Predictors of laminitis development in a cohort of non-laminitic ponies
Knowles, Edward; Elliott, Jonathan; Harris, Patricia; Chang, Ruby; Menzies-Gow, Nicola
Background: Quantifying the risk of laminitis development requires improvement.
Objectives: To identify the most useful physical examination, metabolic and management factors to predict future laminitis development in client-owned, non-laminitic ponies.
Study design: Prospective cohort
Methods: Physical examination, metabolic and management data were collected from a cohort of ponies six-monthly for up to four years. Ponies were monitored for the development of laminitis. Metabolic data included basal plasma concentrations of ACTH ([ACTH]), adiponectin ([adiponectin]), triglycerides and glucose. Serum insulin concentrations ([insulin]) were measured in the unfasted basal state ([insulin]T0) and 60 minutes ([insulin]T60) after administration of corn syrup (0.3ml/kg). Separate multivariable Cox proportional-hazards models were developed for physical, management/ signalment and metabolic data and later combined into two final models. Low, medium and high laminitis risk categories were then defined based on basal or T60 [insulin].
Results: 374 ponies and 891 pony-years were included in the main analysis. Laminitis incidence (95% confidence interval (C.I.)) was 4.8 (3.5-6.5) cases/100 pony-years. Laminitis development was associated with numerous univariable factors. Significant (p
Knowles, E., Elliott, J., Harris, P., Chang, R., & Menzies-Gow, N. (2021). Predictors of laminitis development in a cohort of non-laminitic ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.31_13492
|Journal Article Type||Other|
|Acceptance Date||Aug 24, 2021|
|Publication Date||Aug 25, 2021|
|Deposit Date||Nov 19, 2021|
|Publicly Available Date||Aug 25, 2022|
|Peer Reviewed||Not Peer Reviewed|
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