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Outputs (27)

Schistosomiasis — Assessing Progress toward the 2020 and 2025 Global Goals (2019)
Journal Article
Deol, A. K., Fleming, F. M., Calvo-Urbano, B., Walker, M., Bucumi, V., Gnandou, I., Tukahebwa, E. M., Jemu, S., Mwingira, U. J., Alkohlani, A., Traoré, M., Ruberanziza, E., Touré, S., Basáñez, M.-G., French, M. D., & Webster, J. P. (2019). Schistosomiasis — Assessing Progress toward the 2020 and 2025 Global Goals. New England Journal of Medicine, 381, 2519-2528. https://doi.org/10.1056/NEJMoa1812165

Precision mapping of snail habitat provides a powerful indicator of human schistosomiasis transmission (2019)
Journal Article
Wood, C. L., Sokolow, S. H., Jones, I. J., Chamberlin, A. J., Lafferty, K. D., Kuris, A. M., Jocque, M., Hopkins, S., Adams, G., Buck, J. C., Lund, A. J., Garcia-vedreene, A. E., Fiorenza, E., Rohr, J. R., Allan, F., Webster, B., Rabone, M., Webster, J. P., Bandagny, L., Ndione, R., …De Leo, G. A. (2019). Precision mapping of snail habitat provides a powerful indicator of human schistosomiasis transmission. Proceedings of the National Academy of Sciences, 116(46), 23182-23191. https://doi.org/10.1073/pnas.1903698116

Recently, the World Health Organization recognized that efforts to interrupt schistosomiasis transmission through mass drug administration have been ineffective in some regions; one of their new recommended strategies for global schistosomiasis contr... Read More about Precision mapping of snail habitat provides a powerful indicator of human schistosomiasis transmission.

Evaluation of DNA extraction methods on individual helminth egg and larval stages for whole genome sequencing (2019)
Journal Article
Doyle, S. R., Sankaranarayan, G., Berger, D., Jimenez Castro, P. D., Collins, J. B., Crellen, T., Duque-Correa, M. A., Ellis, P., Jaleta, T. G., Laing, R., Maitland, K., McCarthy, C., Moundai, T., Softley, B., Thiele, E., Tchindebet Ouakou, P., Tushabe, J. V., Webster, J. P., Weiss, A. J., Lok, J., …Holroyd, N. (2019). Evaluation of DNA extraction methods on individual helminth egg and larval stages for whole genome sequencing. https://doi.org/10.1101/616672

Rodents of Senegal and their role as intermediate hosts of Hydatigera spp. (Cestoda: Taeniidae) (2018)
Journal Article
Catalano, S., Bâ, K., Diouf, N., Léger, E., Verocai, G., & Webster, J. P. (2018). Rodents of Senegal and their role as intermediate hosts of Hydatigera spp. (Cestoda: Taeniidae). Parasitology, 146(3), 299-304. https://doi.org/10.1017/S0031182018001427

Hydatigera (Cestoda: Taeniidae) is a recently resurrected genus including species seldom investigated in sub-Saharan Africa. We surveyed wild small mammal populations in the areas of Richard Toll and Lake Guiers, Senegal, with the objective to evalua... Read More about Rodents of Senegal and their role as intermediate hosts of Hydatigera spp. (Cestoda: Taeniidae).

Opportunities and challenges for modelling epidemiological and evolutionary dynamics in a multihost, multiparasite system: Zoonotic hybrid schistosomiasis in West Africa (2018)
Journal Article
Borlase, A., Webster, J. P., & Rudge, J. W. (2018). Opportunities and challenges for modelling epidemiological and evolutionary dynamics in a multihost, multiparasite system: Zoonotic hybrid schistosomiasis in West Africa. Evolutionary Applications, 11(4), 501-515. https://doi.org/10.1111/eva.12529

Multihost multiparasite systems are evolutionarily and ecologically dynamic, which presents substantial trans‐disciplinary challenges for elucidating their epidemiology and designing appropriate control. Evidence for hybridizations and introgressions... Read More about Opportunities and challenges for modelling epidemiological and evolutionary dynamics in a multihost, multiparasite system: Zoonotic hybrid schistosomiasis in West Africa.

The effects of subcurative praziquantel treatment on life-history traits and trade-offs in drug-resistant Schistosoma mansoni (2018)
Journal Article
Viana, M., Faust, C. L., Haydon, D. T., Webster, J. P., & Lamberton, P. H. L. (2018). The effects of subcurative praziquantel treatment on life-history traits and trade-offs in drug-resistant Schistosoma mansoni. Evolutionary Applications, 11(3), 488-500. https://doi.org/10.1111/eva.12558

Natural selection acts on all organisms, including parasites, to maximize reproductive fitness. Drug resistance traits are often associated with life-history costs in the absence of treatment. Schistosomiasis control programmes rely on mass drug admi... Read More about The effects of subcurative praziquantel treatment on life-history traits and trade-offs in drug-resistant Schistosoma mansoni.

