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The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity (2021)
Journal Article
Frison, M., Faccenda, D., Abeti, R., Rigon, M., Strobbe, D., England-Rendon, B., …Campanella, M. (2021). The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity. Molecular Psychiatry, 26(7), 2721-2739. https://doi.org/10.1038/s41380-021-01050-z

Dysfunctional mitochondria characterise Parkinson's Disease (PD). Uncovering etiological molecules, which harm the homeostasis of mitochondria in response to pathological cues, is therefore pivotal to inform early diagnosis and therapy in the conditi... Read More about The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity.

Pharmacological advances in mitochondrial therapy (2021)
Journal Article
Singh, A., Faccenda, D., & Campanella, M. (2021). Pharmacological advances in mitochondrial therapy. EBioMedicine, 65, https://doi.org/10.1016/j.ebiom.2021.103244

Mitochondria play a vital role in cellular metabolism and are central mediator of intracellular signalling, cell differentiation, morphogenesis and demise. An increasingly higher number of pathologies is linked with mitochondrial dysfunction, which c... Read More about Pharmacological advances in mitochondrial therapy.

Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response (2020)
Journal Article
Desai, R., East, D. A., Hardy, L., Crosby, J., Faccenda, D., Alvarex, M. S., …Campanella, M. (2020). Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response. Science Advances, https://doi.org/10.1101/445411

Cholesterol metabolism is pivotal to cellular homeostasis, hormones production, and membranes composition. Its dysregulation associates with malignant reprogramming and therapy resistance. Cholesterol is trafficked into the mitochondria for steroidog... Read More about Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response.

The ATPase Inhibitory Factor 1 (IF1) regulates the expression of the mitochondrial Ca2+ uniporter (MCU) via the AMPK/CREB pathway (2020)
Journal Article
Faccenda, D., Gorini, G., Jones, A., Thornton, C., Baracca, A., Solaini, G., & Campanella, M. (2020). The ATPase Inhibitory Factor 1 (IF1) regulates the expression of the mitochondrial Ca2+ uniporter (MCU) via the AMPK/CREB pathway

•IF1 regulates MCU-dependent mitochondrial Ca2+ uptake. •IF1 loss induces MCU upregulation through activation of the AMPK/CREB pathway. •OMA1 depletion restores physiological MCU levels and mitochondrial Ca2+ entry.

Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75 (2018)
Journal Article
D'Eletto, M., Rossin, F., Occhigrossi, L., Farrace, M. G., Faccenda, D., Desai, R., …Piacentini, M. (2018). Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75. Cell Reports, 25(12), 3573-3581. https://doi.org/10.1016/j.celrep.2018.11.094

Transglutaminase type 2 (TG2) is a multifunctional enzyme that plays a key role in mitochondria homeostasis under stressful cellular conditions. TG2 interactome analysis reveals an enzyme interaction with GRP75 (glucose-regulated protein 75). GRP75 l... Read More about Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75.

Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates (2018)
Journal Article
Martin-Jimenez, R., Faccenda, D., Allen, E., Reichel, H. B., Arcos, L., Ferraina, C., …Campanella, M. (2018). Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates. https://doi.org/10.1038/s41419-018-0578-x

In vertebrates, mitochondria are tightly preserved energy producing organelles, which sustain nervous system development and function. The understanding of proteins that regulate their homoeostasis in complex animals is therefore critical and doing s... Read More about Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates.

Control of Mitochondrial Remodeling by the ATPase Inhibitory Factor 1 Unveils a Pro-survival Relay via OPA1 (2017)
Journal Article
Faccenda, D., Nakamura, J., Gorini, G., Dhoot, G. K., Piacentini, M., Yoshida, M., & Campanella, M. (2017). Control of Mitochondrial Remodeling by the ATPase Inhibitory Factor 1 Unveils a Pro-survival Relay via OPA1. Cell Reports, https://doi.org/10.1016/j.celrep.2017.01.070

The ubiquitously expressed ATPase inhibitory factor 1 (IF1) is a mitochondrial protein that blocks the reversal of the F1Fo-ATPsynthase, preventing dissipation of cellular ATP and ischemic damage. IF1 suppresses programmed cell death, enhancing tumor... Read More about Control of Mitochondrial Remodeling by the ATPase Inhibitory Factor 1 Unveils a Pro-survival Relay via OPA1.