Investigation of the association between serum protein concentrations and concurrent chronic kidney disease in hyperthyroid cats

Williams, T L; Elliott, J; Syme, H M; Archer, J

Abstract

Our objective was to identify if changes in serum protein concentrations occur in hyperthyroidism and to assess their association with the development of azotaemia following treatment.

Initially non-azotaemic hyperthyroid cats and healthy older cats were included. Serum concentrations of protein fractions were determined by agarose gel electrophoresis and compared between; hyperthyroid and control cats, initially non-azotaemic hyperthyroid cats which developed azotaemia in a 4 month follow up period (masked-azotaemic) and those which remained non-azotaemic, and hyperthyroid cats before and at the time of restoration of euthyroidism. Data are presented as median [25th, 75th percentiles].

Hyperthyroid cats (n = 56) had higher serum α2 globulin concentrations (12.5 [10.9, 13.1] g/L vs. 9.8 [3.0, 11.4] g/L; P < 0.001) and lower serum γ globulin concentrations (11.4 [9.1, 13.3] g/L vs. 14.0 [12.4, 16.8] g/L; P = 0.001) than control cats (n = 26). Following treatment, serum total globulin concentration increased (from 38.6 [35.4, 42.8] g/L to 42.3 [39.0, 45.7] g/L; P < 0.001), serum α2 globulin concentration decreased (from 12.5 [10.9, 13.9] g/L to 11.5 [10.1, 12.6] g/L; P < 0.001) and serum γ globulin concentration increased (from 11.4 [9.0, 13.3] g/L to 14.0 [12.4, 16.8] g/L; P < 0.001). Serum concentrations of total globulin or globulin fractions were not significantly different between masked-azotaemic and non azotaemic groups.

In conclusion, hyperthyroidism is associated with altered serum concentrations of the α2 and γ globulin fractions, however these changes were not associated with the development of azotaemic chronic kidney disease following treatment.

Citation

Williams, T. L., Elliott, J., Syme, H. M., & Archer, J. (2017). Investigation of the association between serum protein concentrations and concurrent chronic kidney disease in hyperthyroid cats. Research in Veterinary Science, 115, 412-417. https://doi.org/10.1016/j.rvsc.2017.07.023

• Journal Article Type: Article
• Acceptance Date: Jul 21, 2017
• Publication Date: Jul 24, 2017
• Deposit Date: Aug 2, 2017
• Publicly Available Date: Aug 1, 2018
• Journal: RESEARCH IN VETERINARY SCIENCE
• Print ISSN: 0034-5288
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 115
• Pages: 412-417
• DOI: https://doi.org/10.1016/j.rvsc.2017.07.023
• Public URL: https://rvc-repository.worktribe.com/output/1391131