Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

Deas, E; Cremades, N; Angelova, P R; Ludtmann, M H R; Yao, Z; Chen, S; Horrocks, M H; Banushi, B; Little, D; Devine, M J; Gissen, P; Klenerman, D; Dobson, C M; Wood, N W; Gandhi, S; Abramov, A Y

Abstract

Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown. In this study, we describe how aggregation of alpha-synuclein (α-S) from its monomeric form to its soluble oligomeric state results in aberrant free radical production and neuronal toxicity.

Citation

Deas, E., Cremades, N., Angelova, P. R., Ludtmann, M. H. R., Yao, Z., Chen, S., Horrocks, M. H., Banushi, B., Little, D., Devine, M. J., Gissen, P., Klenerman, D., Dobson, C. M., Wood, N. W., Gandhi, S., & Abramov, A. Y. (2016). Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease. https://doi.org/10.1089/ars.2015.6343

• Journal Article Type: Article
• Acceptance Date: Nov 10, 2015
• Publication Date: Feb 23, 2016
• Deposit Date: Jun 28, 2018
• Publicly Available Date: Jun 28, 2018
• Journal: Antioxidants & Redox Signaling
• Peer Reviewed: Peer Reviewed
• Volume: 24
• Issue: 7
• Pages: 376-91
• DOI: https://doi.org/10.1089/ars.2015.6343
• Public URL: https://rvc-repository.worktribe.com/output/1397543