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Observational Study Design in Veterinary Pathology, Part 2: Methodology (2018)
Journal Article
Caswell, J. L., Bassel, L. L., Rothenburger, J. L., Gröne, A., Sargeant, J. M., Beck, A. P., …Yamate, J. (2018). Observational Study Design in Veterinary Pathology, Part 2: Methodology. Veterinary Pathology, 55(6), 774-785. https://doi.org/10.1177/0300985818798121

Observational studies are a basis for much of our knowledge of veterinary pathology, yet considerations for conducting pathology-based observational studies are not readily available. In part 1 of this series, we offered advice on planning and carryi... Read More about Observational Study Design in Veterinary Pathology, Part 2: Methodology.

The scaling or ontogeny of human gait kinetics and walk-run transition: The implications of work vs. peak power minimization (2018)
Journal Article
Usherwood, J. R., Hubel, T. Y., Smith, B. J. H., Self Davies, Z. T., & Sobota, G. (2018). The scaling or ontogeny of human gait kinetics and walk-run transition: The implications of work vs. peak power minimization. Journal of Biomechanics, 81, 12-21. https://doi.org/10.1016/j.jbiomech.2018.09.004

A simple model is developed to find vertical force profiles and stance durations that minimize either limb mechanical work or peak power demands during bipedal locomotion. The model predicts that work minimization is achieved with a symmetrical verti... Read More about The scaling or ontogeny of human gait kinetics and walk-run transition: The implications of work vs. peak power minimization.

HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa (2018)
Journal Article
Di Rita, A., Peschiaroli, A., D'Acunzo, P., Strobbe, D., Hu, Z., Gruber, J., …Cecconi, F. (2018). HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa. Nature Communications, 9(3755), https://doi.org/10.1038/s41467-018-05722-3

The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing. The pro-autophagic molecule AMBRA1 (autophagy/beclin-1 reg... Read More about HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa.

C-Type Natriuretic Peptide (CNP) Inhibition of Interferon-γ-Mediated Gene Expression in Human Endothelial Cells In Vitro (2018)
Journal Article
Day, A., Jameson, Z., Hyde, C., Simbi, B. H., Fowkes, R. C., & Lawson, C. (2018). C-Type Natriuretic Peptide (CNP) Inhibition of Interferon-γ-Mediated Gene Expression in Human Endothelial Cells In Vitro. Biosensors, 8(3), https://doi.org/10.3390/bios8030086

Cardiovascular diseases, including atherosclerosis, now account for more deaths in the Western world than from any other cause. Atherosclerosis has a chronic inflammatory component involving Th1 pro-inflammatory cytokines such as IFN-γ, which is know... Read More about C-Type Natriuretic Peptide (CNP) Inhibition of Interferon-γ-Mediated Gene Expression in Human Endothelial Cells In Vitro.

The dynamic role of the ilio-sacral joint in jumping frogs (2018)
Journal Article
Richards, C. T., Eberhard, E. A., & Collings, A. J. (2018). The dynamic role of the ilio-sacral joint in jumping frogs. Biology Letters, 14(9), https://doi.org/10.1098/rsbl.2018.0367

A striking feature among jumping frogs is a sharp pelvic bend about the ilio-sacral (IS) joint, unique to anurans. Although this sagittal plane hinge has been interpreted as crucial for the evolution of jumping, its mechanical contribution has not be... Read More about The dynamic role of the ilio-sacral joint in jumping frogs.

Toxoplasma gondii profilin does not stimulate an innate immune response through bovine or human TLR5 (2018)
Journal Article
Tombacz, K., Burgess, G., Holder, A. L., Werners, A., & Werling, D. (2018). Toxoplasma gondii profilin does not stimulate an innate immune response through bovine or human TLR5. Innate Immunity, https://doi.org/10.1177/1753425918798450

Toxoplasma gondii is responsible for one of the most prevalent infections in people. T. gondii profilin (TgPr) is a protein integral to parasite movement and cellular invasion. Murine TLR has been described to bind TgPr. Furthermore, more recently, h... Read More about Toxoplasma gondii profilin does not stimulate an innate immune response through bovine or human TLR5.

Mapping Nairobi's dairy food system: An essential analysis for policy, industry and research (2018)
Journal Article
Kiambi, S., Alarcon, P., Rushton, J., Murungi, M. K., Muinde, P., Akoko, J., …Fèvre, E. M. (2018). Mapping Nairobi's dairy food system: An essential analysis for policy, industry and research. Agricultural Systems, 167, 47-60. https://doi.org/10.1016/j.agsy.2018.08.007

Demand for dairy products in sub-Saharan Africa, is expected to triple by 2050, while limited increase in supply is predicted. This poses significant food security risk to low income households. Understanding how the dairy food system operates is ess... Read More about Mapping Nairobi's dairy food system: An essential analysis for policy, industry and research.

