LOSS OF FUNCTION ALPHA10BETA1 MICE EXHIBIT REDUCED BONE VOLUME
Presentation / Conference Contribution
Collinson, R. S., Bengtsson, T., Lundgren-Akerlund, E., & Pitsillides, A. A. LOSS OF FUNCTION ALPHA10BETA1 MICE EXHIBIT REDUCED BONE VOLUME
All Outputs (167)
A critical evaluation of specific aspects of joint development
Journal Article
Pitsillides, A. A., & Ashhurst, D. E. A critical evaluation of specific aspects of joint development. Developmental Dynamics, 237(9), 2284-2294. https://doi.org/10.1002/dvdy.21654Synovial joint formation has been divided into two phases; the formation of the anlagen of the opposing bones and the interzone and the later formation of the joint cavity. Here we review current theories on the mechanism by which these events are ac... Read More about A critical evaluation of specific aspects of joint development.
IN VIVO LOADING OF MURINE KNEE JOINTS: VALIDATION AS A MODEL FOR THE STUDY OF OA
Presentation / Conference Contribution
Poulet, B., Collinson, R., & Pitsillides, A. A. IN VIVO LOADING OF MURINE KNEE JOINTS: VALIDATION AS A MODEL FOR THE STUDY OF OA
E11 AND RHOA SIGNALLING DURING OSTEOCYTOGENESIS
Presentation / Conference Contribution
Prideaux, M., Pitsillides, A. A., Loveridge, N., & Farquharson, C. E11 AND RHOA SIGNALLING DURING OSTEOCYTOGENESIS
A NOVEL PROFILE ANALYSIS OF METAPHYSEAL TRABECULAR BONE REVEALS A BIPHASIC DOSE-DEPENDENT RESPONSE TO ADMINISTERED BONE ACTIVE AGENTS
Journal Article
Salmon, P., Pitsillides, A. A., Tivesten, A., Moverare-Skrtic, S., Ohlsson, C., Oste, L., Dixon, G., Idris, A., & Van T'Hof, R. A NOVEL PROFILE ANALYSIS OF METAPHYSEAL TRABECULAR BONE REVEALS A BIPHASIC DOSE-DEPENDENT RESPONSE TO ADMINISTERED BONE ACTIVE AGENTS
Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis
Journal Article
Staines, K. A., Ikpegbu, E., Tornqvist, A. E., Dillon, S., Javaheri, B., Amin, A. K., Clements, D. N., Buttle, D. J., Pitsillides, A. A., & Farquharson, C. (in press). Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis. BMC Musculoskeletal Disorders, 20, https://doi.org/10.1186/s12891-019-2731-9Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, we examine whether disruption to the SCB o... Read More about Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis.
The in vitro behaviour of canine osteoblasts derived from different bone types
Journal Article
Meeson, R. L., Perpétuo, I. P., Parsons, K. J., Orriss, I. R., Shah, M., Pitsillides, A. A., & Doube, M. (in press). The in vitro behaviour of canine osteoblasts derived from different bone types. BMC Veterinary Research, 15(114), https://doi.org/10.1186/s12917-019-1857-1
MURINE CRUCIATE LIGAMENT DEGENERATION AND MARKER EXPRESSION DURING OSTEOARTHRITIS
Presentation / Conference Contribution
Ramos, L. D., Bou-Gharios, G., Pitsillides, A. A., Comerford, E. J., & Poulet, B. MURINE CRUCIATE LIGAMENT DEGENERATION AND MARKER EXPRESSION DURING OSTEOARTHRITIS
Deficiency and Also Transgenic Overexpression of Timp-3 Both Lead to Compromised Bone Mass and Architecture In Vivo
Journal Article
Javaheri, B., Hopkinson, M., Poulet, B., Pollard, A. S., Shefelbine, S. J., Chang, Y. M., Francis-West, P., Bou-Gharios, G., & Pitsillides, A. A. (in press). Deficiency and Also Transgenic Overexpression of Timp-3 Both Lead to Compromised Bone Mass and Architecture In Vivo. PLoS ONE, 11(8), e0159657. https://doi.org/10.1371/journal.pone.0159657
The anabolic action of intermittent parathyroid hormone on cortical bone depends partly on its ability to induce nitric oxide-mediated vasorelaxation in BALB/c mice
Journal Article
Gohin, S., Carriero, A., Chenu, C., Pitsillides, A. A., Arnett, T. R., & Marenzana, M. (in press). The anabolic action of intermittent parathyroid hormone on cortical bone depends partly on its ability to induce nitric oxide-mediated vasorelaxation in BALB/c mice. Cell Biochemistry and Function, 34(2), 52-62. https://doi.org/10.1002/cbf.3164
