Limb proportions show developmental plasticity in response to embryo movement

Pollard, A S; Charlton, B G; Hutchinson, J R; Gustafsson, T; McGonnell, I M; Timmons, J A; Pitsillides, A A

doi:10.1038/srep41926

All Outputs (6)

Distinct cerebellar foliation anomalies in a Chd7 haploinsufficient mouse model of CHARGE syndrome (2017)
Journal Article
Whittaker, D. E., Kasah, S., Donovan, A. P. A., Ellegood, J., Riegman, K. L. H., Volk, H. A., McGonnell, I. M., Lerch, J. P., & Basson, A. (2017). Distinct cerebellar foliation anomalies in a Chd7 haploinsufficient mouse model of CHARGE syndrome. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 175(4), 465-477. https://doi.org/10.1002/ajmg.c.31595

Mutations in the gene encoding the ATP dependent chromatin‐remodeling factor, CHD7 are the major cause of CHARGE (Coloboma, Heart defects, Atresia of the choanae, Retarded growth and development, Genital‐urinary anomalies, and Ear defects) syndrome.... Read More about Distinct cerebellar foliation anomalies in a Chd7 haploinsufficient mouse model of CHARGE syndrome.

Cavalier King Charles Spaniels with Chiari-like malformation and Syringomyelia have increased variability of spatio-temporal gait characteristics (2017)
Journal Article
Olsen, E., Suiter, E. J., Pfau, T., McGonnell, I. M., Matiasek, K., Giejda, A., & Volk, H. A. (2017). Cavalier King Charles Spaniels with Chiari-like malformation and Syringomyelia have increased variability of spatio-temporal gait characteristics. BMC Veterinary Research, 13(159), https://doi.org/10.1186/s12917-017-1077-5

Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes (2017)
Journal Article
Jonas, K. C., Melrose, T., Thompson, I. R., Baxter, G. F., Lipscomb, V. J., Niessen, S. J. M., Lawson, C., McArdle, C. A., Roberson, M. S., McGonnell, I. M., Wheeler-Jones, C. P. D., & Fowkes, R. C. (2017). Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes. Cell and Tissue Research, 369(3), 567-578. https://doi.org/10.1007/s00441-017-2624-x

The natriuretic peptides, Atrial-, B-type and C-type natriuretric peptides (ANP, BNP, CNP), are regulators of many endocrine tissues and exert their effects predominantly through the activation of their specific guanylyl cyclase receptors (GC-A and G... Read More about Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes.

The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression (2017)
Journal Article
Whittaker, D. E., Riegman, K. L. H., Kasah, S., Mohan, C., Yu, T., Sala, B. P., Hebaishi, H., Caruso, A., Marques, A. C., Michetti, C., Smachetti, M. E. S., Shah, A., Sabbioni, M., Kulhanci, O., Tee, W.-W., Reinberg, D., Scattoni, M. L., Volk, H. A., McGonnell, I. M., Wardle, F. C., …Basson, M. A. (2017). The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression. Journal of Clinical Investigation, 127(3), 874-887. https://doi.org/10.1172/JCI83408

The mechanisms underlying the neurodevelopmental deficits associated with CHARGE syndrome, which include cerebellar hypoplasia, developmental delay, coordination problems, and autistic features, have not been identified. CHARGE syndrome has been asso... Read More about The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression.

The role of embryo movement in the development of the furcula (2017)
Journal Article
Pollard, A. S., Boyd, S., McGonnell, I. M., & Pitsillides, A. A. (2017). The role of embryo movement in the development of the furcula. Journal of Anatomy, 230(3), 435-443. https://doi.org/10.1111/joa.12571

The pectoral girdle is a complex structure which varies in its morphology between species. A major component in birds is the furcula, which can be considered equivalent to a fusion of the paired clavicles found in many mammals, and the single intercl... Read More about The role of embryo movement in the development of the furcula.

Limb proportions show developmental plasticity in response to embryo movement (2017)
Journal Article
Pollard, A. S., Charlton, B. G., Hutchinson, J. R., Gustafsson, T., McGonnell, I. M., Timmons, J. A., & Pitsillides, A. A. (2017). Limb proportions show developmental plasticity in response to embryo movement. https://doi.org/10.1038/srep41926

Animals have evolved limb proportions adapted to different environments, but it is not yet clear to what extent these proportions are directly influenced by the environment during prenatal development. The developing skeleton experiences mechanical l... Read More about Limb proportions show developmental plasticity in response to embryo movement.