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Outputs (15)

Defining the genes required for survival of Mycobacterium bovis in the bovine host offers novel insights into the genetic basis of survival of pathogenic mycobacteria (2022)
Journal Article
Gibson, A. J., Stiens, J., Passmore, I. J., Faulkner, V., Miculob, J., Willcocks, S., Coad, M., Berg, S., Werling, D., Wren, B. W., Nobeli, I., Villarreal-Ramos, B., & Kendall, S. L. (2022). Defining the genes required for survival of Mycobacterium bovis in the bovine host offers novel insights into the genetic basis of survival of pathogenic mycobacteria. mBio, https://doi.org/10.1128/mbio.00672-22

Tuberculosis has severe impacts in both humans and animals. Understanding the genetic basis of survival of both Mycobacterium tuberculosis, the human adapted species, and Mycobacterium bovis, the animal adapted species is crucial to deciphering the b... Read More about Defining the genes required for survival of Mycobacterium bovis in the bovine host offers novel insights into the genetic basis of survival of pathogenic mycobacteria.

Probing differences in gene essentiality between the human and animal adapted (2021)
Journal Article
Gibson, A. J., Passmore, I. J., Faulkner, V., Xia, D., Nobeli, I., Stiens, J., Clarke, T. G., Sobkowiak, B., Willcocks, S., Werling, D., Villarreal-Ramos, B., Wren, B. W., & Kendall, S. L. (2021). Probing differences in gene essentiality between the human and animal adapted. Frontiers in Veterinary Science,

Members of the Mycobacterium tuberculosis complex (MTBC) show distinct host adaptations, preferences and phenotypes despite being >99% identical at the nucleic acid level. Previous studies have explored gene expression changes between the members, ho... Read More about Probing differences in gene essentiality between the human and animal adapted.

Molecular basis for DarT ADP-ribosylation of a DNA base (2021)
Journal Article
Schuller, M., Butler, R., Ariza, A., Tromans-Coia, C., Jankevicius, G., Claridge, T., Kendall, S., Goh, S., Stewart, G., & Ahel, I. (2021). Molecular basis for DarT ADP-ribosylation of a DNA base. Nature, https://doi.org/10.1038/s41586-021-03825-4

ADP-ribosyltransferases (ARTs) utilise NAD+ to catalyse substrate ADP-ribosylation, thereby regulating cellular pathways or contributing to toxin-mediated pathogenicity of bacteria. Reversible ADP-ribosylation has traditionally been considered a prot... Read More about Molecular basis for DarT ADP-ribosylation of a DNA base.

Re-sensitization of Mycobacterium smegmatis to Rifampicin Using CRISPR Interference Demonstrates Its Utility for the Study of Non-essential Drug Resistance Traits (2021)
Journal Article
Kendall, S. L., Faulkner, V., Cox, A. A., Goh, S., van Bohemen, A., Gibson, A. J., Liebster, O., Wren, B. W., & Willcocks, S. (in press). Re-sensitization of Mycobacterium smegmatis to Rifampicin Using CRISPR Interference Demonstrates Its Utility for the Study of Non-essential Drug Resistance Traits. Frontiers in Microbiology, 11, https://doi.org/10.3389/fmicb.2020.619427

A greater understanding of the genes involved in antibiotic resistance in Mycobacterium tuberculosis (Mtb) is necessary for the design of improved therapies. Clustered regularly interspaced short palindromic repeat interference (CRISPRi) has been pre... Read More about Re-sensitization of Mycobacterium smegmatis to Rifampicin Using CRISPR Interference Demonstrates Its Utility for the Study of Non-essential Drug Resistance Traits.

Isolation and Potential for Transmission of Mycobacterium bovis at Human–livestock–wildlife Interface of the Serengeti Ecosystem, Northern Tanzania (2017)
Journal Article
Katale, B. Z., Mbugi, E. V., Siame, K. K., Keyyu, J. D., Kendall, S., Kazwala, R. R., Dockrell, H. M., Fyumagwa, R., Michel, A. L., Rweyemamu, M., Streicher, E. M., Warren, R. M., Van Helden, P., & Matee, M. I. (2017). Isolation and Potential for Transmission of Mycobacterium bovis at Human–livestock–wildlife Interface of the Serengeti Ecosystem, Northern Tanzania. Transboundary and Emerging Diseases, 64(3), 815-825. https://doi.org/10.1111/tbed.12445

Mapping of Mycobacterium tuberculosis Complex Genetic Diversity Profiles in Tanzania and Other African Countries (2016)
Journal Article
Mbugi, E. V., Katale, B. Z., Streicher, E. M., Keyyu, J. D., Kendall, S. L., Dockrell, H. M., Michel, A. L., Rweyemamu, M. M., Warren, R. M., Matee, M. I., van Helden, P. D., Couvin, D., & Rastogi, N. (2016). Mapping of Mycobacterium tuberculosis Complex Genetic Diversity Profiles in Tanzania and Other African Countries. PLoS ONE, 11(5), https://doi.org/10.1371/journal.pone.0154571

The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis (2016)
Journal Article
Ho, N. A. T., Dawes, S. S., Crowe, A. M., Casabon, I., Gao, C., Kendall, S. L., Baker, E. N., Eltis, L. D., & Lott, J. S. (2016). The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis. Journal of Biological Chemistry, 291(14), 7256-7266. https://doi.org/10.1074/jbc.M115.707760

Cholesterol can be a major carbon source for Mycobacterium tuberculosis during infection, both at an early stage in the macrophage phagosome and later within the necrotic granuloma. KstR is a highly conserved TetR family transcriptional repressor tha... Read More about The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.

Species diversity of non-tuberculous mycobacteria isolated from humans, livestock and wildlife in the Serengeti ecosystem, Tanzania (2014)
Journal Article
Katale, B. Z., Mbugi, E. V., Botha, L., Keyyu, J. D., Kendall, S. L., Dockrell, H. M., Michel, A. L., Kazwala, R. R., Rweyemamu, M. M., van Helden, P., & Matee, M. I. (2014). Species diversity of non-tuberculous mycobacteria isolated from humans, livestock and wildlife in the Serengeti ecosystem, Tanzania. BMC Infectious Diseases, 14, https://doi.org/10.1186/s12879-014-0616-y

Prevalence and risk factors for infection of bovine tuberculosis in indigenous cattle in the Serengeti ecosystem, Tanzania (2013)
Journal Article
Katale, B. Z., Mbugi, E. V., Karimuribo, E. D., Keyyu, J. D., Kendall, S., Kibiki, G. S., Godfrey-Faussett, P., Michel, A. L., Kazwala, R. R., van Helden, P., & Matee, M. I. (2013). Prevalence and risk factors for infection of bovine tuberculosis in indigenous cattle in the Serengeti ecosystem, Tanzania. BMC Veterinary Research, 9(9), 1746-6148. https://doi.org/10.1186/1746-6148-9-267

The mycobacterial two-component regulatory systems (2005)
Book Chapter
Kendall, S. (2005). The mycobacterial two-component regulatory systems. . Horizon Bioscience

Rison SCG, Kendall SL, Movahedzadeh F, Stoker NG.. In: Parish T, editor. Mycobacterium Molecular Microbiology.