prevetmed.2024.106165

Target trial emulation applies design principles from randomised controlled trials to the analysis of observational data for causal inference and is increasingly used within human epidemiology. Using anonymised veterinary clinical data from the VetCo... Read More about Target Trial Emulation: Does surgical versus non-surgical management of cranial cruciate ligament rupture in dogs cause different outcomes?.

Risk factors and implications associated with ultrasound-diagnosed nephrocalcinosis in cats with chronic kidney disease (2024)
Journal Article
Tang, P.-K., Geddes, R. F., Chang, Y.-M., Jepson, R. E., Van Den Broek, D. H. N., Lötter, N., & Elliott, J. (in press). Risk factors and implications associated with ultrasound-diagnosed nephrocalcinosis in cats with chronic kidney disease. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.17034

Background: Microscopic nephrocalcinosis is a common pathological feature of

Detection of nephrocalcinosis using ultrasonography, micro-computed tomography, and histopathology in cats (2024)
Journal Article
Tang, P., Geddes, R., Chang, Y., Jepson, R., van den Broek, D., Lötter, N., & Elliott, J. (2024). Detection of nephrocalcinosis using ultrasonography, micro-computed tomography, and histopathology in cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.17011

BackgroundIdentification of nephrocalcinosis in cats with chronic kidney disease (CKD) is of clinical interest but the ability of ultrasonography to detect nephrocalcinosis is uncertain.ObjectivesTo compare ultrasonography, micro-computed tomography... Read More about Detection of nephrocalcinosis using ultrasonography, micro-computed tomography, and histopathology in cats.

Effect of rabies booster vaccination on antibody levels in African wild dogs (Lycaon pictus) (2023)
Journal Article
Chang, Y.-M. (in press). Effect of rabies booster vaccination on antibody levels in African wild dogs (Lycaon pictus). Journal of Wildlife Diseases,

Rabies is a highly virulent viral disease that has been associated with large-scale population declines of the endangered African wild dog, Lycaon pictus. While rabies vaccination may be a valuable conservation tool in this species, studies indicate... Read More about Effect of rabies booster vaccination on antibody levels in African wild dogs (Lycaon pictus).

Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies (2023)
Journal Article
Knowles, E., Harris, P., Elliott, J., Chang, Y., & Menzies-Gow, N. (2023). Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.13983

Background: Serum insulin concentration at 60 min (InsulinT60) during an oral sugar test (OST) indicates future laminitis risk and insulin dysregulation (ID). Associations between InsulinT60 and physical and owner-reported variables may help clinicia... Read More about Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies.

Feature Weighted Models (FWM) to address lineage dependency in drug-resistance prediction from Mycobacterium tuberculosis genome sequences (2023)
Journal Article
Chang, Y.-M., Xia, D., & Billows, N. (2023). Feature Weighted Models (FWM) to address lineage dependency in drug-resistance prediction from Mycobacterium tuberculosis genome sequences. Bioinformatics, 39(7), https://doi.org/10.1093/bioinformatics/btad428

Background: Tuberculosis is caused by members of the Mycobacterium tuberculosis complex (MTBC) and is the second leading infectious killer after COVID-19. The evolution of drug-resistance poses a threat to successful treatment and disease eradication... Read More about Feature Weighted Models (FWM) to address lineage dependency in drug-resistance prediction from Mycobacterium tuberculosis genome sequences.

Effect of a specially formulated diet on progression of heart enlargement in dogs with subclinical degenerative mitral valve disease (2023)
Journal Article
Oyama, M., Scansen, B., Boswood, A., Goldfeder, G., Rosenthal, S., Cober, R., LaFauci, K., Friese, R., Gomes, M., Chang, Y., & Li, Q. (2023). Effect of a specially formulated diet on progression of heart enlargement in dogs with subclinical degenerative mitral valve disease. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16796

BackgroundPrevious studies in dogs with degenerative mitral valve disease (DMVD) have identified altered myocardial energy metabolism and oxidation, which might contribute to cardiac hypertrophy. Diets rich in medium chain fatty acids and antioxidant... Read More about Effect of a specially formulated diet on progression of heart enlargement in dogs with subclinical degenerative mitral valve disease.

Effects of external ambient temperature at loading, journey duration and flock characteristics on the dead-on-arrival rate in broiler chickens transported to slaughter in Great Britain (2023)
Journal Article
Allen, S., Parker, C., Verheyen, K., Nicol, C., & Chang, Y. (2023). Effects of external ambient temperature at loading, journey duration and flock characteristics on the dead-on-arrival rate in broiler chickens transported to slaughter in Great Britain. Poultry Science, 102(6), https://doi.org/10.1016/j.psj.2023.102634

Broiler mortality during transport and lairage, prior to slaughter, has negative welfare and eco-nomic implications. Knowledge of the factors affecting the dead-on-arrival (DOA) rate can help identify risk-mitigating strategies. The objectives of thi... Read More about Effects of external ambient temperature at loading, journey duration and flock characteristics on the dead-on-arrival rate in broiler chickens transported to slaughter in Great Britain.

Effects of ambient temperature, journey duration and flock characteristics on the dead-on-arrival rate in British broiler chickens transported to slaughter (2023)
Journal Article
Chang, Y.-M., Verheyen, K., Nicol, C., & Allen, S. (2023). Effects of ambient temperature, journey duration and flock characteristics on the dead-on-arrival rate in British broiler chickens transported to slaughter. Poultry Science, https://doi.org/10.1016/j.psj.2023.102634

Broiler mortality during transport and lairage, prior to slaughter, has negative welfare and economic implications. Knowledge of the factors affecting the dead-on-arrival (DOA) rate can help identify risk-mitigating strategies. The objectives of this... Read More about Effects of ambient temperature, journey duration and flock characteristics on the dead-on-arrival rate in British broiler chickens transported to slaughter.

Individual Monitoring of Activity and Lameness in Conventional and Slower-Growing Breeds of Broiler Chickens Using Accelerometers (2023)
Journal Article
Pearce, J., Chang, Y.-M. R., & Abeyesinghe, S. (2023). Individual Monitoring of Activity and Lameness in Conventional and Slower-Growing Breeds of Broiler Chickens Using Accelerometers. Animals, 13(9), 1432. https://doi.org/10.3390/ani13091432

Accelerometers are increasingly being investigated to detect animal behaviour as a method for monitoring individual welfare that overcomes manual challenges associated with time, re-source, and discrete sampling. We investigated the effects of broile... Read More about Individual Monitoring of Activity and Lameness in Conventional and Slower-Growing Breeds of Broiler Chickens Using Accelerometers.

Regional modular responses in different bone compartments to the anabolic effect of PTH (1-34) and axial loading in mice (2023)
Journal Article
Monzem, S., Valkani, D., Evans, L., Chang, Y., & Pitsillides, A. (2023). Regional modular responses in different bone compartments to the anabolic effect of PTH (1-34) and axial loading in mice. BONE, 170, https://doi.org/10.1016/j.bone.2023.116720

Beneficial effects of intermittent parathyroid hormone (PTH) on bone mass and architecture are described to either simply add to, or to synergise with those of mechanical loading. We evaluate whether interaction with in vivo loading is reinforced by... Read More about Regional modular responses in different bone compartments to the anabolic effect of PTH (1-34) and axial loading in mice.

Risk factors for unilateral cranial cruciate ligament rupture diagnosis and for clinical management in dogs under primary veterinary care in the UK (2023)
Journal Article
Pegram, C., Brodbelt, D., Diaz-Ordaz, K., Chang, Y.-M., Frykfors von Hekkel, A., Church, D., & O'Neill, D. (2023). Risk factors for unilateral cranial cruciate ligament rupture diagnosis and for clinical management in dogs under primary veterinary care in the UK. The Veterinary Journal, https://doi.org/10.1016/j.tvjl.2023.105952

This study aimed to evaluate demographic risk factors associated with unilateral cranial cruciate ligament (CCL) rupture diagnosis and to explore demographic and clinical risk factors associated with management of unilateral CCL rupture in dogs under... Read More about Risk factors for unilateral cranial cruciate ligament rupture diagnosis and for clinical management in dogs under primary veterinary care in the UK.

Exploring the role of immune checkpoint inhibitors in the etiology of myasthenia gravis and Lambert-Eaton myasthenic syndrome: A systematic review (2023)
Journal Article
Seligman, C., Chang, Y., Luo, J., & Garden, O. (2023). Exploring the role of immune checkpoint inhibitors in the etiology of myasthenia gravis and Lambert-Eaton myasthenic syndrome: A systematic review. Frontiers in Neurology, 13, https://doi.org/10.3389/fneur.2022.1004810

Background While immune checkpoint inhibitors (ICIs) have been revolutionary in the treatment of cancer, their administration has been associated with a variety of immune-related adverse events (irAEs), including myasthenia gravis (MG), and Lambert-E... Read More about Exploring the role of immune checkpoint inhibitors in the etiology of myasthenia gravis and Lambert-Eaton myasthenic syndrome: A systematic review.