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Outputs (998)

Accuracy of the TurfTrax Racing Data System for determination of equine speed and position
Journal Article
Spence, A. J., Tan, H., & Wilson, A. M. Accuracy of the TurfTrax Racing Data System for determination of equine speed and position. Equine Veterinary Journal, 40(7), 680-683. https://doi.org/10.2746/042516408X330338

Reasons for performing study: The speed and position data collected by TurfTrax Racing Data Limited during UK Thoroughbred racing have potential to benefit equine science and welfare. The size (the 2006 data set alone consists of 30,932 individual ho... Read More about Accuracy of the TurfTrax Racing Data System for determination of equine speed and position.

The effect of early training and the adaptation and conditioning of skeletal tissues
Journal Article
Smith, R. K. W., & Goodship, A. E. The effect of early training and the adaptation and conditioning of skeletal tissues. https://doi.org/10.1016/j.cveq.2007.11.005

Horses as equine athletes must be conditioned and trained to optimize the whole animal for the particular type of athletic activity. An extremely high proportion of all injuries in the equine athlete in general, and in the racehorse in particular, ar... Read More about The effect of early training and the adaptation and conditioning of skeletal tissues.

Mesenchymal stem cell therapy for equine tendinopathy
Journal Article
Smith, R. K. W. Mesenchymal stem cell therapy for equine tendinopathy. Disability and Rehabilitation, 30(20-22), 1752-1758. https://doi.org/10.1080/09638280701788241

Optimal management of tendon overuse injuries in equine and human athletes should avoid the formation of excessive scar tissue, regenerate normal tendon matrix, and reduce re-injury rates. We hypothesized that the implantation of marrow-derived strom... Read More about Mesenchymal stem cell therapy for equine tendinopathy.

Principles of stem cell therapy in the horse - the science behind the technology
Journal Article
Smith, R. K. W. Principles of stem cell therapy in the horse - the science behind the technology

Tendon and ligament overstrain injuries in the horse are appropriate diseases to consider for stem cell therapy because normal fibrous repair results in reduced functionality, typified by poorer performance and a high rate of re-injury. Exogenously a... Read More about Principles of stem cell therapy in the horse - the science behind the technology.

Stem cell therapy for tendon and ligament injuries in the horse - technique and outcome
Journal Article
Smith, R. K. W. Stem cell therapy for tendon and ligament injuries in the horse - technique and outcome

The technique involves the collection of bone marrow from the sternum in the standing sedated horse, followed by isolation and expansion of the nucleated adherent cell population (containing the MSCs) in the laboratory. After approximately 2-3 weeks,... Read More about Stem cell therapy for tendon and ligament injuries in the horse - technique and outcome.

Diagnostic ultrasound of the limb joints, muscle and bone in horses
Journal Article
Smith, M., & Smith, R. K. W. Diagnostic ultrasound of the limb joints, muscle and bone in horses. In Practice, 30(3), 152-159

DIAGNOSTIC ultrasonography for the musculoskeletal system in the horse was first used in the early 1980s. Initial applications were directed towards the diagnosis of flexor tendon and ligament injuries in the distal limb, but this modality is now com... Read More about Diagnostic ultrasound of the limb joints, muscle and bone in horses.

Identifying the cellular basis for reimplantation failure in repair of the rotator cuff
Journal Article
Simon, D. W. N., Clarkin, C. E., Das-Gupta, V., Rawlinson, S. C. F., Emery, R. J., & Pitsillides, A. A. Identifying the cellular basis for reimplantation failure in repair of the rotator cuff. https://doi.org/10.1302/0301-620x.90b5.20013

We examined cultured osteoblasts derived from paired samples from the greater tuberosity and acromion from eight patients with large chronic tears of the rotator cuff. We found that osteoblasts from the tuberosity had no apparent response to mechanic... Read More about Identifying the cellular basis for reimplantation failure in repair of the rotator cuff.

Investigating the pathology of Emery-Dreifuss muscular dystrophy
Journal Article
Brown, S. C., Piercy, R. J., Muntoni, F., & Sewry, C. A. Investigating the pathology of Emery-Dreifuss muscular dystrophy. Biochemical Society Transactions, 36(Pt 6), 1335-1338. https://doi.org/10.1042/bst0361335

EDMD (Emery-Dreifuss muscular dystrophy) is caused by mutations in either the gene encoding for lamin A/C (LMNA) located at 1q21.2-q21.3 of emerin (EMD) located at Xq28. Autosomal dominant EDMD caused by LMNA mutations is more common than the X-linke... Read More about Investigating the pathology of Emery-Dreifuss muscular dystrophy.

Take-off and landing kinetics of a free-ranging gliding mammal, the Malayan colugo (Galeopterus variegatus)
Journal Article
Byrnes, G., Lim, N. T. L., & Spence, A. J. Take-off and landing kinetics of a free-ranging gliding mammal, the Malayan colugo (Galeopterus variegatus). https://doi.org/10.1098/rspb.2007.1684

Arboreal animals negotiate a highly three-dimensional world that is discontinuous on many spatial scales. As the scale of substrate discontinuity increases, many arboreal animals rely on leaping or gliding locomotion between distant supports. In orde... Read More about Take-off and landing kinetics of a free-ranging gliding mammal, the Malayan colugo (Galeopterus variegatus).

Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts
Journal Article
Chen, Y. L., Leask, A., Abraham, D. J., Pala, D., Xu, S. W., Khan, K., Liu, S. X., Carter, D. E., Wilcox-Adelman, S., Goetinck, P., Denton, C. P., Black, C. M., Pitsillides, A. A., Sarraf, C. E., & Eastwood, M. Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts. Arthritis and Rheumatism, 58(2), 577-585. https://doi.org/10.1002/art.23146

Objective. To investigate the contribution of heparan sulfate proteoglycan and Ras/MEK/ERK to the overexpression of profibrotic proteins and the enhanced contractile ability of dermal fibroblasts from patients with systemic sclerosis (SSc; scleroderm... Read More about Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts.

Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells
Journal Article
Clarkin, C. E., Emery, R. J., Pitsillides, A. A., & Wheeler-Jones, C. P. D. Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells. Journal of Cellular Physiology, 214(2), 537-544. https://doi.org/10.1002/jcp.21234

Communication between endothelial and bone cells is crucial for controlling vascular supply during bone growth, remodeling, and repair but the molecular mechanisms coordinating this intercellular crosstalk remain ill-defined. We have used primary hum... Read More about Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells.