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Equine Embryonic Stem Cell-Derived Tenocytes are Insensitive to a Combination of Inflammatory Cytokines and Have Distinct Molecular Responses Compared to Primary Tenocytes (0000)
Journal Article
Smith, E. J., Beaumont, R. E., Dudhia, J., & Guest, D. J. (0000). Equine Embryonic Stem Cell-Derived Tenocytes are Insensitive to a Combination of Inflammatory Cytokines and Have Distinct Molecular Responses Compared to Primary Tenocytes. Stem Cell Reviews and Reports, https://doi.org/10.1007/s12015-024-10693-8

Tissue fibrosis following tendon injury is a major clinical problem due to the increased risk of re-injury and limited treatment options; however, its mechanism remains unclear. Evidence suggests that insufficient resolution of inflammation contribut... Read More about Equine Embryonic Stem Cell-Derived Tenocytes are Insensitive to a Combination of Inflammatory Cytokines and Have Distinct Molecular Responses Compared to Primary Tenocytes.

LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation
Journal Article
Ludtmann, M. H. R., Kostic, M., Horne, A., Gandhi, S., Sekler, I., & Abramov, A. Y. (in press). LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation. https://doi.org/10.1038/s41419-019-1469-5

Variants of leucine-rich repeat kinase 2 (lrrk2) are associated with an increased risk in developing Parkinson’s disease (PD). Mitochondrial dysfunction and specifically mitochondrial Ca2+ handling has been linked to the pathogenesis of PD. Here we d... Read More about LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation.

Laminitis in horses
Journal Article
Menzies-Gow, N. J. (in press). Laminitis in horses. Veterinary Record, 183(16), 505-506. https://doi.org/10.1136/inp.k4485

Laminitis is a common and painful condition of adult equids that often results in permanent lameness or euthanasia. In recent years, our knowledge of the condition has developed and this article discusses the current understanding of laminitis and ap... Read More about Laminitis in horses.

Anesthesia Case of the Month
Journal Article
Robinson, R. L., & Borer-Weir, K. E. Anesthesia Case of the Month. Journal of the American Veterinary Medical Association, 250(2), 169-172

The Companion Dog as a Model for the Longevity Dividend
Journal Article
Creevy, K. E., Austad, S. N., Hoffman, J. M., Promislow, D. E. L., & O'Neill, D. G. The Companion Dog as a Model for the Longevity Dividend. https://doi.org/10.1101/cshperspect.a026633

The companion dog is the most phenotypically diverse species on the planet. This enormous variability between breeds extends not only to morphology and behavior but also to longevity and the disorders that affect dogs. There are remarkable overlaps a... Read More about The Companion Dog as a Model for the Longevity Dividend.