Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias
(2021)
Journal Article
Vavouraki, N., Tomkins, J. E., Kara, E., Houlden, H., Hardy, J., Tindall, M. J., …Manzoni, C. (2021). Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias. iScience, 102484. https://doi.org/10.1016/j.isci.2021.102484
Machine-learning based prediction of Cushing’s syndrome in dogs attending UK primary-care veterinary practice (2021)
Journal Article
Schofield, I., Brodbelt, D. C., Kennedy, N., Niessen, S. J. M., Church, D. B., Geddes, R. F., & O’Neill, D. G. (2021). Machine-learning based prediction of Cushing’s syndrome in dogs attending UK primary-care veterinary practice. Scientific Reports, 11(1), https://doi.org/10.1038/s41598-021-88440-zCushing’s syndrome is an endocrine disease in dogs that negatively impacts upon the quality-of-life of affected animals. Cushing’s syndrome can be a challenging diagnosis to confirm, therefore new methods to aid diagnosis are warranted. Four machine-... Read More about Machine-learning based prediction of Cushing’s syndrome in dogs attending UK primary-care veterinary practice.
Predictive Simulations of Musculoskeletal Function and Jumping Performance in a Generalized Bird (2021)
Journal Article
Bishop, P., Falisse, A., De Groote, F., & Hutchinson, J. (in press). Predictive Simulations of Musculoskeletal Function and Jumping Performance in a Generalized Bird. Integrative Organismal Biology, https://doi.org/10.1093/iob/obab006Jumping is a common, but demanding, behavior that many animals employ during everyday activity. In contrast to jump-specialists such as anurans and some primates, jumping biomechanics and the factors that influence performance remains little studied... Read More about Predictive Simulations of Musculoskeletal Function and Jumping Performance in a Generalized Bird.
A Retrospective Case Study into the Effect of Hoof Lesions on the Lying Behaviour of Holstein–Friesian in a Loose-Housed System (2021)
Journal Article
Ji, K., Booth, R., & Blackie, N. (in press). A Retrospective Case Study into the Effect of Hoof Lesions on the Lying Behaviour of Holstein–Friesian in a Loose-Housed System. Animals, https://doi.org/10.3390/ani11041120The association between hoof lesions and lying behaviour was assessed on a Holstein–Friesian dairy farm in England. Twenty-nine cows were included in the study. Cows with claw horn disruption lesions (CHDL, n = 8), soft tissue lesions (STL, n = 6), a... Read More about A Retrospective Case Study into the Effect of Hoof Lesions on the Lying Behaviour of Holstein–Friesian in a Loose-Housed System.
Comparison of the Ability of High and Low Virulence Strains of noncytopathic Bovine Viral Diarrhoea Virus-1 to Modulate Expression of Interferon Tau Stimulated Genes in Bovine Endometrium (2021)
Journal Article
Cheng, Z., Wang, K., Thomas, C., Zhang, S., & Wathes, D. C. (2021). Comparison of the Ability of High and Low Virulence Strains of noncytopathic Bovine Viral Diarrhoea Virus-1 to Modulate Expression of Interferon Tau Stimulated Genes in Bovine Endometrium. Frontiers in Veterinary Science,Bovine Viral Diarrhoea virus (BVDV) is a pestivirus with a single-stranded, positive sense RNA genome. It is endemic in many cattle populations, causing major economic losses in part due to reduced fertility. BVDV exhibits great genetic diversity an... Read More about Comparison of the Ability of High and Low Virulence Strains of noncytopathic Bovine Viral Diarrhoea Virus-1 to Modulate Expression of Interferon Tau Stimulated Genes in Bovine Endometrium.
Computational modelling of muscle fibre operating ranges in the hindlimb of a small ground bird (Eudromia elegans), with implications for modelling locomotion in extinct species (2021)
Journal Article
Hutchinson, J. R., Allen, V. R., Bishop, P. J., Michel, K. B., Falisse, A., De Groote, F., & Cuff, A. R. (in press). Computational modelling of muscle fibre operating ranges in the hindlimb of a small ground bird (Eudromia elegans), with implications for modelling locomotion in extinct species. PLoS Computational Biology, 17(4), e1008843. https://doi.org/10.1371/journal.pcbi.1008843
Analysis of Cryptosporidium spp. from clinical samples by matrix‐assisted laser desorption/ionisation time‐of‐flight mass spectrometry (2021)
Journal Article
Gathercole, R., Tranfield, E., Xia, D., Perez‐Cordon, G., Robinson, G., Timofte, D., …Chalmers, R. (in press). Analysis of Cryptosporidium spp. from clinical samples by matrix‐assisted laser desorption/ionisation time‐of‐flight mass spectrometry. Journal of Applied Microbiology, https://doi.org/10.1111/jam.15077
Demographic History, Adaptation, and NRAP Convergent Evolution at Amino Acid Residue 100 in the World Northernmost Cattle from Siberia (2021)
Journal Article
Buggiotti, L., Yurchenko, A. A., Yudin, N. S., Jagt, C. J. V., Vorobieva, N. V., Kusliy, M. F., …Larkin, D. M. (2021). Demographic History, Adaptation, and NRAP Convergent Evolution at Amino Acid Residue 100 in the World Northernmost Cattle from Siberia. Molecular Biology and Evolution,Native cattle breeds represent an important cultural heritage. They are a reservoir of genetic variation useful for properly responding to agriculture needs in the light of ongoing climate changes. Evolutionary processes that occur in response to ext... Read More about Demographic History, Adaptation, and NRAP Convergent Evolution at Amino Acid Residue 100 in the World Northernmost Cattle from Siberia.
Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction (2021)
Journal Article
Menzies-Gow, N., Hague, N., & Durham, A. (2021). Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction. Veterinary Record, https://doi.org/10.1002/vetr.142Background: Equine pituitary pars intermedia dysfunction (PPID) is treated with daily pergolide therapy. Owner compliance and its effect on PPID control has not been previously investigated. Methods: Clinical records were searched to identify the sa... Read More about Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction.
Frequency, breed predisposition and demographic risk factors for overweight status in dogs in the UK (2021)
Journal Article
Pegram, C., Raffan, E., White, E., Ashworth, A., Brodbelt, D., Church, D., & O'Neill, D. (2021). Frequency, breed predisposition and demographic risk factors for overweight status in dogs in the UK. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13325Objectives: To evaluate the prevalence and risk factors for overweight status in dogs under primary veterinary care in the UK. Methods: A retrospective study design was used to estimate the one-year (2016) period prevalence of overweight status. The... Read More about Frequency, breed predisposition and demographic risk factors for overweight status in dogs in the UK.
Musculoskeletal modelling of the Nile crocodile (Crocodylus niloticus) hindlimb: Effects of limb posture on leverage during terrestrial locomotion (2021)
Journal Article
Wiseman, A. L. A., Bishop, P. J., Demuth, O. E., Cuff, A. R., Michel, K. B., & Hutchinson, J. R. (in press). Musculoskeletal modelling of the Nile crocodile (Crocodylus niloticus) hindlimb: Effects of limb posture on leverage during terrestrial locomotion. Journal of Anatomy, https://doi.org/10.1111/joa.13431
The evolution of pelvic limb muscle moment arms in bird-line archosaurs (2021)
Journal Article
Allen, V. R., Kilbourne, B. M., & Hutchinson, J. R. (2021). The evolution of pelvic limb muscle moment arms in bird-line archosaurs. Science Advances, 7(12), eabe2778. https://doi.org/10.1126/sciadv.abe2778
Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease (2021)
Journal Article
Russell, C., Minnis, C. J., Townsend, S., Petschnigg, J., Tinelli, E., Bähler, J., …Mole, S. E. (2021). Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease. Scientific Reports,Juvenile CLN3 disease is a recessively inherited paediatric neurodegenerative disorder, with most patients homozygous for a 1-kb intragenic deletion in CLN3. The btn1 gene is the Schizosaccharomyces pombe orthologue of CLN3. Here, we have extended th... Read More about Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease.
