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Natriuretic peptide expression and function in GH3 somatolactotropes and feline somatotrope pituitary tumors (2021)
Journal Article
Mirczuk, S., Scudder, C., Read, J., Crossley, V., Regan, J., Richardson, K., …Fowkes, R. (2021). Natriuretic peptide expression and function in GH3 somatolactotropes and feline somatotrope pituitary tumors. International Journal of Molecular Sciences, -. https://doi.org/10.3390/ijms22031076

Patients harbouring mutations in genes encoding C-type natriuretic peptide (CNP; NPPC) or its receptor guanylyl cyclase B (GC-B, NPR2) suffer from severe growth phenotypes; loss-of-function mutations cause achondroplasia, whereas gain-of-function mut... Read More about Natriuretic peptide expression and function in GH3 somatolactotropes and feline somatotrope pituitary tumors.

Dysregulated cell signalling and reduced satellite cell potential in ageing muscle (2019)
Journal Article
Patel, K., Simbi, B. H., Ritvos, O., Vaiyapuri, S., & Dhoot, G. K. (2019). Dysregulated cell signalling and reduced satellite cell potential in ageing muscle. Experimental Cell Research, 385(2), https://doi.org/10.1016/j.yexcr.2019.111685

Aberrant activation of signalling pathways has been postulated to promote age related changes in skeletal muscle. Cell signalling activation requires not only the expression of ligands and receptors but also an appropriate environment that facilitate... Read More about Dysregulated cell signalling and reduced satellite cell potential in ageing muscle.

Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes (2014)
Journal Article
Thompson, I. R., Mirczuk, S. M., Smith, L., Lessey, A. J., Simbi, B., Sunters, A., …Fowkes, R. C. (2014). Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes. Cell and Tissue Research, 355(2), 425-36. https://doi.org/10.1007/s00441-013-1763-y

The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models... Read More about Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes.

Neuromuscular stimulation causes muscle phenotype-dependent changes in the expression of the IGFs and their binding proteins in developing slow and fast muscle of chick embryos
Journal Article
McEntee, G. M., Simbi, B. H., Bayol, S. A. M., Macharia, R. G., & Stickland, N. C. Neuromuscular stimulation causes muscle phenotype-dependent changes in the expression of the IGFs and their binding proteins in developing slow and fast muscle of chick embryos. Developmental Dynamics, 235(7), 1777-1784. https://doi.org/10.1002/dvdy.20803

Larval programming of post-hatch muscle growth and activity in Atlantic salmon (Salmo salar)
Journal Article
Albokhadaim, I., Hammond, C. L., Ashton, C., Simbi, B. H., Bayol, S. A. M., Farrington, S. J., & Stickland, N. (in press). Larval programming of post-hatch muscle growth and activity in Atlantic salmon (Salmo salar). Journal of Experimental Biology, 210(10), 1735-1741. https://doi.org/10.1242/jeb.003194

Larval muscle development in Atlantic salmon is known to be affected by temperature; however, the long term effects and possible mechanisms involved are less well understood. Therefore, the aim of this study was to evaluate the influence of egg incub... Read More about Larval programming of post-hatch muscle growth and activity in Atlantic salmon (Salmo salar).

Evidence that a maternal "junk food" diet during pregnancy and lactation can reduce muscle force in offspring
Journal Article
Bayol, S. A. M., Macharia, R. G., Farrington, S. J., Simbi, B. H., & Stickland, N. C. Evidence that a maternal "junk food" diet during pregnancy and lactation can reduce muscle force in offspring. European Journal of Nutrition, 48(1), 62-65. https://doi.org/10.1007/s00394-008-0760-5

Obesity is a multi-factorial condition generally attributed to an unbalanced diet and lack of exercise. Recent evidence suggests that maternal malnutrition during pregnancy and lactation can also contribute to the development of obesity in offspring.... Read More about Evidence that a maternal "junk food" diet during pregnancy and lactation can reduce muscle force in offspring.

Offspring from mothers fed a 'junk food' diet in pregnancy and lactation exhibit exacerbated adiposity that is more pronounced in females
Journal Article
Bayol, S. A. M., Simbi, B. H., Bertrand, J. A., & Stickland, N. C. Offspring from mothers fed a 'junk food' diet in pregnancy and lactation exhibit exacerbated adiposity that is more pronounced in females. Journal of Physiology, 586(13), 3219-3230. https://doi.org/10.1113/jphysiol.2008.153817

We have shown previously that a maternal junk food diet during pregnancy and lactation plays a role in predisposing offspring to obesity. Here we show that rat offspring born to mothers fed the same junk food diet rich in fat, sugar and salt develop... Read More about Offspring from mothers fed a 'junk food' diet in pregnancy and lactation exhibit exacerbated adiposity that is more pronounced in females.