Skip to main content

Research Repository

Advanced Search

All Outputs (123)

X Chromosome Evolution in Cetartiodactyla (2017)
Journal Article
Proskuryakova, A. A., Kulemzina, A. I., Perelman, P. L., Makunin, I. A., Larkin, D. M., Farré, M., …Graphodatsky, S. A. (2017). X Chromosome Evolution in Cetartiodactyla. Genes, 8(9), 216. https://doi.org/10.3390/genes8090216

The phenomenon of a remarkable conservation of the X chromosome in eutherian mammals has been first described by Susumu Ohno in 1964. A notable exception is the cetartiodactyl X chromosome, which varies widely in morphology and G-banding pattern betw... Read More about X Chromosome Evolution in Cetartiodactyla.

Elastin is Localised to the Interfascicular Matrix of Energy Storing Tendons and Becomes Increasingly Disorganised With Ageing (2017)
Journal Article
Godinho, M. S., Thorpe, C. T., Greenwald, S. E., & Screen, H. R. (2017). Elastin is Localised to the Interfascicular Matrix of Energy Storing Tendons and Becomes Increasingly Disorganised With Ageing. https://doi.org/10.1038/s41598-017-09995-4

Tendon is composed of fascicles bound together by the interfascicular matrix (IFM). Energy storing tendons are more elastic and extensible than positional tendons; behaviour provided by specialisation of the IFM to enable repeated interfascicular sli... Read More about Elastin is Localised to the Interfascicular Matrix of Energy Storing Tendons and Becomes Increasingly Disorganised With Ageing.

Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs (2017)
Journal Article
Lee, K. C. L., Baker, L., Mallett, S., Riddell, A., Chowdary, P., Alibhai, H. I. K., …Agarwal, B. (2017). Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs. https://doi.org/10.1038/s41598-017-09508-3

Increases in prothrombin time (PT) and international normalised ratio (INR) characterise acute liver injury (ALI) and failure (ALF), yet a wide heterogeneity in clotting abnormalities exists. This study defines evolution of coagulopathy in 10 pigs wi... Read More about Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs.

Comparison of veterinary drugs and veterinary homeopathy: part 2 (2017)
Journal Article
Lees, P., Chambers, D., Pelligand, L., Toutain, P. L., Whiting, M., & Whitehead, M. L. (2017). Comparison of veterinary drugs and veterinary homeopathy: part 2. Veterinary Record, 181, 198-207. https://doi.org/10.1136/vr.104279

Part 2 of this narrative review outlines the theoretical and practical bases for assessing the efficacy and effectiveness of conventional medicines and homeopathic products. Known and postulated mechanisms of action are critically reviewed. The evide... Read More about Comparison of veterinary drugs and veterinary homeopathy: part 2.

Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study (2017)
Journal Article
Kenward, H., Elliott, J., Lee, T., & Pelligand, L. (2017). Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study. BMC Veterinary Research, 13(1), 244. https://doi.org/10.1186/s12917-017-1156-7

Nausea is a subjective sensation which is difficult to measure in non-verbal species. The aims of this study were to determine the efficacy of three classes of antiemetic drugs in a novel low dose cisplatin model of nausea and vomiting and measure ch... Read More about Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study.

A quantitative evaluation of physical and digital approaches to centre of mass estimation (2017)
Journal Article
Macaulay, S., Hutchinson, J. R., & Bates, K. T. (2017). A quantitative evaluation of physical and digital approaches to centre of mass estimation. Journal of Anatomy, 231(5), 758-775. https://doi.org/10.1111/joa.12667

Centre of mass is a fundamental anatomical and biomechanical parameter. Knowledge of centre of mass is essential to inform studies investigating locomotion and other behaviours, through its implications for segment movements, and on whole body factor... Read More about A quantitative evaluation of physical and digital approaches to centre of mass estimation.