Dog breeds and body conformations with predisposition to osteosarcoma in the UK: a case-control study (2021)
Journal Article
Edmunds, G. L., Smalley, M. J., Beck, S., Errington, R. J., Gould, S., Winter, H., …O’Neill, D. G. (2021). Dog breeds and body conformations with predisposition to osteosarcoma in the UK: a case-control study. Canine Medicine and Genetics, 8(1), https://doi.org/10.1186/s40575-021-00100-7
Early life exposure to air pollution impacts neuronal and glial cell function leading to impaired neurodevelopment (2021)
Journal Article
Morris, R. H., Counsell, S. J., McGonnell, I. M., & Thornton, C. (in press). Early life exposure to air pollution impacts neuronal and glial cell function leading to impaired neurodevelopment. BioEssays, 2000288. https://doi.org/10.1002/bies.202000288The World Health Organisation recently listed air pollution as the most significant threat to human health. Air pollution comprises particulate matter (PM), metals, black carbon and gases such as ozone (O3), nitrogen dioxide (NO2) and carbon monoxide... Read More about Early life exposure to air pollution impacts neuronal and glial cell function leading to impaired neurodevelopment.
Exploring the functional morphology of the Gorilla shoulder through musculoskeletal modelling (2021)
Journal Article
van Beesel, J., Hutchinson, J. R., Hublin, J., & Melillo, S. M. (in press). Exploring the functional morphology of the Gorilla shoulder through musculoskeletal modelling. Journal of Anatomy, https://doi.org/10.1111/joa.13412
A Grand Challenge for Animal Science: Multiple Goals – Convergent and Divergent (2021)
Journal Article
Nicol, C. (2021). A Grand Challenge for Animal Science: Multiple Goals – Convergent and Divergent. Frontiers in Animal Science, 2, https://doi.org/10.3389/fanim.2021.640503People want safe, affordable, high quality animal-derived foods, produced in ways that protect rural livelihoods and cultures and which are derived from animals that lived healthy and happy lives. These aspirations must be set alongside the overarchi... Read More about A Grand Challenge for Animal Science: Multiple Goals – Convergent and Divergent.
Sensitivity of the Natriuretic Peptide/cGMP System to Hyperammonaemia in Rat C6 Glioma Cells and GPNT Brain Endothelial Cells (2021)
Journal Article
Regan, J., Mirczuk, S., Scudder, C., Stacey, E., Khan, S., Powles, T., …Fowkes, R. (2021). Sensitivity of the Natriuretic Peptide/cGMP System to Hyperammonaemia in Rat C6 Glioma Cells and GPNT Brain Endothelial Cells. Cells, https://doi.org/10.3390/cells10020398C-type natriuretic peptide (CNP) is the major natriuretic peptide of the central nervous system and acts via its selective guanylyl cyclase-B (GC-B) receptor to regulate cGMP production in neurons, astrocytes and endothelial cells. CNP is implicated... Read More about Sensitivity of the Natriuretic Peptide/cGMP System to Hyperammonaemia in Rat C6 Glioma Cells and GPNT Brain Endothelial Cells.
Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time? (2021)
Journal Article
Ho, K., Fleseriu, M., Kaiser, U., Salvatori, R., Brue, T., Lopes, M. B., …Melmed, S. (2021). Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time?. Journal of the Endocrine Society, 5(3), https://doi.org/10.1210/jendso/bvaa205The WHO Classification of Endocrine Tumours designates pituitary neoplasms as adenomas. A proposed nomenclature change to pituitary neuroendocrine tumors (PitNETs) has been met with concern by some stakeholder groups. The Pituitary Society coordinate... Read More about Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time?.
Systematic analysis reveals that colony housing aligns gait profiles and strengthens link between 1 histological and micro-CT bone markers in rat models of osteoarthritis 2 Short running title: Colony housing strengthens osteoarthritis research (2021)
Journal Article
Chang, Y., Menges, S., Westhof, A., Kleinschmidt-Doerr, K., Brenneis, C., Pitsillides, A. A., & Chang, Y. (in press). Systematic analysis reveals that colony housing aligns gait profiles and strengthens link between 1 histological and micro-CT bone markers in rat models of osteoarthritis 2 Short running title: Colony housing strengthens osteoarthritis research. FASEB Journal, -. https://doi.org/10.1096/fj.202002009R
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