Rodents as natural hosts of zoonotic Schistosoma species and hybrids: an epidemiological and evolutionary perspective from West Africa (2018)
Journal Article
Catalano, S., Sène, M., Diouf, N. D., Fall, C. B., Borlase, A., Léger, E., Bâ, K., & Webster, J. P. (2018). Rodents as natural hosts of zoonotic Schistosoma species and hybrids: an epidemiological and evolutionary perspective from West Africa. Journal of Infectious Diseases, 218(3), 429-433. https://doi.org/10.1093/infdis/jiy029

The complex multi-host disease dynamics of schistosomiasis and Schistosoma spp., including the emergence of zoonotic parasite hybrids, remain largely unexplored in West Africa. We elucidated the role of wild small mammals as reservoir for zoonotic Sc... Read More about Rodents as natural hosts of zoonotic Schistosoma species and hybrids: an epidemiological and evolutionary perspective from West Africa.

Phenotypic and genotypic monitoring of Schistosoma mansoni in Tanzanian schoolchildren five years into a preventative chemotherapy national control programme (2017)
Journal Article
Gower, C. M., Gehre, F., Marques, S. R., Lamberton, P. H. L., Lwambo, N. J., & Webster, J. P. (2017). Phenotypic and genotypic monitoring of Schistosoma mansoni in Tanzanian schoolchildren five years into a preventative chemotherapy national control programme. https://doi.org/10.1186/s13071-017-2533-6

We conducted combined in vitro PZQ efficacy testing with population genetic analyses of S. mansoni collected from children from two schools in 2010, five years after the introduction of a National Control Programme. Children at one school had receive... Read More about Phenotypic and genotypic monitoring of Schistosoma mansoni in Tanzanian schoolchildren five years into a preventative chemotherapy national control programme.

Who acquires infection from whom and how? Disentangling multi-host and multi-mode transmission dynamics in the 'elimination' era (2017)
Journal Article
Webster, J. P., Borlase, A. M., & Rudge, J. W. (2017). Who acquires infection from whom and how? Disentangling multi-host and multi-mode transmission dynamics in the 'elimination' era. Philosophical Transactions of the Royal Society B: Biological Sciences, 372(1719), https://doi.org/10.1098/rstb.2016.0091

Multi-host infectious agents challenge our abilities to understand, predict and manage disease dynamics. Within this, many infectious agents are also able to use, simultaneously or sequentially, multiple modes of transmission. Furthermore, the relati... Read More about Who acquires infection from whom and how? Disentangling multi-host and multi-mode transmission dynamics in the 'elimination' era.

Preliminary genetic evidence of two different populations of Opisthorchis viverrini in Lao PDR (2017)
Journal Article
Pitaksakulrat, O., Kiatsopit, N., Laoprom, N., Webster, B. L., Webster, J. P., Lamberton, P. H. L., Laha, T., Andrews, R. H., Petney, T. N., Blair, D., Carlton, E. J., Spear, R. C., & Sithithaworn, P. (2017). Preliminary genetic evidence of two different populations of Opisthorchis viverrini in Lao PDR. Parasitology Research, 116(4), 1247-1256. https://doi.org/10.1007/s00436-017-5401-6

One Health – an Ecological and Evolutionary Framework for tackling Neglected Zoonotic Diseases (2016)
Journal Article
Webster, J. P., Gower, C. M., Knowles, S. C. L., & Fenton, A. (2016). One Health – an Ecological and Evolutionary Framework for tackling Neglected Zoonotic Diseases. Evolutionary Applications, 9(2), 313-333. https://doi.org/10.1111/eva.12341

Understanding the complex population biology and transmission ecology of multihost parasites has been declared as one of the major challenges of biomedical sciences for the 21st century and the Neglected Zoonotic Diseases (NZDs) are perhaps the most... Read More about One Health – an Ecological and Evolutionary Framework for tackling Neglected Zoonotic Diseases.

Multi-parallel qPCR provides increased sensitivity and diagnostic breadth for gastrointestinal parasites of humans: field-based inferences on the impact of mass deworming (2016)
Journal Article
Easton, A. V., Oliveira, R. G., O'Connell, E. M., Kepha, S., Mwandawiro, C. S., Njenga, S. M., Kihara, J. H., Mwatele, C., Odiere, M. R., Brooker, S. J., Webster, J. P., Anderson, R. M., & Nutman, T. B. (2016). Multi-parallel qPCR provides increased sensitivity and diagnostic breadth for gastrointestinal parasites of humans: field-based inferences on the impact of mass deworming. https://doi.org/10.1186/s13071-016-1314-y

Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites
Journal Article
Platt, R. N., McDew-White, M., Le Clec'H, W., Chevalier, F. D., Allan, F., Emery, A. M., Garba, A., Hamidou, A. A., Ame, S. M., Webster, J. P., Rollinson, D., Webster, B. L., & Anderson, T. J. C. (in press). Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites. Molecular Biology and Evolution, 36(10), 2127-2142. https://doi.org/10.1093/molbev/msz154

Introgression among parasite species has the potential to transfer traits of biomedical importance across species boundaries. The parasitic blood fluke Schistosoma haematobium causes urogenital schistosomiasis in humans across sub-Saharan Africa. Hyb... Read More about Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites.