Skip to main content

Research Repository

Advanced Search

Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies (2023)
Journal Article
Knowles, E., Harris, P., Elliott, J., Chang, Y., & Menzies-Gow, N. (2023). Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.13983

Background: Serum insulin concentration at 60 min (InsulinT60) during an oral sugar test (OST) indicates future laminitis risk and insulin dysregulation (ID). Associations between InsulinT60 and physical and owner-reported variables may help clinicia... Read More about Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies.

Feature Weighted Models (FWM) to address lineage dependency in drug-resistance prediction from Mycobacterium tuberculosis genome sequences (2023)
Journal Article
Chang, Y., Xia, D., & Billows, N. (2023). Feature Weighted Models (FWM) to address lineage dependency in drug-resistance prediction from Mycobacterium tuberculosis genome sequences. Bioinformatics, 39(7), https://doi.org/10.1093/bioinformatics/btad428

Background: Tuberculosis is caused by members of the Mycobacterium tuberculosis complex (MTBC) and is the second leading infectious killer after COVID-19. The evolution of drug-resistance poses a threat to successful treatment and disease eradication... Read More about Feature Weighted Models (FWM) to address lineage dependency in drug-resistance prediction from Mycobacterium tuberculosis genome sequences.

Effects of external ambient temperature at loading, journey duration and flock characteristics on the dead-on-arrival rate in broiler chickens transported to slaughter in Great Britain (2023)
Journal Article
Allen, S., Parker, C., Verheyen, K., Nicol, C., & Chang, Y. (2023). Effects of external ambient temperature at loading, journey duration and flock characteristics on the dead-on-arrival rate in broiler chickens transported to slaughter in Great Britain. Poultry Science, 102(6), https://doi.org/10.1016/j.psj.2023.102634

Broiler mortality during transport and lairage, prior to slaughter, has negative welfare and eco-nomic implications. Knowledge of the factors affecting the dead-on-arrival (DOA) rate can help identify risk-mitigating strategies. The objectives of thi... Read More about Effects of external ambient temperature at loading, journey duration and flock characteristics on the dead-on-arrival rate in broiler chickens transported to slaughter in Great Britain.

Effects of ambient temperature, journey duration and flock characteristics on the dead-on-arrival rate in British broiler chickens transported to slaughter (2023)
Journal Article
Chang, Y., Verheyen, K., Nicol, C., & Allen, S. (2023). Effects of ambient temperature, journey duration and flock characteristics on the dead-on-arrival rate in British broiler chickens transported to slaughter. Poultry Science, https://doi.org/10.1016/j.psj.2023.102634

Broiler mortality during transport and lairage, prior to slaughter, has negative welfare and economic implications. Knowledge of the factors affecting the dead-on-arrival (DOA) rate can help identify risk-mitigating strategies. The objectives of this... Read More about Effects of ambient temperature, journey duration and flock characteristics on the dead-on-arrival rate in British broiler chickens transported to slaughter.

Individual Monitoring of Activity and Lameness in Conventional and Slower-Growing Breeds of Broiler Chickens Using Accelerometers (2023)
Journal Article
Pearce, J., Chang, Y. R., & Abeyesinghe, S. (2023). Individual Monitoring of Activity and Lameness in Conventional and Slower-Growing Breeds of Broiler Chickens Using Accelerometers. Animals, 13(9), 1432. https://doi.org/10.3390/ani13091432

Accelerometers are increasingly being investigated to detect animal behaviour as a method for monitoring individual welfare that overcomes manual challenges associated with time, re-source, and discrete sampling. We investigated the effects of broile... Read More about Individual Monitoring of Activity and Lameness in Conventional and Slower-Growing Breeds of Broiler Chickens Using Accelerometers.

Regional modular responses in different bone compartments to the anabolic effect of PTH (1-34) and axial loading in mice (2023)
Journal Article
Monzem, S., Valkani, D., Evans, L., Chang, Y., & Pitsillides, A. (2023). Regional modular responses in different bone compartments to the anabolic effect of PTH (1-34) and axial loading in mice. BONE, 170, https://doi.org/10.1016/j.bone.2023.116720

Beneficial effects of intermittent parathyroid hormone (PTH) on bone mass and architecture are described to either simply add to, or to synergise with those of mechanical loading. We evaluate whether interaction with in vivo loading is reinforced by... Read More about Regional modular responses in different bone compartments to the anabolic effect of PTH (1-34) and axial loading in mice.

Risk factors for unilateral cranial cruciate ligament rupture diagnosis and for clinical management in dogs under primary veterinary care in the UK (2023)
Journal Article
Pegram, C., Brodbelt, D., Diaz-Ordaz, K., Chang, Y., Frykfors von Hekkel, A., Church, D., & O'Neill, D. (2023). Risk factors for unilateral cranial cruciate ligament rupture diagnosis and for clinical management in dogs under primary veterinary care in the UK. The Veterinary Journal, https://doi.org/10.1016/j.tvjl.2023.105952

This study aimed to evaluate demographic risk factors associated with unilateral cranial cruciate ligament (CCL) rupture diagnosis and to explore demographic and clinical risk factors associated with management of unilateral CCL rupture in dogs under... Read More about Risk factors for unilateral cranial cruciate ligament rupture diagnosis and for clinical management in dogs under primary veterinary care in the UK.

