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Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

Deas, E; Cremades, N; Angelova, P R; Ludtmann, M H R; Yao, Z; Chen, S; Horrocks, M H; Banushi, B; Little, D; Devine, M J; Gissen, P; Klenerman, D; Dobson, C M; Wood, N W; Gandhi, S; Abramov, A Y

Authors

E Deas

N Cremades

P R Angelova

M H R Ludtmann

Z Yao

S Chen

M H Horrocks

B Banushi

D Little

M J Devine

P Gissen

D Klenerman

C M Dobson

N W Wood

S Gandhi

A Y Abramov



Abstract

Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown. In this study, we describe how aggregation of alpha-synuclein (α-S) from its monomeric form to its soluble oligomeric state results in aberrant free radical production and neuronal toxicity.

Citation

Deas, E., Cremades, N., Angelova, P. R., Ludtmann, M. H. R., Yao, Z., Chen, S., …Abramov, A. Y. (2016). Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease. https://doi.org/10.1089/ars.2015.6343

Journal Article Type Article
Acceptance Date Nov 10, 2015
Publication Date Feb 23, 2016
Deposit Date Jun 28, 2018
Publicly Available Date Jun 28, 2018
Journal Antioxidants & Redox Signaling
Peer Reviewed Peer Reviewed
Volume 24
Issue 7
Pages 376-91
DOI https://doi.org/10.1089/ars.2015.6343
Public URL https://rvc-repository.worktribe.com/output/1397543

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