Predictors of laminitis development in a cohort of non-laminitic ponies (2021)
Journal Article
Knowles, E., Elliott, J., Harris, P., Chang, R., & Menzies-Gow, N. (2021). Predictors of laminitis development in a cohort of non-laminitic ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.31_13492

Background: Quantifying the risk of laminitis development requires improvement. Objectives: To identify the most useful physical examination, metabolic and management factors to predict future laminitis development in client-owned, non-laminitic pon... Read More about Predictors of laminitis development in a cohort of non-laminitic ponies.

Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells (2021)
Journal Article
Nazish, I., Arber, C., Piers, T. M., Warner, T. T., Hardy, J. A., Lewis, P. A., …Bandopadhyay, R. (2021). Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells. Neurochemistry International, 147, 105070. https://doi.org/10.1016/j.neuint.2021.105070

Connecting the Neurobiology of Developmental Brain Injury: Neuronal Arborisation as a Regulator of Dysfunction and Potential Therapeutic Target (2021)
Journal Article
Goikolea-Vives, A., & Stolp, H. B. (in press). Connecting the Neurobiology of Developmental Brain Injury: Neuronal Arborisation as a Regulator of Dysfunction and Potential Therapeutic Target. International Journal of Molecular Sciences, 22(15), 8220. https://doi.org/10.3390/ijms22158220

Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor (2021)
Journal Article
Pang, K. T., Ghim, M., Liu, C., Tay, H. M., Fhu, C. W., Chia, R. N., …Wang, X. (2021). Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor. Frontiers in Cell and Developmental Biology, 9, https://doi.org/10.3389/fcell.2021.706143

Elevated serum concentrations of leucine-rich α-2-glycoprotein (LRG1) have been reported in patients with inflammatory, autoimmune, and cardiovascular diseases. This study aims to investigate the role of LRG1 in endothelial activation. LRG1 in endoth... Read More about Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor.

Genotyping and Whole-Genome Resequencing of Welsh Sheep Breeds Reveal Candidate Genes and Variants for Adaptation to Local Environment and Socioeconomic Traits (2021)
Journal Article
Sweet-Jones, J., Lenis, V. P., Yurchenko, A. A., Yudin, N. S., Swain, M., & Larkin, D. M. (2021). Genotyping and Whole-Genome Resequencing of Welsh Sheep Breeds Reveal Candidate Genes and Variants for Adaptation to Local Environment and Socioeconomic Traits. Frontiers in Genetics, 12, https://doi.org/10.3389/fgene.2021.612492

Background: Advances in genetic tools applied to livestock breeding has prompted research into the previously neglected breeds adapted to harsh local environments. One such group is the Welsh mountain sheep breeds, which can be farmed at altitudes of... Read More about Genotyping and Whole-Genome Resequencing of Welsh Sheep Breeds Reveal Candidate Genes and Variants for Adaptation to Local Environment and Socioeconomic Traits.

Associations between behaviour and health outcomes in conventional and slow-growing breeds of broiler chicken (2021)
Journal Article
Abeyesinghe, S., Abeyesinghe, S., Chancellor, N., Hernandez Moore, D., Chang, Y., Pearce, J., …Nicol, C. (2021). Associations between behaviour and health outcomes in conventional and slow-growing breeds of broiler chicken. animal, 15(7), Article 100261. https://doi.org/10.1016/j.animal.2021.100261

Broiler chickens are prone to a range of complex health and welfare issues. To support informed selection of welfare traits whilst minimising impact on production efficiency and to address a major gap in understanding, we systematically explored asso... Read More about Associations between behaviour and health outcomes in conventional and slow-growing breeds of broiler chicken.

