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Predictors of laminitis development in a cohort of non-laminitic ponies

Knowles, Edward; Elliott, Jonathan; Harris, Patricia; Chang, Ruby; Menzies-Gow, Nicola


Edward Knowles

Jonathan Elliott

Patricia Harris

Ruby Chang

Nicola Menzies-Gow


Background: Quantifying the risk of laminitis development requires improvement.
Objectives: To identify the most useful physical examination, metabolic and management factors to predict future laminitis development in client-owned, non-laminitic ponies.
Study design: Prospective cohort
Methods: Physical examination, metabolic and management data were collected from a cohort of ponies six-monthly for up to four years. Ponies were monitored for the development of laminitis. Metabolic data included basal plasma concentrations of ACTH ([ACTH]), adiponectin ([adiponectin]), triglycerides and glucose. Serum insulin concentrations ([insulin]) were measured in the unfasted basal state ([insulin]T0) and 60 minutes ([insulin]T60) after administration of corn syrup (0.3ml/kg). Separate multivariable Cox proportional-hazards models were developed for physical, management/ signalment and metabolic data and later combined into two final models. Low, medium and high laminitis risk categories were then defined based on basal or T60 [insulin].
Results: 374 ponies and 891 pony-years were included in the main analysis. Laminitis incidence (95% confidence interval (C.I.)) was 4.8 (3.5-6.5) cases/100 pony-years. Laminitis development was associated with numerous univariable factors. Significant (p


Knowles, E., Elliott, J., Harris, P., Chang, R., & Menzies-Gow, N. (2021). Predictors of laminitis development in a cohort of non-laminitic ponies. Equine Veterinary Journal,

Journal Article Type Other
Acceptance Date Aug 24, 2021
Publication Date Aug 25, 2021
Deposit Date Nov 19, 2021
Publicly Available Date Aug 25, 2022
Print ISSN 0425-1644
Publisher Wiley
Peer Reviewed Not Peer Reviewed
Public URL