SPONTANEOUS HOME CAGE ACTIVITY IS SENSITIVE TO ANTI-NGF TREATMENT OR CAN BE LINKED TO JOINT STIFFNESS IN DIFFERENT MODELS OF SURGERY-INDUCED OSTEOARTHRITIS
Journal Article
Brenneis, C., Westhof, A., Duschek, J., Chang, Y. M., Pitsillides, A. A., Michaelis, M., Kleinschmidt, K., & Guehring, H. SPONTANEOUS HOME CAGE ACTIVITY IS SENSITIVE TO ANTI-NGF TREATMENT OR CAN BE LINKED TO JOINT STIFFNESS IN DIFFERENT MODELS OF SURGERY-INDUCED OSTEOARTHRITIS
PENALIZED LINEAR DISCRIMINANT ANALYSIS REVEALS DIVERGENT GAIT PATTERNS IN THREE SURGICALLY-INDUCED OA MODELS
Journal Article
Chang, Y. M., Marsh-Dougerthy, J., Brenneis, C., Kleinschmidt, K., Michaelis, M., Guehring, H., Piles, M., & Pitsillides, A. A. PENALIZED LINEAR DISCRIMINANT ANALYSIS REVEALS DIVERGENT GAIT PATTERNS IN THREE SURGICALLY-INDUCED OA MODELS
Non-Invasive Mouse Models of Post-Traumatic Osteoarthritis
Journal Article
Christiansen, B. A., Guilak, F., Lockwood, K. A., Olson, S. A., Pitsillides, A. A., Sandell, L. J., Silva, M. J., Van Der Meulen, M. C. H., & Haudenschild, D. R. (in press). Non-Invasive Mouse Models of Post-Traumatic Osteoarthritis. Osteoarthritis and Cartilage, 23(10), 1627-1638. https://doi.org/10.1016/j.joca.2015.05.009
MMP and TIMP temporal gene expression during osteocytogenesis
Journal Article
Prideaux, M., Staines, K. A., Jones, E. R., Riley, G. P., Pitsillides, A. A., & Farquharson, C. (in press). MMP and TIMP temporal gene expression during osteocytogenesis. Gene Expression Patterns, 18(1-2), 29-36. https://doi.org/10.1016/j.gep.2015.04.004Osteocytes within bone differentiate from osteoblast precursors which reside in a mineralised extracellular matrix (ECM). Fully differentiated osteocytes are critical for bone development and function but the factors that regulate this differentiatio... Read More about MMP and TIMP temporal gene expression during osteocytogenesis.
A HOLE IN THE HEAD; DEVELOPMENT OF CRANIAL FORAMINA IN THE CHICK EMBRYO
Presentation / Conference Contribution
Akbareian, S. E., Fowkes, R. C., Macharia, R., Pitsillides, A. A., & McGonnell, I. M. A HOLE IN THE HEAD; DEVELOPMENT OF CRANIAL FORAMINA IN THE CHICK EMBRYO
TRABECULAR ADAPTIVE RESPONSE TO LOADING IN AGED MICE IS RESTORED BY PRE-EXPOSURE TO SUPRAPHYSIOLOGICAL LOADS
Presentation / Conference Contribution
Javaheri, B., Wood, M. J., Carriero, A., Shefelbine, S., & Pitsillides, A. A. TRABECULAR ADAPTIVE RESPONSE TO LOADING IN AGED MICE IS RESTORED BY PRE-EXPOSURE TO SUPRAPHYSIOLOGICAL LOADS
GENDER DIFFERENCES OA PROGRESSION AND THEIR LONGITUDINAL GAIT CHANGES
Journal Article
Piles, M., De Souza, R., Poulet, B., Pitsillides, A. A., & Chang, Y. M. GENDER DIFFERENCES OA PROGRESSION AND THEIR LONGITUDINAL GAIT CHANGES
IDENTIFYING MECHANISMS AND EVOLUTIONARY IMPLICATIONS OF MECHANOSENSITIVE GROWTH IN THE EMBRYONIC LIMB SKELETON
Presentation / Conference Contribution
Pollard, A. S., Charlton, B. G., McGonnell, I. M., & Pitsillides, A. A. IDENTIFYING MECHANISMS AND EVOLUTIONARY IMPLICATIONS OF MECHANOSENSITIVE GROWTH IN THE EMBRYONIC LIMB SKELETON
MECHANOSENSITIVITY OF EMBRYONIC LIMBS: MECHANO-SENSITIVE AND INSENSITIVE PERIODS OF GROWTH, DIFFERENTIAL SENSITIVITY BETWEEN LIMB ELEMENTS, AND THE UNDERPINNING MECHANISMS
Presentation / Conference Contribution
Pollard, A. S., McGonnell, I. M., Chenu, C., Farquharson, C., & Pitsillides, A. A. MECHANOSENSITIVITY OF EMBRYONIC LIMBS: MECHANO-SENSITIVE AND INSENSITIVE PERIODS OF GROWTH, DIFFERENTIAL SENSITIVITY BETWEEN LIMB ELEMENTS, AND THE UNDERPINNING MECHANISMS
SYSTEMATIZING MURINE MENISCAL AND LIGAMENT MODIFICATIONS DURING OSTEOARTHRITIS
Journal Article
Poulet, B., Bou-Gharios, G., & Pitsillides, A. A. SYSTEMATIZING MURINE MENISCAL AND LIGAMENT MODIFICATIONS DURING OSTEOARTHRITIS