Comparison of veterinary drugs and veterinary homeopathy: part 1 (2017)
Journal Article
Lees, P., Chambers, D., Pelligand, L., Toutain, P. L., Whiting, M., & Whitehead, M. L. (2017). Comparison of veterinary drugs and veterinary homeopathy: part 1. Veterinary Record, 181(7), 170-176. https://doi.org/10.1136/vr.104278

For many years after its invention around 1796, homeopathy was widely used in people and later in animals. Over the intervening period (1796-2016) pharmacology emerged as a science from Materia Medica (medicinal materials) to become the mainstay of v... Read More about Comparison of veterinary drugs and veterinary homeopathy: part 1.

Direct activation of NADPH oxidase 2 by 2-deoxyribose-1-phosphate triggers nuclear factor kappa B-dependent angiogenesis. (2017)
Journal Article
Vara, D., Watt, J. M., Fortunato, T. M., Mellor, H., Burgess, M., Wicks, K., …Pula, G. (2017). Direct activation of NADPH oxidase 2 by 2-deoxyribose-1-phosphate triggers nuclear factor kappa B-dependent angiogenesis. https://doi.org/10.1089/ars.2016.6869

AbstractAims: Deoxyribose-1-phosphate (dRP) is a proangiogenic paracrine stimulus released by cancer cells, platelets, and macrophages and acting on endothelial cells. The objective of this study was to clarify how dRP stimulates angiogenic responses... Read More about Direct activation of NADPH oxidase 2 by 2-deoxyribose-1-phosphate triggers nuclear factor kappa B-dependent angiogenesis..

Endothelial SHIP2 suppresses Nox2 NADPH oxidase-dependent vascular oxidative stress, endothelial dysfunction and systemic insulin resistance (2017)
Journal Article
Watt, N. T., Gage, M. C., Patel, P. A., Viswambharan, H., Sukumar, P., Galloway, S., …Cubbon, R. M. (2017). Endothelial SHIP2 suppresses Nox2 NADPH oxidase-dependent vascular oxidative stress, endothelial dysfunction and systemic insulin resistance. Diabetes, 66(11), 2808-2821. https://doi.org/10.2337/db17-0062

Shc homology 2–containing inositol 5′ phosphatase-2 (SHIP2) is a lipid phosphatase that inhibits insulin signaling downstream of phosphatidylinositol 3-kinase (PI3K); its role in vascular function is poorly understood. To examine its role in endothel... Read More about Endothelial SHIP2 suppresses Nox2 NADPH oxidase-dependent vascular oxidative stress, endothelial dysfunction and systemic insulin resistance.

Physiological reactivity to spontaneously occurring seizure activity in dogs with epilepsy and their carers (2017)
Journal Article
Packer, R. M. A., Volk, H. A., & Fowkes, R. C. (2017). Physiological reactivity to spontaneously occurring seizure activity in dogs with epilepsy and their carers. Physiology and Behavior, 177, 27-33. https://doi.org/10.1016/j.physbeh.2017.04.008

There is a complex bidirectional relationship between stress and epilepsy. Stressful stimuli and subsequent cortisol release act as a trigger for seizure activity in some individuals with epilepsy, and seizure activity itself may act as a stressor to... Read More about Physiological reactivity to spontaneously occurring seizure activity in dogs with epilepsy and their carers.

Stable sulforaphane protects against gait anomalies and modifies bone microarchitecture in the spontaneous STR/Ort model of osteoarthritis (2017)
Journal Article
Javaheri, B., Poulet, B., Aljazzar, A., De Souza, R., Piles, M., Hopkinson, M., …Pitsillides, A. A. (2017). Stable sulforaphane protects against gait anomalies and modifies bone microarchitecture in the spontaneous STR/Ort model of osteoarthritis. BONE, 103, 308-317. https://doi.org/10.1016/j.bone.2017.07.028

Osteoarthritis (OA), affecting joints and bone, causes physical gait disability with huge socio-economic burden; treatment remains palliative. Roles for antioxidants in protecting against such chronic disorders have been examined previously. Sulforap... Read More about Stable sulforaphane protects against gait anomalies and modifies bone microarchitecture in the spontaneous STR/Ort model of osteoarthritis.

