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Dysregulated cell signalling and reduced satellite cell potential in ageing muscle

Patel, K; Simbi, B H; Ritvos, O; Vaiyapuri, S; Dhoot, G K


K Patel

B H Simbi

O Ritvos

S Vaiyapuri

G K Dhoot


Aberrant activation of signalling pathways has been postulated to promote age related changes in skeletal muscle. Cell signalling activation requires not only the expression of ligands and receptors but also an appropriate environment that facilitates their interaction. Here we first examined the expression of SULF1/SULF2 and members of RTK (receptor tyrosine kinase) and the Wnt family in skeletal muscle of normal and a mouse model of accelerated ageing. We show that SULF1/SULF2 and these signalling components, a feature of early muscle development are barely detectable in early postnatal muscle. Real time qPCR and immunocytochemical analysis showed gradual but progressive up-regulation of SULF1/SULF2 and RTK/Wnt proteins not only in the activated satellite cells but also on muscle fibres that gradually increased with age. Satellite cells on isolated muscle fibres showed spontaneous in vivo satellite cell activation and progressive reduction in proliferative potential and responsiveness to HGF (hepatocyte growth factor) and dysregulated myogenic differentiation with age. Finally, we show that SULF1/SULF2 and RTK/Wnt signalling components are expressed in progeric mouse muscles at earlier stage but their expression is attenuated by an intervention that promotes muscle repair and growth.


Patel, K., Simbi, B. H., Ritvos, O., Vaiyapuri, S., & Dhoot, G. K. (2019). Dysregulated cell signalling and reduced satellite cell potential in ageing muscle. Experimental Cell Research, 385(2),

Journal Article Type Article
Acceptance Date Oct 19, 2019
Publication Date Oct 21, 2019
Deposit Date Oct 22, 2019
Publicly Available Date Oct 22, 2020
Journal Experimental Cell Research
Print ISSN 0014-4827
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 385
Issue 2
Public URL


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