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Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy (2017)
Journal Article
Georgakopoulos, N. D., Frison, M., Alvarez, M. S., Bertrand, H., Wells, G., & Campanella, M. (2017). Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy. https://doi.org/10.1038/s41598-017-07679-7

Mitophagy orchestrates the autophagic degradation of dysfunctional mitochondria preventing their pathological accumulation and contributing to cellular homeostasis. We previously identified a novel chemical tool (hereafter referred to as PMI), which... Read More about Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy.

A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling (2017)
Journal Article
Gatliff, J., East, D. A., Singh, A., Alvarez, M. S., Frison, M., Matic, I., …Campanella, M. (2017). A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling. https://doi.org/10.1038/cddis.2017.186

The 18?kDa translocator protein TSPO localizes on the outer mitochondrial membrane (OMM). Systematically overexpressed at sites of neuroinflammation it is adopted as a biomarker of brain conditions. TSPO inhibits the autophagic removal of mitochondri... Read More about A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling.

Controlled and Impaired Mitochondrial Quality in Neurons: Molecular Physiology and Prospective Pharmacology
Journal Article
Matic, I., Strobbe, D., Frison, M., & Campanella, M. (in press). Controlled and Impaired Mitochondrial Quality in Neurons: Molecular Physiology and Prospective Pharmacology. Pharmacological Research, 99, 410-424. https://doi.org/10.1016/j.phrs.2015.03.021

Tuned mitochondrial physiology is fundamental for qualitative cellular function. This is particularly relevant for neurons, whose pathology is frequently associated with mitochondrial deficiencies. Defects in mitochondria are indeed key features in m... Read More about Controlled and Impaired Mitochondrial Quality in Neurons: Molecular Physiology and Prospective Pharmacology.