In search of morphological modules: a systematic review (2017)
Journal Article
Esteve-Altava, B. (2017). In search of morphological modules: a systematic review. Biological Reviews, 92(3), 1332-1347. https://doi.org/10.1111/brv.12284

Morphological modularity arises in complex living beings due to a semi-independent inheritance, development, and function of body parts. Modularity helps us to understand the evolvability and plasticity of organismal form, and how morphological varia... Read More about In search of morphological modules: a systematic review.

Cell cycle-dependent phosphorylation of Theileria annulata schizont surface proteins (2017)
Journal Article
Wiens, O., Xia, D., Von Schubert, C., Wastling, J. M., Dobbelaere, D. A., Heussler, V. T., & Woods, K. L. (2017). Cell cycle-dependent phosphorylation of Theileria annulata schizont surface proteins. PLoS ONE, 9(7), e103821. https://doi.org/10.1371/journal.pone.0103821

The invasion of Theileria sporozoites into bovine leukocytes is rapidly followed by the destruction of the surrounding host cell membrane, allowing the parasite to establish its niche within the host cell cytoplasm. Theileria infection induces host c... Read More about Cell cycle-dependent phosphorylation of Theileria annulata schizont surface proteins.

Tempo and mode of performance evolution across multiple independent origins of adhesive toe pads in lizards (2017)
Journal Article
Hagey, T. J., Uyeda, J. C., Crandell, K. E., Cheney, J. A., Autumn, K., & Harmon, L. J. (2017). Tempo and mode of performance evolution across multiple independent origins of adhesive toe pads in lizards. Evolution, 71(10), 2344-2358. https://doi.org/10.1111/evo.13318

Understanding macroevolutionary dynamics of trait evolution is an important endeavor in evolutionary biology. Ecological opportunity can liberate a trait as it diversifies through trait space, while genetic and selective constraints can limit diversi... Read More about Tempo and mode of performance evolution across multiple independent origins of adhesive toe pads in lizards.

Investigation of the association between serum protein concentrations and concurrent chronic kidney disease in hyperthyroid cats (2017)
Journal Article
Williams, T. L., Elliott, J., Syme, H. M., & Archer, J. (2017). Investigation of the association between serum protein concentrations and concurrent chronic kidney disease in hyperthyroid cats. Research in Veterinary Science, 115, 412-417. https://doi.org/10.1016/j.rvsc.2017.07.023

Our objective was to identify if changes in serum protein concentrations occur in hyperthyroidism and to assess their association with the development of azotaemia following treatment. Initially non-azotaemic hyperthyroid cats and healthy older ca... Read More about Investigation of the association between serum protein concentrations and concurrent chronic kidney disease in hyperthyroid cats.

A distinctive patchy osteomalacia characterises Phospho1-deficient mice (2017)
Journal Article
Boyde, A., Staines, K. A., Javaheri, B., Millan, J. L., Pitsillides, A. A., & Farquharson, C. (2017). A distinctive patchy osteomalacia characterises Phospho1-deficient mice. Journal of Anatomy, 231(2), 293-308. https://doi.org/10.1111/joa.12628

The phosphatase PHOSPHO1 is involved in the initiation of biomineralisation. Bones in Phospho1 knockout (KO) mice show histological osteomalacia with frequent bowing of long bones and spontaneous fractures: they contain less mineral, with smaller min... Read More about A distinctive patchy osteomalacia characterises Phospho1-deficient mice.

Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study (2017)
Journal Article
Hezzell, M. J., Boswood, A., Lopez-Alvarez, J., Lotter, N. S., & Elliott, J. (2017). Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study. Journal of Veterinary Cardiology, 19(4), 325-328. https://doi.org/10.1016/j.jvc.2017.06.001

Spironolactone improves outcome in dogs with advanced myxomatous mitral valve disease (MMVD). Its efficacy in preclinical MMVD is unknown. The hypothesis was the administration of spironolactone to dogs with compensated MMVD demonstrating risk factor... Read More about Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study.