Exploring the role of immune checkpoint inhibitors in the etiology of myasthenia gravis and Lambert-Eaton myasthenic syndrome: A systematic review (2023)
Journal Article
Seligman, C., Chang, Y., Luo, J., & Garden, O. (2023). Exploring the role of immune checkpoint inhibitors in the etiology of myasthenia gravis and Lambert-Eaton myasthenic syndrome: A systematic review. Frontiers in Neurology, 13, https://doi.org/10.3389/fneur.2022.1004810

Background While immune checkpoint inhibitors (ICIs) have been revolutionary in the treatment of cancer, their administration has been associated with a variety of immune-related adverse events (irAEs), including myasthenia gravis (MG), and Lambert-E... Read More about Exploring the role of immune checkpoint inhibitors in the etiology of myasthenia gravis and Lambert-Eaton myasthenic syndrome: A systematic review.

Economic evaluation of antimicrobial usage surveillance in livestock: -EN- Economic evaluation of antimicrobial usage surveillance in livestock -FR- Évaluation économique de la surveillance exercée sur l'utilisation d'agents antimicrobiens chez les animaux d'élevage -ES- Evaluación en clave económica de la vigilancia del uso de agentes antimicrobianos en el ganado (2023)
Journal Article
ALARCON, P., STRANG, C., CHANG, Y., & TAK, M. (2023). Economic evaluation of antimicrobial usage surveillance in livestock: -EN- Economic evaluation of antimicrobial usage surveillance in livestock -FR- Évaluation économique de la surveillance exercée sur l'utilisation d'agents antimicrobiens chez les animaux d'élevage -ES- Evaluación en clave económica de la vigilancia del uso de agentes antimicrobianos en el ganado. Scientific and Technical Review, 42, 42-51. https://doi.org/10.20506/rst.42.3347

Investigation of in vitro susceptibility and resistance mechanisms in skin pathogens: perspectives for fluoroquinolone therapy in canine pyoderma (2022)
Journal Article
Azzariti, S., Bond, R., Loeffler, A., Zendri, F., Timofte, D., Chang, Y., & Pelligand, L. (2022). Investigation of in vitro susceptibility and resistance mechanisms in skin pathogens: perspectives for fluoroquinolone therapy in canine pyoderma. Antibiotics, https://doi.org/10.3390/antibiotics11091204

Fluoroquinolones (FQ) are commonly used in dogs with bacterial skin infections. Their use as first choice, along with the increased incidence of FQ-resistance, represents a risk to animal and public health. Our study determined minimum inhibitory (M... Read More about Investigation of in vitro susceptibility and resistance mechanisms in skin pathogens: perspectives for fluoroquinolone therapy in canine pyoderma.

Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies. (2022)
Journal Article
Finding, E., Elliott, J., Harris, P., & Menzies-Gow, N. (2022). Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies. Research in Veterinary Science, https://doi.org/10.1016/j.rvsc.2022.05.012

Previously laminitic (PL) ponies are reported to have higher blood pressure than non laminitic (NL) ponies. This relative hypertension may be related to endothelial cell dysfunction, similar to humans with metabolic syndrome. To investigate the relat... Read More about Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies..

The importance of fine-scale predictors of wild boar habitat use in an isolated population (2022)
Journal Article
Bacigalupo, S. A., Chang, Y., Dixon, L. K., Gubbins, S., & Drewe, J. A. (2022). The importance of fine-scale predictors of wild boar habitat use in an isolated population. Ecology and Evolution, 12, -. https://doi.org/10.1002/ece3.9031

1. Predicting the likelihood of wildlife presence at potential wildlife-livestock interfaces is challenging. These interfaces are usually relatively small geographical areas where landscapes show large variation over small distances. Models of wildli... Read More about The importance of fine-scale predictors of wild boar habitat use in an isolated population.

The importance of fine-scale predictors of wild boar presence in an isolated population (2022)
Journal Article
Bacigalupo, S. A., Chang, Y., Dixon, L. K., Gubbins, S., Kucharski, A. J., & Drewe, J. A. (2022). The importance of fine-scale predictors of wild boar presence in an isolated population. Methods in Ecology and Evolution, https://doi.org/10.1002/ece3.9031

1. Predicting the likelihood of wildlife presence at potential wildlife-livestock interfaces is challenging. These interfaces are usually relatively small geographical areas where landscapes show large variation over small distances. Models of wildli... Read More about The importance of fine-scale predictors of wild boar presence in an isolated population.

