All Outputs (3)

Comparison of surgical indications and short- and long-term complications in 56 cats undergoing perineal, transpelvic or prepubic urethrostomy (2020)
Journal Article
Seneviratne, M., Stamenova, P., & Lee, K. (2020). Comparison of surgical indications and short- and long-term complications in 56 cats undergoing perineal, transpelvic or prepubic urethrostomy. Journal of Feline Medicine and Surgery, 1098612X2095903. https://doi.org/10.1177/1098612X20959032

Objectives
The aim of this study was to compare indications, complications and mortality rates for perineal urethrostomy (PU), transpelvic urethrostomy (TPU) and prepubic urethrostomy (PPU).

Methods
A retrospective review of, and follow-up owner... Read More about Comparison of surgical indications and short- and long-term complications in 56 cats undergoing perineal, transpelvic or prepubic urethrostomy.

The analysis of acetaminophen (paracetamol) and seven metabolites in rat, pig and human plasma by U(H)PLC–MS (2020)
Journal Article
Dargue, R., Grant, I., Nye, L. C., Nicholls, A., Dare, T., Stahl, S. H., Plumb, R. S., & Lee, K. C. L. (2020). The analysis of acetaminophen (paracetamol) and seven metabolites in rat, pig and human plasma by U(H)PLC–MS. Bioanalysis, 12(7), https://doi.org/10.4155/bio-2020-0015

A U(H)PLC–MS/MS method is described for the analysis of acetaminophen and its sulphate, glucuronide, glutathione, cysteinyl and N-acetylcysteinyl metabolites in plasma using stable isotope-labeled internal standards. P-Aminophenol glucuronide and 3-m... Read More about The analysis of acetaminophen (paracetamol) and seven metabolites in rat, pig and human plasma by U(H)PLC–MS.

Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure (2020)
Journal Article
Dargue, R., Zia, R., Lau, C., Nicholls, A. W., Dare, T. O., Lee, K. C. L., Jalan, R., Coen, M., & Wilson, I. D. (2020). Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure. Toxicological Sciences, https://doi.org/10.1093/toxsci/kfaa023

The metabolic fate, toxicity and effects on endogenous metabolism of paracetamol (acetaminophen, APAP) in 22 female Landrace cross large white pigs were evaluated in a model of acute liver failure (ALF). Anaesthetized pigs were initially dosed at 250... Read More about Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure.