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Outputs (452)

Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites
Journal Article
Platt, R. N., McDew-White, M., Le Clec'H, W., Chevalier, F. D., Allan, F., Emery, A. M., Garba, A., Hamidou, A. A., Ame, S. M., Webster, J. P., Rollinson, D., Webster, B. L., & Anderson, T. J. C. (in press). Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites. Molecular Biology and Evolution, 36(10), 2127-2142. https://doi.org/10.1093/molbev/msz154

Introgression among parasite species has the potential to transfer traits of biomedical importance across species boundaries. The parasitic blood fluke Schistosoma haematobium causes urogenital schistosomiasis in humans across sub-Saharan Africa. Hyb... Read More about Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites.

Mycoplasma hyopneumoniae evades phagocytic uptake by porcine alveolar macrophages in vitro
Journal Article
Deeney, A. S., Maglennon, G. A., Chapat, L., Crussard, S., Jolivet, E., & Rycroft, A. N. (in press). Mycoplasma hyopneumoniae evades phagocytic uptake by porcine alveolar macrophages in vitro. Veterinary Research, 50(51), https://doi.org/10.1186/s13567-019-0667-6

Mycoplasma hyopneumoniae, the agent of porcine enzootic pneumonia (EP), is able to persist in the lung tissue and evade destruction by the host for several weeks. To understand the mechanism of pathogen survival, phagocytic uptake of M. hyopneumoniae... Read More about Mycoplasma hyopneumoniae evades phagocytic uptake by porcine alveolar macrophages in vitro.

Dietary vitamin D improves performance and bone mineralisation, but increases parasite replication and compromises gut health in Eimeria infected broilers
Journal Article
Sakkas, P., Oikeh, I., Blake, D. P., Smith, S., & Kyriazakis, I. (in press). Dietary vitamin D improves performance and bone mineralisation, but increases parasite replication and compromises gut health in Eimeria infected broilers. British Journal of Nutrition, https://doi.org/10.1017/S0007114519001375

Coccidial infections may reduce fat soluble vitamin status and bone mineralisation in broiler chickens. We hypothesised that broilers infected with Eimeria maxima would benefit from increased dietary supplementation with vitamin D (vitD) or with 25-O... Read More about Dietary vitamin D improves performance and bone mineralisation, but increases parasite replication and compromises gut health in Eimeria infected broilers.

High prevalence of USA300 among clinical isolates of methicillin-resistant Staphylococcus aureus on St. Kitts and Nevis, West Indies
Journal Article
Guardabassi, L., Moodley, A., Williams, A., Stegger, M., Damborg, P., Halliday-Simmonds, I., & Butaye, P. R. (in press). High prevalence of USA300 among clinical isolates of methicillin-resistant Staphylococcus aureus on St. Kitts and Nevis, West Indies. Frontiers in Microbiology, 10, 1123. https://doi.org/10.3389/fmicb.2019.01123

Limited information is available on antimicrobial susceptibility and clonal distribution of Staphylococcus aureus in the Caribbean region. The aims of this study were to determine the prevalence of antimicrobial resistance among S. aureus isolates an... Read More about High prevalence of USA300 among clinical isolates of methicillin-resistant Staphylococcus aureus on St. Kitts and Nevis, West Indies.

The Genetics of Life and Death: Virus-Host Interactions Underpinning Resistance to African Swine Fever, a Viral Hemorrhagic Disease
Journal Article
Netherton, C. L., Connell, S., Benfield, C. T. O., & Dixon, L. K. (in press). The Genetics of Life and Death: Virus-Host Interactions Underpinning Resistance to African Swine Fever, a Viral Hemorrhagic Disease. Frontiers in Genetics, https://doi.org/10.3389/fgene.2019.00402

Pathogen transmission from wildlife hosts to genetically distinct species is a major driver of disease emergence. African swine fever virus (ASFV) persists in sub-Saharan Africa through a sylvatic cycle between warthogs and soft ticks that infest the... Read More about The Genetics of Life and Death: Virus-Host Interactions Underpinning Resistance to African Swine Fever, a Viral Hemorrhagic Disease.

The Role and Welfare of Cart Donkeys Used in Waste Management in Karachi, Pakistan
Journal Article
Shah, S. Z. A., Nawaz, Z., Nawaz, S., Carder, G., Ali, M., Soomro, N., & Compston, P. C. (in press). The Role and Welfare of Cart Donkeys Used in Waste Management in Karachi, Pakistan. Animals, 9(4), https://doi.org/10.3390/ani9040159

Equine ownership is a common income-generating strategy in Pakistan. In Karachi, donkey carts are used to transport building materials, commercial produce and garbage. This study aimed to articulate the role and welfare of donkeys used in waste manag... Read More about The Role and Welfare of Cart Donkeys Used in Waste Management in Karachi, Pakistan.

Canine Respiratory Coronavirus, Bovine Coronavirus, and Human Coronavirus OC43: Receptors and Attachment Factors
Journal Article
Szczepanski, A., Owczarek, K., Bzowska, M., Gula, K., Drebot, I., Ochman, M., Maksym, B., Rajfur, Z., Mitchell, J. A., & Pyrc, K. (in press). Canine Respiratory Coronavirus, Bovine Coronavirus, and Human Coronavirus OC43: Receptors and Attachment Factors. Viruses, 11(4), 328. https://doi.org/10.3390/v11040328

Despite high similarity of canine respiratory coronavirus (CRCoV), bovine coronavirus, (BCoV) and human coronavirus OC43 (HCoV-OC43), these viruses differ in species specificity. For years it was believed that they share receptor specificity, utilizi... Read More about Canine Respiratory Coronavirus, Bovine Coronavirus, and Human Coronavirus OC43: Receptors and Attachment Factors.

Antimicrobial Resistance Diversity Suggestive of Distinct Salmonella Typhimurium Sources or Selective Pressures in Food-Production Animals
Journal Article
Mellor, K. C., Petrovska, L., Thomson, N. R., Harris, K., Reid, S. W. J., & Mather, A. E. (in press). Antimicrobial Resistance Diversity Suggestive of Distinct Salmonella Typhimurium Sources or Selective Pressures in Food-Production Animals. Frontiers in Microbiology, 10, https://doi.org/10.3389/fmicb.2019.00708

Salmonella enterica subsp. enterica serovar Typhimurium is a common cause of enterocolitis in humans globally, with multidrug resistant (MDR) strains posing an enhanced threat. S. Typhimurium is also a pathogen in food-production animals, and these p... Read More about Antimicrobial Resistance Diversity Suggestive of Distinct Salmonella Typhimurium Sources or Selective Pressures in Food-Production Animals.

Strategies for tackling Taenia solium taeniosis/cysticercosis: A systematic review and comparison of transmission models, including an assessment of the wider Taeniidae family transmission models
Journal Article
Dixon, M. A., Braae, U. C., Winskill, P., Walker, M., Devleesschauwer, B., Gabriël, S., & Basáñez, M.-G. (in press). Strategies for tackling Taenia solium taeniosis/cysticercosis: A systematic review and comparison of transmission models, including an assessment of the wider Taeniidae family transmission models. PLoS Neglected Tropical Diseases, 13, e0007301. https://doi.org/10.1371/journal.pntd.0007301

Structure–Activity Study, Characterization, and Mechanism of Action of an Antimicrobial Peptoid D2 and Its d- and l-Peptide Analogues
Journal Article
Greco, I., Hansen, J. E., Jana, B., Molchanova, N., Oddo, A., Thulstrup, P. W., Damborg, P., Guardabassi, L., & Hansen, P. R. (in press). Structure–Activity Study, Characterization, and Mechanism of Action of an Antimicrobial Peptoid D2 and Its d- and l-Peptide Analogues. Molecules, 24(6), 1121. https://doi.org/10.3390/molecules24061121

Methicillin-resistant Staphylococcus pseudintermedius (MRSP) constitutes an emerging health problem for companion animals in veterinary medicine. Therefore, discovery of novel antimicrobial agents for treatment of Staphylococcus-associated canine inf... Read More about Structure–Activity Study, Characterization, and Mechanism of Action of an Antimicrobial Peptoid D2 and Its d- and l-Peptide Analogues.

