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A Functional Single-Nucleotide Polymorphism Upstream of the Collagen Type III Gene Is Associated with Catastrophic Fracture Risk in Thoroughbred Horses (2023)
Journal Article
Lago, E. P., Baird, A., Blott, S. C., Mcphail, R. E., Ross, A. C., Durward-Akhurst, S. A., & Guest, D. J. (2023). A Functional Single-Nucleotide Polymorphism Upstream of the Collagen Type III Gene Is Associated with Catastrophic Fracture Risk in Thoroughbred Horses. Animals, 14(1), 116. https://doi.org/10.3390/ani14010116

Fractures caused by bone overloading are a leading cause of euthanasia in Thoroughbred racehorses. The risk of fatal fracture has been shown to be influenced by both environmental and genetic factors but, to date, no specific genetic mechanisms unde... Read More about A Functional Single-Nucleotide Polymorphism Upstream of the Collagen Type III Gene Is Associated with Catastrophic Fracture Risk in Thoroughbred Horses.

PROSPECTIVE EVALUATION OF PLATELET FUNCTION AND FIBRINOLYSIS IN 20 DOGS WITH TRAUMA (2023)
Journal Article
Cortellini, S., Chan, D., McBride, D., & Birkbeck, R. (in press). PROSPECTIVE EVALUATION OF PLATELET FUNCTION AND FIBRINOLYSIS IN 20 DOGS WITH TRAUMA. Journal of Veterinary Emergency and Critical Care, https://doi.org/10.1111/vec.13356

Objectives: To determine platelet function and fibrinolysis in dogs following trauma using multiple electrical impedance aggregometry and a modified thromboelastographic technique. To determine if the severity of trauma, as assessed by the Animal Tr... Read More about PROSPECTIVE EVALUATION OF PLATELET FUNCTION AND FIBRINOLYSIS IN 20 DOGS WITH TRAUMA.

BEVA primary care clinical guidelines: Diagnosis and management of equine pituitary pars intermedia dysfunction (2023)
Journal Article
Menzies-Gow, N., Knowles, E., & Hart, N. (in press). BEVA primary care clinical guidelines: Diagnosis and management of equine pituitary pars intermedia dysfunction. Equine Veterinary Journal, https://doi.org/10.1111/evj.14009

Background: Pituitary pars intermedia dysfunction (PPID) is a prevalent, age-related chronic disorder in equids. Diagnosis of PPID can be challenging because of its broad spectrum of clinical presentations and disparate published diagnostic criteria,... Read More about BEVA primary care clinical guidelines: Diagnosis and management of equine pituitary pars intermedia dysfunction.

Mechanosignalling pathways that regulate endothelial barrier function (2023)
Journal Article
McQueen, A., & Warboys, C. M. (2023). Mechanosignalling pathways that regulate endothelial barrier function. Current Opinion in Cell Biology, 84, 102213. https://doi.org/10.1016/j.ceb.2023.102213

Blood vessels are lined by a single layer of endothelial cells that provide a barrier between circulating plasma and the underlying tissue. Permeability of endothelial cells is tightly regulated, and increased permeability is associated with a number... Read More about Mechanosignalling pathways that regulate endothelial barrier function.

Exogenous interleukin-1 beta stimulation regulates equine tenocyte function and gene expression in three-dimensional culture which can be rescued by pharmacological inhibition of interleukin 1 receptor, but not nuclear factor kappa B, signaling (2023)
Journal Article
Beaumont, R. E., Smith, E. J., Zhou, L., Marr, N., Thorpe, C. T., & Guest, D. J. (in press). Exogenous interleukin-1 beta stimulation regulates equine tenocyte function and gene expression in three-dimensional culture which can be rescued by pharmacological inhibition of interleukin 1 receptor, but not nuclear factor kappa B, signaling. Molecular and Cellular Biochemistry, https://doi.org/10.1007/s11010-023-04779-z

Metformin and empagliflozin combination modulate macrophage inflammatory gene expression (2023)
Journal Article
Arefin, A., & Gage, M. C. (2023). Metformin and empagliflozin combination modulate macrophage inflammatory gene expression. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms24054785

Type-2 Diabetes Mellitus is a complex, chronic illness characterized by persistent high blood glucose levels. Patients can be described anti diabetes drugs as single agents or in combination depending on the severity of their condition. Metformin and... Read More about Metformin and empagliflozin combination modulate macrophage inflammatory gene expression.

A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis (2023)
Journal Article
Elliott, J. (2023). A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis. Equine Veterinary Journal, https://doi.org/10.1111/evj.13933

Equine laminitis has both fascinated and frustrated veterinary researchers and clinicians for many years. The recognition that many ponies suffering from pasture associated laminitis have an insulin dysregulated phenotype (endocrinopathic laminitis,... Read More about A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis.

Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway (2023)
Journal Article
Rickman, M., Ghim, M., Pang, K., von Huelsen Rocha, A. C., Drudi, E. M., Sureda-Vives, M., …Warboys, C. M. (in press). Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway. Journal of Cell Science, https://doi.org/10.1242/jcs.260449

Multidirectional or disturbed flow promotes endothelial dysfunction and is associated with early atherogenesis. Here we investigated the role of Wnt signalling in flow-mediated endothelial dysfunction. The expression of Frizzled-4 was higher in cultu... Read More about Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway.

Shear-mediated ALK5 expression regulates endothelial activation (2023)
Journal Article
Pang, K. T., Ghim, M., Sarathchandra, P., Warboys, C. M., Yacoub, M. H., Chester, A. H., & Weinberg, P. D. (2023). Shear-mediated ALK5 expression regulates endothelial activation. Biochemical and Biophysical Research Communications, 642, 90-96. https://doi.org/10.1016/j.bbrc.2022.12.058

Calcific aortic valve disease affects the aortic side of the valve, exposed to low magnitude multidirectional (“disturbed) blood flow, more than it affects the ventricular side, exposed to high magnitude uniaxial flow. Overt disease is preceded by en... Read More about Shear-mediated ALK5 expression regulates endothelial activation.

Tonsillar carcinoma in dogs: Treatment outcome and potential prognostic factors in 123 cases (2023)
Journal Article
Treggiari, E., Pellin, M. A., Romanelli, G., Maresca, G., Gramer, I., Yale, A. D., …Berlato, D. (in press). Tonsillar carcinoma in dogs: Treatment outcome and potential prognostic factors in 123 cases. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16623

Hypothesis/Objectives: Assess treatment outcome and potential prognostic factors in a population of dogs with cytological or histopathological diagnosis of tonsillar carcinoma. Animals: A total of 123 client-owned dogs with diagnosis of tonsillar... Read More about Tonsillar carcinoma in dogs: Treatment outcome and potential prognostic factors in 123 cases.