Mortalities, amyloidosis and other diseases in free-living red squirrels (Sciurus vulgaris) on Jersey, Channel Islands (2018)
Journal Article
Blackett, T. A., Simpson, V. R., Haugland, S., Everest, D. J., Muir, C. F., & Smith, K. C. M. A. C. (2018). Mortalities, amyloidosis and other diseases in free-living red squirrels (Sciurus vulgaris) on Jersey, Channel Islands. Veterinary Record, https://doi.org/10.1136/vr.104779

Between 2007 and 2014, 337 free-living red squirrels (Sciurus vulgaris) on Jersey, Channel Islands, were examined post mortem as part of a mortality and disease surveillance scheme. Road traffic accidents (RTAs) were attributable for 50.7 per cent (1... Read More about Mortalities, amyloidosis and other diseases in free-living red squirrels (Sciurus vulgaris) on Jersey, Channel Islands.

The type of adjuvant in whole inactivated influenza a virus vaccines impacts vaccine-associated enhanced respiratory disease (2018)
Journal Article
Souza, C. K., Rajão, D. S., Sandbulte, M. R., Lopes, S., Lewis, N. S., Loving, C. L., …Vincent, A. L. (2018). The type of adjuvant in whole inactivated influenza a virus vaccines impacts vaccine-associated enhanced respiratory disease. Vaccine, 36(41), 6103-6110. https://doi.org/10.1016/j.vaccine.2018.08.072

Influenza A virus (IAV) causes a disease burden in the swine industry in the US and is a challenge to prevent due to substantial genetic and antigenic diversity of IAV that circulate in pig populations. Whole inactivated virus (WIV) vaccines formulat... Read More about The type of adjuvant in whole inactivated influenza a virus vaccines impacts vaccine-associated enhanced respiratory disease.

A culture-independent method for studying transfer of IncI1 plasmids from wild-type Escherichia coli in complex microbial communities (2018)
Journal Article
Anjum, M., Madsen, J. S., Espinosa-Gongora, C., Jana, B., Wiese, M., Nielsen, D. S., …Guardabassi, L. (2018). A culture-independent method for studying transfer of IncI1 plasmids from wild-type Escherichia coli in complex microbial communities. Journal of Microbiological Methods, 152, 18-26. https://doi.org/10.1016/j.mimet.2018.07.009

IncI1 plasmids play a central role in the transfer of antimicrobial resistance genes among Enterobacteriaceae in animals and humans. Knowledge on the dynamics of IncI1 plasmid transfer is limited, mainly due to lack of culture-independent methods tha... Read More about A culture-independent method for studying transfer of IncI1 plasmids from wild-type Escherichia coli in complex microbial communities.

Cutaneous Botryomycosis in Two Pet Rabbits (2018)
Journal Article
Hedley, J., Stapleton, N., Muir, C., Priestnall, S. L., & Smith, K. (2018). Cutaneous Botryomycosis in Two Pet Rabbits. Journal of Exotic Pet Medicine, 28, 143-147. https://doi.org/10.1053/j.jepm.2018.01.005

A 5-year-old male neutered rabbit was presented for assessment of multiple abscesses, which had appeared suddenly over the ventrum, perineum and hindlimbs over the previous few days. Thirteen abscesses were surgically excised. Culture revealed Pseudo... Read More about Cutaneous Botryomycosis in Two Pet Rabbits.

Scans for signatures of selection in Russian cattle breed genomes reveal new candidate genes for environmental adaptation and acclimation (2018)
Journal Article
Yurchenko, A. A., Daetwyler, H. D., Yudin, N., Schnabel, R. D., Vander Jagt, C. J., Soloshenko, V., …Larkin, D. M. (2018). Scans for signatures of selection in Russian cattle breed genomes reveal new candidate genes for environmental adaptation and acclimation. https://doi.org/10.1038/s41598-018-31304-w

Domestication and selective breeding has resulted in over 1000 extant cattle breeds. Many of these breeds do not excel in important traits but are adapted to local environments. These adaptations are a valuable source of genetic material for efforts... Read More about Scans for signatures of selection in Russian cattle breed genomes reveal new candidate genes for environmental adaptation and acclimation.

Rodents of Senegal and their role as intermediate hosts of Hydatigera spp. (Cestoda: Taeniidae) (2018)
Journal Article
Catalano, S., Bâ, K., Diouf, N., Léger, E., Verocai, G., & Webster, J. P. (2018). Rodents of Senegal and their role as intermediate hosts of Hydatigera spp. (Cestoda: Taeniidae). Parasitology, 146(3), 299-304. https://doi.org/10.1017/S0031182018001427

Hydatigera (Cestoda: Taeniidae) is a recently resurrected genus including species seldom investigated in sub-Saharan Africa. We surveyed wild small mammal populations in the areas of Richard Toll and Lake Guiers, Senegal, with the objective to evalua... Read More about Rodents of Senegal and their role as intermediate hosts of Hydatigera spp. (Cestoda: Taeniidae).