Cohort Profile: The 'Bristol Cats Study' (BCS)-a birth cohort of kittens owned by UK households
(2017)
Journal Article
Murray, J. K., Casey, R. A., Gale, E., Buffington, C. A. T., Roberts, C., Kinsman, R. H., & Gruffydd-Jones, T. J. (2017). Cohort Profile: The 'Bristol Cats Study' (BCS)-a birth cohort of kittens owned by UK households. International Journal of Epidemiology, 46(6), 1749+. https://doi.org/10.1093/ije/dyx066
Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats (2017)
Journal Article
Doodnaught, G. M., Monteiro, B. P., Benito, J., Edge, D., Beaudry, F., Pelligand, L., & Steagall, P. (2017). Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats. PLoS ONE, 12(4), w0176443. https://doi.org/10.1371/journal.pone.0176443The aim of this study was to describe the joint pharmacokinetic-pharmacodynamic model and evaluate thermal antinociception of a high-concentration formulation of buprenorphine (Simbadol™) in cats.
Owner perception of focal seizures in canine epilepsy (2017)
Journal Article
Packer, R. M. A., Lucas, R., & Volk, H. A. (2017). Owner perception of focal seizures in canine epilepsy. Veterinary Record, 180(6), 150. https://doi.org/10.1136/vr.104099
Serum biomarkers of oxidative stress in dogs with idiopathic inflammatory bowel disease (2017)
Journal Article
Rubio, C. P., Martínez-Subiela, S., Hernández-Ruiz, J., Tvarijonaviciute, A., Cerón, J. J., & Allenspach, K. (2017). Serum biomarkers of oxidative stress in dogs with idiopathic inflammatory bowel disease. https://doi.org/10.1016/j.tvjl.2017.02.003
The pharmacological regulation of cellular mitophagy (2017)
Journal Article
Georgakopoulos, N. D., Wells, G., & Campanella, M. (2017). The pharmacological regulation of cellular mitophagy. Nature Chemical Biology, 13, 136-146. https://doi.org/10.1038/nchembio.2287
What is the true in vitro potency of oxytetracycline for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida? (2017)
Journal Article
Dorey, L., Hobson, S., & Lees, P. (2017). What is the true in vitro potency of oxytetracycline for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida?. Journal of Veterinary Pharmacology and Therapeutics, 40(5), 517-529. https://doi.org/10.1111/jvp.12386The pharmacodynamics of oxytetracycline was determined for pig respiratory tract pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida. Indices of potency were determined for the following: (i) two matrices, broth and pig serum; (ii) f... Read More about What is the true in vitro potency of oxytetracycline for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida?.
Comparison of standardised versus non-standardised methods for testing the in vitro potency of oxytetracycline against mannheimia haemolytica and pasteurella multocida (2016)
Journal Article
Lees, P., Illambas, J., Pelligand, L., & Toutain, P. L. (2016). Comparison of standardised versus non-standardised methods for testing the in vitro potency of oxytetracycline against mannheimia haemolytica and pasteurella multocida. https://doi.org/10.1016/j.tvjl.2016.11.006
An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity (2016)
Journal Article
Holder, A., Mella, S., Palmer, D. B., Aspinall, R., & Catchpole, B. (2016). An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity. PLoS ONE, 11, e0165968. https://doi.org/10.1371/journal.pone.0165968The age associated decline in immune function is preceded in mammals by a reduction in thymic output. Furthermore, there is increasing evidence of a link between immune competence and lifespan. One approach to determining thymic output is to quantify... Read More about An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity.
Single Nucleotide Polymorphisms in Major histocompatibility class II haplotypes are associated with potential resistance to inflammatory bowel disease in German shepherd dogs (2016)
Journal Article
Peiravan, A., Allenspach, K., Boag, A. M., Soutter, F., Holder, A. L., Catchpole, B., …Procoli, F. (2016). Single Nucleotide Polymorphisms in Major histocompatibility class II haplotypes are associated with potential resistance to inflammatory bowel disease in German shepherd dogs. Veterinary Immunology and Immunopathology, 182, 101-105. https://doi.org/10.1016/j.vetimm.2016.10.012
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease (2016)
Journal Article
Deas, E., Cremades, N., Angelova, P. R., Ludtmann, M. H. R., Yao, Z., Chen, S., …Abramov, A. Y. (2016). Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease. https://doi.org/10.1089/ars.2015.6343Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown. In this study, we describe how aggregati... Read More about Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease.
MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR (2015)
Journal Article
Singh, Y., Garden, O. A., Lang, F., & Cobb, B. S. (2015). MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR. Journal of Immunology, 195(12), 5667-5677. https://doi.org/10.4049/jimmunol.1401875CD4(+) regulatory T cells (Tregs) are essential for controlling immune responses and preventing autoimmunity. Their development requires regulation of gene expression by microRNAs (miRNAs). To understand miRNA function in Treg development, we searche... Read More about MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR.
Breed differences in development of anti-insulin antibodies in diabetic dogs and investigation of the role of dog leukocyte antigen (DLA) genes (2015)
Journal Article
Holder, A. L., Kennedy, L. J., Ollier, W. E. R., & Catchpole, B. (2015). Breed differences in development of anti-insulin antibodies in diabetic dogs and investigation of the role of dog leukocyte antigen (DLA) genes. Veterinary Immunology and Immunopathology, 167(3-4), 130-8. https://doi.org/10.1016/j.vetimm.2015.07.014Administration of insulin for treatment of diabetes mellitus in dogs can stimulate an immune response, with a proportion of animals developing anti-insulin antibodies (AIA). For an IgG antibody response to occur, this would require B cell presentatio... Read More about Breed differences in development of anti-insulin antibodies in diabetic dogs and investigation of the role of dog leukocyte antigen (DLA) genes.
Comparison of gabapentin versus topiramate on clinically affected dogs with Chiari-like malformation and syringomyelia (2015)
Journal Article
Plessas, I. N., Volk, H. A., Rusbridge, C., Vanhaesebrouck, A. E., & Jeffery, N. D. (2015). Comparison of gabapentin versus topiramate on clinically affected dogs with Chiari-like malformation and syringomyelia. Veterinary Record, 177(11), 288-288. https://doi.org/10.1136/vr.103234To date there is no evidence-based data for efficacious treatment of neuropathic pain in dogs with Chiari-like malformation (CM) and syringomyelia (SM). The objective of this prospective cross-over study was to compare the effect of gabapentin versus... Read More about Comparison of gabapentin versus topiramate on clinically affected dogs with Chiari-like malformation and syringomyelia.
Comparison of computed tomographic and pathologic findings in 17 dogs with primary adrenal neoplasia (2015)
Journal Article
Gregori, T., Mantis, P., Benigni, L., Priestnall, S. L., & Lamb, C. R. (2015). Comparison of computed tomographic and pathologic findings in 17 dogs with primary adrenal neoplasia. https://doi.org/10.1111/vru.12209
Shh regulates chick Ebf1 gene expression in somite development (2015)
Journal Article
El-Magd, M. A., Allen, S. P., McGonnell, I. M., Mansour, A. A., Otto, A., & Patel, K. (2015). Shh regulates chick Ebf1 gene expression in somite development. Gene, 554(1), 87-95. https://doi.org/10.1016/j.gene.2014.10.028The chick early B-cell factor 1 (cEbf1) is a member of EBF family of helix loop helix transcription factors. Recently, we have proved that cEbf1 expression in feather is regulated by Shh. It is therefore possible that the somitic expression of cEbf1... Read More about Shh regulates chick Ebf1 gene expression in somite development.
Effect of a photoperiodic green light program during incubation on embryo development and hatch process (2015)
Journal Article
Tong, Q., McGonnell, I. M., Romanini, C. E., Bergoug, H., Roulston, N., Berckmans, D., …Demmers, T. G. M. (2015). Effect of a photoperiodic green light program during incubation on embryo development and hatch process
Searching for "monogenic diabetes" in dogs using a candidate gene approach (2014)
Journal Article
Short, A. D., Holder, A. L., Rothwell, S., Massey, J., Scholey, R., Kennedy, L. J., …Ollier, W. E. R. (2014). Searching for "monogenic diabetes" in dogs using a candidate gene approach. Canine Genetics and Epidemiology, 1(8), https://doi.org/10.1186/2052-6687-1-8
Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves (2013)
Journal Article
Brentnall, C., Cheng, Z. R., McKellar, Q. A., & Lees, P. (2013). Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves. Journal of Veterinary Pharmacology and Therapeutics, 36(4), 320-328. https://doi.org/10.1111/jvp.12000A tissue cage model of inflammation in calves was used to determine the pharmacokinetic and pharmacodynamic properties of individual carprofen enantiomers, following the administration of the racemate. RS(±) carprofen was administered subcutaneously... Read More about Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves.
A comprehensive pathological survey of duodenal biopsies from dogs with diet-responsive chronic enteropathy (2013)
Journal Article
Walker, D. J., Knuchel-Takano, A., McCutchan, A., Chang, Y. M., Downes, C., Miller, S., …Garden, O. A. (2013). A comprehensive pathological survey of duodenal biopsies from dogs with diet-responsive chronic enteropathy. Journal of Veterinary Internal Medicine, 27(4), 862-874. https://doi.org/10.1111/jvim.12093
Equine Embryonic Stem Cell-Derived Tenocytes are Insensitive to a Combination of Inflammatory Cytokines and Have Distinct Molecular Responses Compared to Primary Tenocytes (0000)
Journal Article
Smith, E. J., Beaumont, R. E., Dudhia, J., & Guest, D. J. (0000). Equine Embryonic Stem Cell-Derived Tenocytes are Insensitive to a Combination of Inflammatory Cytokines and Have Distinct Molecular Responses Compared to Primary Tenocytes. Stem Cell Reviews and Reports, https://doi.org/10.1007/s12015-024-10693-8Tissue fibrosis following tendon injury is a major clinical problem due to the increased risk of re-injury and limited treatment options; however, its mechanism remains unclear. Evidence suggests that insufficient resolution of inflammation contribut... Read More about Equine Embryonic Stem Cell-Derived Tenocytes are Insensitive to a Combination of Inflammatory Cytokines and Have Distinct Molecular Responses Compared to Primary Tenocytes.
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