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All Outputs (235)

Clinical reasoning in canine spinal disease: what combination of clinical information is useful? (2015)
Journal Article
Cardy, T. J. A., De Decker, S., Kenny, P. J., & Volk, H. A. (2015). Clinical reasoning in canine spinal disease: what combination of clinical information is useful?. Veterinary Record, 177(7), https://doi.org/10.1136/vr.102988

Spinal disease in dogs is commonly encountered in veterinary practice. Numerous diseases may cause similar clinical signs and presenting histories. The study objective was to use statistical models to identify combinations of discrete parameters from... Read More about Clinical reasoning in canine spinal disease: what combination of clinical information is useful?.

Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing (2015)
Journal Article
Javaheri, B., Carriero, A., Staines, K. A., Chang, Y. M., Houston, D. A., Oldknow, K. J., …Pitsillides, A. A. (2015). Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing. BONE, 81, 277-291. https://doi.org/10.1016/j.bone.2015.07.035

PHOSPHO1 is one of principal proteins involved in initiating bone matrix mineralisation. Recent studies have found that Phospho1 KO mice (Phospho1-R74X) display multiple skeletal abnormalities with spontaneous fractures, bowed long bones, osteomalaci... Read More about Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing.

Effect of oleic acid supplementation on prostaglandin production in maternal endometrial and fetal allantochorion cells isolated from late gestation ewes (2015)
Journal Article
Cheng, Z. R., Abayasekara, D. R. E., Elmes, M., Kirkup, S. E., & Wathes, D. C. (2015). Effect of oleic acid supplementation on prostaglandin production in maternal endometrial and fetal allantochorion cells isolated from late gestation ewes. Placenta, 36(9), 1011-1017. https://doi.org/10.1016/j.placenta.2015.07.128

Elevated circulating non-esterified fatty acids including oleic acid (OA) are associated with many pregnancy related complications. Prostaglandins (PGs) play crucial roles during parturition. We investigated the effect of OA supplementation on PG pro... Read More about Effect of oleic acid supplementation on prostaglandin production in maternal endometrial and fetal allantochorion cells isolated from late gestation ewes.

Aggregated a-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons (2015)
Journal Article
Reeve, A. K., Ludtmann, M. H. R., Angelova, P. R., Simcox, E. M., Horrocks, M. H., Klenerman, D., …Abramov, A. Y. (2015). Aggregated a-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons. https://doi.org/10.1038/cddis.2015.166

α-Synuclein becomes misfolded and aggregated upon damage by various factors, for example, by reactive oxygen species. These aggregated forms have been proposed to have differential toxicities and their interaction with mitochondria may cause dysfunct... Read More about Aggregated a-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons.

Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation (2015)
Journal Article
Kirkby, N. S., Reed, D. M., Edin, M. L., Rauzi, F., Mataragka, S., Vojnovic, I., …Warner, T. D. (2015). Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation. FASEB Journal, 29(11), 4568-4578. https://doi.org/10.1096/fj.15-275065

Eicosanoids are important vascular regulators, but the phospholipase A2 (PLA2) isoforms supporting their production within the cardiovascular system are not fully understood. To address this, we have studied platelets, endothelial cells, and leukocyt... Read More about Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.

Adolescents care but don't feel responsible for farm animal welfare (2015)
Journal Article
Jamieson, J., Reiss, M. J., Allen, D., Asher, L., Parker, M. O., Wathes, C. M., & Abeyesinghe, S. M. (2015). Adolescents care but don't feel responsible for farm animal welfare. Society and Animals, 23(3), 269-297. https://doi.org/10.1163/15685306-12341283

Adolescents are the next generation of consumers with the potential to raise standards of farm animal welfare—to theirsatisfaction—if their preferences and concerns are translated into accurate market drivers and signals. There are no published data... Read More about Adolescents care but don't feel responsible for farm animal welfare.

HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth (2015)
Journal Article
Blondelle, J., Ohno, Y., Gache, V., Guyot, S., Storck, S., Blanchard-Gutton, N., …Pilot-Storck, F. (2015). HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth. Journal of Molecular Cell Biology, 7(5), 429-440. https://doi.org/10.1093/jmcb/mjv049

The reduced diameter of skeletal myofibres is a hallmark of several congenital myopathies, yet the underlying cellular and molecular mechanisms remain elusive. In this study, we investigate the role of HACD1/PTPLA, which is involved in the elongation... Read More about HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth.

Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts (2015)
Journal Article
Tivers, M. S., Lipscomb, V. J., Smith, K. C., Wheeler-Jones, C. P. D., & House, A. K. (2015). Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts. https://doi.org/10.1016/j.tvjl.2015.07.006

Surgical attenuation of a congenital portosystemic shunt (CPSS) results in increased portal vein perfusion, liver growth and clinical improvement. Portal lipopolysaccharide (LPS) is implicated in liver regeneration via toll-like receptor (TLR) 4 medi... Read More about Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts.

Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation (2015)
Journal Article
Thorpe, C. T., Chaudhry, S., Lei, I., Varone, A., Riley, G. P., Birch, H. L., …Screen, H. R. (2015). Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation. https://doi.org/10.1111/sms.12333

Tendon injury is thought to involve both damage accumulation within the matrix and an accompanying cell response. While several studies have characterized cell and matrix response in chronically injured tendons, few have assessed the initial response... Read More about Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation.

Capture-recapture approaches and the surveillance of livestock diseases: A review (2015)
Journal Article
Vergne, T., Del Rio Vilas, V. J., Cameron, A., Dufour, B., & Grosbois, V. (2015). Capture-recapture approaches and the surveillance of livestock diseases: A review. Preventive Veterinary Medicine, 120(3-4), 253-264. https://doi.org/10.1016/j.prevetmed.2015.04.003

In disease surveillance, capture–recapture approaches have been used to estimate the frequency of endemic diseases monitored by imperfect surveillance systems. A standard output of these techniques is an estimate of the sensitivity of the surveillanc... Read More about Capture-recapture approaches and the surveillance of livestock diseases: A review.

Understanding hind limb lameness signs in horses using simple rigid body mechanics (2015)
Journal Article
Starke, S. D., May, S. A., & Pfau, T. (2015). Understanding hind limb lameness signs in horses using simple rigid body mechanics. Journal of Biomechanics, 48(12), 3323-3331. https://doi.org/10.1016/j.jbiomech.2015.06.019

Hind limb lameness detection in horses relies on the identification of movement asymmetry which can be based on multiple pelvic landmarks. This study explains the poorly understood relationship between hind limb lameness pointers, related to the tube... Read More about Understanding hind limb lameness signs in horses using simple rigid body mechanics.

Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b (2015)
Journal Article
Patterson, R., Nevel, M., Diaz, A. V., Martineau, H. M., Demmers, T. G. M., Browne, C., …Werling, D. (2015). Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b. Veterinary Microbiology, 177(3-4), 261-269. https://doi.org/10.1016/j.vetmic.2015.03.010

Porcine circovirus type 2 (PCV2) has been identified as the essential, but not sole, underlying infectious component for PCV-associated diseases (PCVAD). Several co-factors have been suggested to convert an infection with PCV2 into the clinical signs... Read More about Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b.