Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats

Doodnaught, G M; Monteiro, B P; Benito, J; Edge, D; Beaudry, F; Pelligand, L; Steagall, P

Abstract

The aim of this study was to describe the joint pharmacokinetic-pharmacodynamic model and evaluate thermal antinociception of a high-concentration formulation of buprenorphine (Simbadol™) in cats.

Citation

Doodnaught, G. M., Monteiro, B. P., Benito, J., Edge, D., Beaudry, F., Pelligand, L., & Steagall, P. (2017). Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats. PLoS ONE, 12(4), w0176443. https://doi.org/10.1371/journal.pone.0176443

• Journal Article Type: Article
• Acceptance Date: Apr 10, 2017
• Publication Date: Apr 26, 2017
• Deposit Date: Nov 10, 2017
• Publicly Available Date: Nov 10, 2017
• Journal: PLoS ONE
• Electronic ISSN: 1932-6203
• Publisher: Public Library of Science
• Peer Reviewed: Peer Reviewed
• Volume: 12
• Issue: 4
• Pages: w0176443
• DOI: https://doi.org/10.1371/journal.pone.0176443
• Public URL: https://rvc-repository.worktribe.com/output/1392189