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NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells (2019)
Journal Article
Jones, L. G., Vaisa, A., Thompson, L. M., Ikuomola, F. I., Caamaño, J. H., Burkitt, M. D., …Duckworth, C. A. (2019). NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells. https://doi.org/10.1038/s41419-019-2129-5

Alternative pathway NF-κB signalling regulates susceptibility towards developing inflammatory bowel disease (IBD), colitis-associated cancer and sepsis-associated intestinal epithelial cell apoptosis and shedding. However, the cell populations respon... Read More about NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells.

Molecular Characterization of Group A Rotavirus from Rhesus Macaques (Macaca mulatta) at Human-Wildlife Interfaces in Bangladesh (2019)
Journal Article
Islam, A., Hossain, M. E., Haider, N., Rostal, M. K., Mukharjee, S. K., Ferdous, J., …Epstein, J. H. (2019). Molecular Characterization of Group A Rotavirus from Rhesus Macaques (Macaca mulatta) at Human-Wildlife Interfaces in Bangladesh. Transboundary and Emerging Diseases, https://doi.org/10.1111/tbed.13431

Group A rotavirus (RVA) is an important cause of diarrhea in people, especially children, and animals globally. Due to the segmented nature of the RVA genome, animal RVA strains have the potential to adapt to the human host through re‐assortment with... Read More about Molecular Characterization of Group A Rotavirus from Rhesus Macaques (Macaca mulatta) at Human-Wildlife Interfaces in Bangladesh.

Species-specific consequences of an E40K missense mutation in superoxide dismutase 1 (SOD1) (2019)
Journal Article
Draper, A. C. E., Wilson, Z., Maile, C. A., Faccenda, D., Campanella, M., & Piercy, R. J. (2019). Species-specific consequences of an E40K missense mutation in superoxide dismutase 1 (SOD1). FASEB Journal, https://doi.org/10.1096/fj.201901455R

A glutamic acid to lysine (E40K) residue substitution in superoxide dismutase 1 (SOD1) is associated with canine degenerative myelopathy: the only naturally occurring large animal model of amyotrophic lateral sclerosis (ALS). The E40 residue is highl... Read More about Species-specific consequences of an E40K missense mutation in superoxide dismutase 1 (SOD1).

Prognostic Factors for Recovery of Vision in Canine Optic Neuritis of Unknown Etiology: 26 Dogs (2003–2018) (2019)
Journal Article
Posporis, C., Beltran, E., Dunning, M., Espadas, I., Gillespie, S., Barry, A. T., & Wessmann, A. (2019). Prognostic Factors for Recovery of Vision in Canine Optic Neuritis of Unknown Etiology: 26 Dogs (2003–2018). Frontiers in Veterinary Science, 6, https://doi.org/10.3389/fvets.2019.00415

Optic neuritis (ON) is a recognized condition, yet factors influencing recovery of vision are currently unknown. The purpose of this study was to identify prognostic factors for recovery of vision in canine ON of unknown etiology. Clinical databases... Read More about Prognostic Factors for Recovery of Vision in Canine Optic Neuritis of Unknown Etiology: 26 Dogs (2003–2018).

The Ethics of Laying Hen Genetics (2019)
Journal Article
Fernyhough, M., Nicol, C. J., Van De Braak, T., Toscano, M. J., & Tønnessen, M. (2019). The Ethics of Laying Hen Genetics. https://doi.org/10.1007/s10806-019-09810-2

Despite societal concerns about the welfare of commercial laying hens, little attention has been paid to the welfare implications of the choices made by the genetics companies involved with their breeding. These choices regarding trait selection and... Read More about The Ethics of Laying Hen Genetics.

Risk-based surveillance for meat-borne parasites (2019)
Journal Article
Alban, L., Haesler, B., Van Schaik, G., & Ruegg, S. (2019). Risk-based surveillance for meat-borne parasites. Experimental Parasitology, 208, https://doi.org/10.1016/j.exppara.2019.107808

There is a plethora of meat-borne hazards – including parasites - for which there may be a need for surveillance. However, veterinary services worldwide need to decide how to use their scarce resources and prioritise among the perceived hazards. More... Read More about Risk-based surveillance for meat-borne parasites.

Charcot-Marie-Tooth type 4B2 demyelinating neuropathy in miniature Schnauzer dogs caused by a novel splicing SBF2 (MTMR13) genetic variant: a new spontaneous clinical model (2019)
Journal Article
Granger, N., Feliu-Pascual, A., Spicer, C., Ricketts, S., Hitti, R., Forman, O., …Houlden, H. (2019). Charcot-Marie-Tooth type 4B2 demyelinating neuropathy in miniature Schnauzer dogs caused by a novel splicing SBF2 (MTMR13) genetic variant: a new spontaneous clinical model. PeerJ, 7, e7983. https://doi.org/10.7717/peerj.7983

This study reports the first genetic variant in Miniature Schnauzer dogs responsible for the occurrence of a demyelinating peripheral neuropathy with abnormally folded myelin. This discovery establishes a genotype/phenotype correlation in affected Mi... Read More about Charcot-Marie-Tooth type 4B2 demyelinating neuropathy in miniature Schnauzer dogs caused by a novel splicing SBF2 (MTMR13) genetic variant: a new spontaneous clinical model.

Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential (2019)
Journal Article
Sharma, A., Goring, A., Staines, K. A., Emery, R., Pitsillides, A. A., Oreffo, R. O. C., …Clarkin, C. E. (2019). Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential. Matrix Biology, 5, https://doi.org/10.1016/j.mbplus.2019.100018

Mineralization of bone is achieved by the sequential maturation of the immature amorphous calcium phase to mature hydroxyapatite and is central to the process of bone development and repair. To study normal and dysregulated mineralization in vitro, s... Read More about Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential.

Light-based monitoring devices to assess range use by laying hens (2019)
Journal Article
Buijis, S., Nicol, C. J., Booth, F., Richards, G., & Tarlton, J. F. (2019). Light-based monitoring devices to assess range use by laying hens. animal, 14(4), 814-823. https://doi.org/10.1017/S1751731119002830

Access to an outdoor range has many potential benefits for laying hens but range use can be poor due to factors only partly understood. Techniques to monitor individual range use within commercial flocks are crucial to increase our understanding of t... Read More about Light-based monitoring devices to assess range use by laying hens.

Life cycle stages, specific organelles and invasion mechanisms of Eimeria species (2019)
Journal Article
Burrell, A., Tomley, F. M., Vaughan, S., & Marugan-Hernandez, V. (2019). Life cycle stages, specific organelles and invasion mechanisms of Eimeria species. Parasitology, https://doi.org/10.1017/S0031182019001562

Apicomplexans, including species of Eimeria, pose a real threat to the health and wellbeing of animals and humans. Eimeria parasites do not infect humans but cause an important economic impact on livestock, in particular on the poultry industry. Desp... Read More about Life cycle stages, specific organelles and invasion mechanisms of Eimeria species.

The role of chick Ebf genes in the mediolateral patterning of the somites (2019)
Journal Article
EL-Magd, M. A., Elsayed, S. A., El-Shetry, E. S., Abdelfattah-Hassan, A., Saleh, A. A., Allen, S., …Patel, K. (2019). The role of chick Ebf genes in the mediolateral patterning of the somites. https://doi.org/10.1002/dvg.23339

This study was conducted to check whether the three chick Early B‐cell Factor (Ebf) genes, particularly cEbf1, would be targets for Shh and Bmp signals during somites mediolateral (ML) patterning. Tissue manipulations and gain and loss of function ex... Read More about The role of chick Ebf genes in the mediolateral patterning of the somites.

Can skeletal surface area predict in vivo foot surface area? (2019)
Journal Article
Strickson, E. C., Hutchinson, J. R., Wilkinson, D. M., & Falkingham, P. L. (2019). Can skeletal surface area predict in vivo foot surface area?. Journal of Anatomy, https://doi.org/10.1111/joa.13090

The surface area of feet in contact with the ground is a key morphological feature that influences animal locomotion. Underfoot pressures (and consequently stresses experienced by the foot), as well as stability of an animal during locomotion, depend... Read More about Can skeletal surface area predict in vivo foot surface area?.

Approaching ancient disease from a One Health perspective: interdisciplinary review for the investigation of zoonotic brucellosis (2019)
Journal Article
Bendrey, R., Cassidy, J., Fournié, G., Merrett, D. C., Oakes, R., & Taylor, M. (2019). Approaching ancient disease from a One Health perspective: interdisciplinary review for the investigation of zoonotic brucellosis. International Journal of Osteoarchaeology, https://doi.org/10.1002/oa.2837

Today, brucellosis is the most common global bacterial zoonosis, bringing with it a range of significant health and economic consequences, yet it is rarely identified from the archaeological record. Detection and understanding of past zoonoses could... Read More about Approaching ancient disease from a One Health perspective: interdisciplinary review for the investigation of zoonotic brucellosis.

Assessment on the adoption of recommended standards, novel approaches and best practices for animal health surveillance by decision makers in Europe (2019)
Journal Article
Haesler, B., Garza, M., Bisdorff, B., Leger, A., Tavornpanich, S., Peyre, M., …Staerk, K. D. (2019). Assessment on the adoption of recommended standards, novel approaches and best practices for animal health surveillance by decision makers in Europe. Frontiers in Veterinary Science, https://doi.org/10.3389/fvets.2019.00375

Animal health surveillance is an important tool for disease mitigation and helps to promote animal health and welfare, protect human health, support efficient animal production, and enable trade. This study aimed to assess adoption of recommended sta... Read More about Assessment on the adoption of recommended standards, novel approaches and best practices for animal health surveillance by decision makers in Europe.