International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats
Journal Article
Weese, J. S., Blondeau, J., Boothe, D., Guardabassi, L., Gumley, N., Papich, M., Jessen, L. R., Lappin, M., Rankin, S., Westropp, J. L., & Sykes, J. (in press). International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats. https://doi.org/10.1016/j.tvjl.2019.02.008

Urinary tract disease is a common clinical presentation in dogs and cats, and a common reason for antimicrobial prescription. This document is a revision and expansion on the 2011 Antimicrobial Use Guidelines for Treatment of Urinary Tract Disease in... Read More about International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats.

Biological Characterization of Pasteurella multocida present in the Saiga Population
Journal Article
Orynbayev, M., Sultankulova, K., Sansyzbay, A., Rystayeva, R., Shorayeva, K., Namet, A., Fereidouni, S., Ilgekbayeva, G., Barakbayev, K., Kopeyev, S., & Kock, R. A. (in press). Biological Characterization of Pasteurella multocida present in the Saiga Population. BMC Microbiology, 19(37), https://doi.org/10.1186/s12866-019-1407-9

This study provides biochemical and molecular genetic characteristics of P. multocida isolated from dead saigas in 1988, 2010–2015 on the territory of the Republic of Kazakhstan.

Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections
Journal Article
Greco, I., Emborg, A. P., Jana, B., Molchanova, N., Oddo, A., Damborg, P., Guardabassi, L., & Hansen, P. R. (in press). Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections. https://doi.org/10.1038/s41598-019-39042-3

Integumentary infections like pyoderma represent the main reason for antimicrobial prescription in dogs. Staphylococcus pseudintermedius and Pseudomonas aeruginosa are frequently identified in these infections, and both bacteria are challenging to co... Read More about Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections.

Comparative micro-epidemiology of pathogenic avian influenza virus outbreaks in a wild bird population
Journal Article
Hill, S. C., Hansen, R., Watson, S., Coward, V., Russell, C., Cooper, J., Essen, S., Everest, H., Parag, K. V., Fiddaman, S., Reid, S., Lewis, N. S., Brookes, S. M., Smith, A. L., Sheldon, B., Perrins, C. M., Brown, I. H., & Pybus, O. G. (in press). Comparative micro-epidemiology of pathogenic avian influenza virus outbreaks in a wild bird population. Philosophical Transactions of the Royal Society B: Biological Sciences, 374(1775), https://doi.org/10.1098/rstb.2018.0259

Understanding the epidemiological dynamics of highly pathogenic avian influenza virus (HPAIV) in wild birds is crucial for guiding effective surveillance and control measures. The spread of H5 HPAIV has been well characterized over large geographical... Read More about Comparative micro-epidemiology of pathogenic avian influenza virus outbreaks in a wild bird population.

Diagnosis and drug resistance of human soil-transmitted helminth infections: A public health perspective
Journal Article
Mutombo, P. N., Man, N. W. Y., Nejsum, P., Ricketson, R., Gordon, C. A., Robertson, G., Clements, A. C. A., Chacon-Fonseca, N., Nissapatorn, V., Webster, J. P., & McLaws, M.-L. Diagnosis and drug resistance of human soil-transmitted helminth infections: A public health perspective. https://doi.org/10.1016/bs.apar.2019.02.004

Soil-transmitted helminth (STH) infections represent a major public health problem globally, particularly among socio-economically disadvantaged populations. Detection of STH infections is often challenging, requiring a combination of diagnostic tech... Read More about Diagnosis and drug resistance of human soil-transmitted helminth infections: A public health perspective.

Phenotypic and genetic variation in the response of chickens to Eimeria tenella induced coccidiosis
Journal Article
Boulton, K., Nolan, M. J., Wu, Z. G., Psifidi, A., Riggio, V., Harman, K., Bishop, S. C., Kaiser, P., Abrahamsen, M. S., Hawken, R., Watson, K. A., Tomley, F. M., Blake, D. P., & Hume, D. A. (in press). Phenotypic and genetic variation in the response of chickens to Eimeria tenella induced coccidiosis. Genetics Selection Evolution, 50(63), https://doi.org/10.1186/s12711-018-0433-7