T L Williams
Investigation of the association between serum protein concentrations and concurrent chronic kidney disease in hyperthyroid cats
Williams, T L; Elliott, J; Syme, H M; Archer, J
H M Syme
Our objective was to identify if changes in serum protein concentrations occur in hyperthyroidism and to assess their association with the development of azotaemia following treatment.
Initially non-azotaemic hyperthyroid cats and healthy older cats were included. Serum concentrations of protein fractions were determined by agarose gel electrophoresis and compared between; hyperthyroid and control cats, initially non-azotaemic hyperthyroid cats which developed azotaemia in a 4 month follow up period (masked-azotaemic) and those which remained non-azotaemic, and hyperthyroid cats before and at the time of restoration of euthyroidism. Data are presented as median [25th, 75th percentiles].
Hyperthyroid cats (n = 56) had higher serum ?2 globulin concentrations (12.5 [10.9, 13.1] g/L vs. 9.8 [3.0, 11.4] g/L; P < 0.001) and lower serum ? globulin concentrations (11.4 [9.1, 13.3] g/L vs. 14.0 [12.4, 16.8] g/L; P = 0.001) than control cats (n = 26). Following treatment, serum total globulin concentration increased (from 38.6 [35.4, 42.8] g/L to 42.3 [39.0, 45.7] g/L; P < 0.001), serum ?2 globulin concentration decreased (from 12.5 [10.9, 13.9] g/L to 11.5 [10.1, 12.6] g/L; P < 0.001) and serum ? globulin concentration increased (from 11.4 [9.0, 13.3] g/L to 14.0 [12.4, 16.8] g/L; P < 0.001). Serum concentrations of total globulin or globulin fractions were not significantly different between masked-azotaemic and non azotaemic groups.
In conclusion, hyperthyroidism is associated with altered serum concentrations of the ?2 and ? globulin fractions, however these changes were not associated with the development of azotaemic chronic kidney disease following treatment.
Williams, T. L., Elliott, J., Syme, H. M., & Archer, J. (2017). Investigation of the association between serum protein concentrations and concurrent chronic kidney disease in hyperthyroid cats. Research in Veterinary Science, 115, 412-417. https://doi.org/10.1016/j.rvsc.2017.07.023
|Journal Article Type||Article|
|Acceptance Date||Jul 21, 2017|
|Publication Date||Jul 24, 2017|
|Deposit Date||Aug 2, 2017|
|Publicly Available Date||Jul 25, 2018|
|Journal||RESEARCH IN VETERINARY SCIENCE|
|Peer Reviewed||Peer Reviewed|
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