Prospective evaluation of novel biomarkers of acute kidney injury in dogs following cardiac surgery under cardiopulmonary bypass (2022)
Journal Article
Starybrat, D., Jepson, R., Bristow, P., Peterson, S., Yerramilli, M., Yerramilli, M., …Cortellini, S. (in press). Prospective evaluation of novel biomarkers of acute kidney injury in dogs following cardiac surgery under cardiopulmonary bypass. Journal of Veterinary Emergency and Critical Care,

Objective - Assess the occurrence of acute kidney injury (AKI) in dogs undergoing cardiac surgery under cardiopulmonary bypass (CPB) and explore associations between traditional and novel serum and urinary biomarkers. Design – Prospective cohort st... Read More about Prospective evaluation of novel biomarkers of acute kidney injury in dogs following cardiac surgery under cardiopulmonary bypass.

Machine learning classification methods informing the management of inconclusive reactors at bovine tuberculosis surveillance tests in England (2021)
Journal Article
Romero, M. P., Chang, Y., Brunton, L. A., Parry, J., Prosser, A., Upton, P., & Drewe, J. A. (2021). Machine learning classification methods informing the management of inconclusive reactors at bovine tuberculosis surveillance tests in England. Preventive Veterinary Medicine,

Bovine tuberculosis (bTB) remains one of the most complex, challenging, and costly animal health problems in England. Identifying and promptly removing all infected cattle from affected herds is key to its eradication strategy; the imperfect sensitiv... Read More about Machine learning classification methods informing the management of inconclusive reactors at bovine tuberculosis surveillance tests in England.

Predictors of laminitis development in a cohort of non-laminitic ponies (2021)
Journal Article
Knowles, E., Elliott, J., Harris, P., Chang, R., & Menzies-Gow, N. (2021). Predictors of laminitis development in a cohort of non-laminitic ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.31_13492

Background: Quantifying the risk of laminitis development requires improvement. Objectives: To identify the most useful physical examination, metabolic and management factors to predict future laminitis development in client-owned, non-laminitic pon... Read More about Predictors of laminitis development in a cohort of non-laminitic ponies.

Bite Wound Management In Ring-Tailed Lemurs: A Retrospective Study Of Bite Wound Management In Ring-Tailed Lemurs (Lemur Catta) Housed Within Five British Zoos. (2021)
Journal Article
Ceccolini, M., Hedley, J., Chang, Y., & Guthrie, A. (in press). Bite Wound Management In Ring-Tailed Lemurs: A Retrospective Study Of Bite Wound Management In Ring-Tailed Lemurs (Lemur Catta) Housed Within Five British Zoos. Journal of Zoo and Wildlife Medicine,

Captive nonhuman primates frequently experience bite wounds inflicted by conspecifics; however, few studies evaluate wound management in these animals. This study evaluates bite wound management in 35 captive ring-tailed lemurs (RTL, Lemur catta) hel... Read More about Bite Wound Management In Ring-Tailed Lemurs: A Retrospective Study Of Bite Wound Management In Ring-Tailed Lemurs (Lemur Catta) Housed Within Five British Zoos..

Associations between behaviour and health outcomes in conventional and slow-growing breeds of broiler chicken (2021)
Journal Article
Abeyesinghe, S., Abeyesinghe, S., Chancellor, N., Hernandez Moore, D., Chang, Y., Pearce, J., …Nicol, C. (2021). Associations between behaviour and health outcomes in conventional and slow-growing breeds of broiler chicken. animal, 15(7), https://doi.org/10.1016/j.animal.2021.100261

Broiler chickens are prone to a range of complex health and welfare issues. To support informed selection of welfare traits whilst minimising impact on production efficiency and to address a major gap in understanding, we systematically explored asso... Read More about Associations between behaviour and health outcomes in conventional and slow-growing breeds of broiler chicken.

Changes in retinal vascular diameters in senior and geriatric cats in association with variation in systemic blood pressure (2021)
Journal Article
Enache, A., Dietrich, U., Drury, O., Trucco, E., MacGillivray, T., Syme, H., …Chang, Y. (2021). Changes in retinal vascular diameters in senior and geriatric cats in association with variation in systemic blood pressure. Journal of Feline Medicine and Surgery,

Objectives Early diagnosis of arterial hypertension is essential to prevent target organ damage. In humans, retinal arteriolar narrowing predicts hypertension. This blinded prospective observational study investigated the retinal vessel diameters amo... Read More about Changes in retinal vascular diameters in senior and geriatric cats in association with variation in systemic blood pressure.

Systematic analysis reveals that colony housing aligns gait profiles and strengthens link between 1 histological and micro-CT bone markers in rat models of osteoarthritis 2 Short running title: Colony housing strengthens osteoarthritis research (2021)
Journal Article
Chang, Y., Menges, S., Westhof, A., Kleinschmidt-Doerr, K., Brenneis, C., Pitsillides, A. A., & Chang, Y. (in press). Systematic analysis reveals that colony housing aligns gait profiles and strengthens link between 1 histological and micro-CT bone markers in rat models of osteoarthritis 2 Short running title: Colony housing strengthens osteoarthritis research. FASEB Journal, -. https://doi.org/10.1096/fj.202002009R