Global transcriptomic profiles of circulating leucocytes in early lactation cows with clinical or subclinical mastitis (2021)
Journal Article
Cheng, Z., Buggiotti, L., Salavati, M., Marchitelli, C., Palma-Vera, S., Wylie, A., …GplusE Consortium. (in press). Global transcriptomic profiles of circulating leucocytes in early lactation cows with clinical or subclinical mastitis. Molecular Biology Reports,

Bovine mastitis is an inflammatory disease of the mammary gland, which is classified as subclinical or clinical. Circulating neutrophils are recruited to the udder to help combat infection. We compared the transcriptomic profiles in circulating leuko... Read More about Global transcriptomic profiles of circulating leucocytes in early lactation cows with clinical or subclinical mastitis.

An ethical framework for the use of horses in competitive sport: theory and function (2021)
Journal Article
Campbell, M. (2021). An ethical framework for the use of horses in competitive sport: theory and function. Animals, https://doi.org/10.3390/ani11061725

Growing ethical concern about equestrian sport is reflected in publications by regulatory authorities, animal charities, and the lay press; and in government debate and social media. However, attempts by regulators and stakeholders to address ethica... Read More about An ethical framework for the use of horses in competitive sport: theory and function.

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein (2021)
Journal Article
Kara, E., Crimi, A., Wiedmer, A., Emmenegger, M., Manzoni, C., Bandres-Ciga, S., …Aguzzi, A. (2021). An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein. Cell Reports, 35(10), 109189. https://doi.org/10.1016/j.celrep.2021.109189

The evolutionary biomechanics of locomotor function in giant land animals (2021)
Journal Article
Hutchinson, J. (2021). The evolutionary biomechanics of locomotor function in giant land animals. Journal of Experimental Biology, https://doi.org/10.1242/jeb.217463

Giant land vertebrates have evolved more than 30 times, notably in dinosaurs and mammals. The evolutionary and biomechanical perspectives considered here unify data from extant and extinct species, assessing current theory regarding how the locomotor... Read More about The evolutionary biomechanics of locomotor function in giant land animals.

Intra-operative Raman spectroscopy and ex vivo Raman mapping for assessment of cartilage degradation (2021)
Journal Article
Gaifulina, R., Nunn, A. D. G., Draper, E. R. C., Strachan, R. K., Blake, N., Firth, S., …6ap, U. K. (2021). Intra-operative Raman spectroscopy and ex vivo Raman mapping for assessment of cartilage degradation. Applied Spectroscopy, https://doi.org/10.1016/j.clispe.2021.100012

The development of a label-free, non-destructive and safe analytical method such as Raman spectroscopy for assessing cartilage degradation is highly desirable. Compared to non-optical imaging modalities, Raman mapping offers a more sensitive means of... Read More about Intra-operative Raman spectroscopy and ex vivo Raman mapping for assessment of cartilage degradation.

The pen is milder than the blade: Identification marking mice using ink on the tail appears more humane than ear-punching even with local anaesthetic (2021)
Journal Article
Burn, C., Mazlan, N., Chancellor, N., & Wells, D. (2021). The pen is milder than the blade: Identification marking mice using ink on the tail appears more humane than ear-punching even with local anaesthetic. Animals, 11, https://doi.org/10.3390/ani11061664

Identification marking mice commonly involves ear-punching with or without anaesthetic, or tail-marking with ink. To identify which is most humane, we marked male BALB/c mice using ear-punching (EP), ear-punching with anaesthetic EMLATM cream (EP+A),... Read More about The pen is milder than the blade: Identification marking mice using ink on the tail appears more humane than ear-punching even with local anaesthetic.

Wild American mink (Neovison vison) may pose a COVID-19 threat (2021)
Journal Article
Diez Leon, M., Harrington, L., Díez-León, M., Gómez, A., Harrington, A., Macdonald, D., …Roy, S. (2021). Wild American mink (Neovison vison) may pose a COVID-19 threat. Frontiers in Ecology and the Environment, https://doi.org/10.1002/fee.2344

Limb myology and muscle architecture of the Indian rhinoceros Rhinoceros unicornis and the white rhinoceros Ceratotherium simum (Mammalia: Rhinocerotidae) (2021)
Journal Article
Hutchinson, J., Etienne, C., & Houssaye, A. (2021). Limb myology and muscle architecture of the Indian rhinoceros Rhinoceros unicornis and the white rhinoceros Ceratotherium simum (Mammalia: Rhinocerotidae). PeerJ, https://doi.org/10.7717/peerj.11314

Land mammals support and move their body using their musculoskeletal system. Their musculature usually presents varying adaptations with body mass or mode of locomotion. Rhinocerotidae is an interesting clade in this regard, as they are heavy anima... Read More about Limb myology and muscle architecture of the Indian rhinoceros Rhinoceros unicornis and the white rhinoceros Ceratotherium simum (Mammalia: Rhinocerotidae).

Future research priorities in canine epilepsy: viewpoints of owners, general practice veterinarians and neurology specialists (2021)
Journal Article
Jones, G., Volk, H., & Packer, R. (in press). Future research priorities in canine epilepsy: viewpoints of owners, general practice veterinarians and neurology specialists. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16144

Background: Epilepsy is the most common chronic neurological disease in dogs that impacts the quality of life (QoL) of affected dogs and their owners. Canine epilepsy research is expanding internationally, but where best to focus limited research tim... Read More about Future research priorities in canine epilepsy: viewpoints of owners, general practice veterinarians and neurology specialists.

Proportion and risk factors for death by euthanasia in dogs in the UK (2021)
Journal Article
O'Neill, D., Pegram, C., Gray, C., Packer, R. M., Richards, Y., Church, D. B., …O’Neill, D. G. (2021). Proportion and risk factors for death by euthanasia in dogs in the UK. International Journal of Advanced Scientific Engineering and Technological Research, https://doi.org/10.1038/s41598-021-88342-0

Objectives: To report proportional euthanasia or unassisted death, as well as the demographic and clinical factors associated with euthanasia, in dogs under primary veterinary care in the UK. Methods: A cohort study design to estimate proportional... Read More about Proportion and risk factors for death by euthanasia in dogs in the UK.

The zebrafish cardiac endothelial cell – roles in development and regeneration (2021)
Journal Article
Pellet-Many, C., Lowe, V., & Wisniewski, L. (2021). The zebrafish cardiac endothelial cell – roles in development and regeneration. Journal of Cardiovascular Development and Disease,

In zebrafish, the spatiotemporal development of the vascular system is well described due to its stereotypical nature. However, the cellular and molecular mechanisms orchestrating post embryonic vascular development, the maintenance of vascular homeo... Read More about The zebrafish cardiac endothelial cell – roles in development and regeneration.

Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias (2021)
Journal Article
Vavouraki, N., Tomkins, J. E., Kara, E., Houlden, H., Hardy, J., Tindall, M. J., …Manzoni, C. (2021). Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias. iScience, 102484. https://doi.org/10.1016/j.isci.2021.102484

Effect of diet and non-esterified fatty acid levels on global transcriptomic profiles in circulating peripheral blood mononuclear cells in early lactation dairy cows (2021)
Journal Article
Cheng, Z., Wylie, A., Ferris, C., Ingvartsen, K., Wathes, D., & GplusE consortium, . (in press). Effect of diet and non-esterified fatty acid levels on global transcriptomic profiles in circulating peripheral blood mononuclear cells in early lactation dairy cows. Journal of Dairy Science,

Machine-learning based prediction of Cushing’s syndrome in dogs attending UK primary-care veterinary practice (2021)
Journal Article
Schofield, I., Brodbelt, D. C., Kennedy, N., Niessen, S. J. M., Church, D. B., Geddes, R. F., & O’Neill, D. G. (2021). Machine-learning based prediction of Cushing’s syndrome in dogs attending UK primary-care veterinary practice. Scientific Reports, 11(1), https://doi.org/10.1038/s41598-021-88440-z

Cushing’s syndrome is an endocrine disease in dogs that negatively impacts upon the quality-of-life of affected animals. Cushing’s syndrome can be a challenging diagnosis to confirm, therefore new methods to aid diagnosis are warranted. Four machine-... Read More about Machine-learning based prediction of Cushing’s syndrome in dogs attending UK primary-care veterinary practice.