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The genomic architecture of mastitis resistance in dairy sheep (2017)
Journal Article
Banos, G., Bramis, G., Bush, S. J., Clark, E. L., McCulloch, M. E. B., Smith, J., …Psifidi, A. (2017). The genomic architecture of mastitis resistance in dairy sheep. BMC Genomics, 18, 624. https://doi.org/10.1186/s12864-017-3982-1

Mastitis is the most prevalent disease in dairy sheep with major economic, hygienic and welfare implications. The disease persists in all dairy sheep production systems despite the implementation of improved management practises. Selective breeding f... Read More about The genomic architecture of mastitis resistance in dairy sheep.

Comparison of veterinary drugs and veterinary homeopathy: part 1 (2017)
Journal Article
Lees, P., Chambers, D., Pelligand, L., Toutain, P. L., Whiting, M., & Whitehead, M. L. (2017). Comparison of veterinary drugs and veterinary homeopathy: part 1. Veterinary Record, 181(7), 170-176. https://doi.org/10.1136/vr.104278

For many years after its invention around 1796, homeopathy was widely used in people and later in animals. Over the intervening period (1796-2016) pharmacology emerged as a science from Materia Medica (medicinal materials) to become the mainstay of v... Read More about Comparison of veterinary drugs and veterinary homeopathy: part 1.

Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats (2017)
Journal Article
Doodnaught, G. M., Monteiro, B. P., Benito, J., Edge, D., Beaudry, F., Pelligand, L., & Steagall, P. (2017). Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats. PLoS ONE, 12(4), w0176443. https://doi.org/10.1371/journal.pone.0176443

The aim of this study was to describe the joint pharmacokinetic-pharmacodynamic model and evaluate thermal antinociception of a high-concentration formulation of buprenorphine (Simbadol™) in cats.

What is the true in vitro potency of oxytetracycline for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida? (2017)
Journal Article
Dorey, L., Hobson, S., & Lees, P. (2017). What is the true in vitro potency of oxytetracycline for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida?. Journal of Veterinary Pharmacology and Therapeutics, 40(5), 517-529. https://doi.org/10.1111/jvp.12386

The pharmacodynamics of oxytetracycline was determined for pig respiratory tract pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida. Indices of potency were determined for the following: (i) two matrices, broth and pig serum; (ii) f... Read More about What is the true in vitro potency of oxytetracycline for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida?.

An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity (2016)
Journal Article
Holder, A., Mella, S., Palmer, D. B., Aspinall, R., & Catchpole, B. (2016). An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity. PLoS ONE, 11, e0165968. https://doi.org/10.1371/journal.pone.0165968

The age associated decline in immune function is preceded in mammals by a reduction in thymic output. Furthermore, there is increasing evidence of a link between immune competence and lifespan. One approach to determining thymic output is to quantify... Read More about An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity.

Single Nucleotide Polymorphisms in Major histocompatibility class II haplotypes are associated with potential resistance to inflammatory bowel disease in German shepherd dogs (2016)
Journal Article
Peiravan, A., Allenspach, K., Boag, A. M., Soutter, F., Holder, A. L., Catchpole, B., …Procoli, F. (2016). Single Nucleotide Polymorphisms in Major histocompatibility class II haplotypes are associated with potential resistance to inflammatory bowel disease in German shepherd dogs. Veterinary Immunology and Immunopathology, 182, 101-105. https://doi.org/10.1016/j.vetimm.2016.10.012

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease (2016)
Journal Article
Deas, E., Cremades, N., Angelova, P. R., Ludtmann, M. H. R., Yao, Z., Chen, S., …Abramov, A. Y. (2016). Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease. https://doi.org/10.1089/ars.2015.6343

Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown. In this study, we describe how aggregati... Read More about Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease.

MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR (2015)
Journal Article
Singh, Y., Garden, O. A., Lang, F., & Cobb, B. S. (2015). MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR. Journal of Immunology, 195(12), 5667-5677. https://doi.org/10.4049/jimmunol.1401875

CD4(+) regulatory T cells (Tregs) are essential for controlling immune responses and preventing autoimmunity. Their development requires regulation of gene expression by microRNAs (miRNAs). To understand miRNA function in Treg development, we searche... Read More about MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR.

Breed differences in development of anti-insulin antibodies in diabetic dogs and investigation of the role of dog leukocyte antigen (DLA) genes (2015)
Journal Article
Holder, A. L., Kennedy, L. J., Ollier, W. E. R., & Catchpole, B. (2015). Breed differences in development of anti-insulin antibodies in diabetic dogs and investigation of the role of dog leukocyte antigen (DLA) genes. Veterinary Immunology and Immunopathology, 167(3-4), 130-8. https://doi.org/10.1016/j.vetimm.2015.07.014

Administration of insulin for treatment of diabetes mellitus in dogs can stimulate an immune response, with a proportion of animals developing anti-insulin antibodies (AIA). For an IgG antibody response to occur, this would require B cell presentatio... Read More about Breed differences in development of anti-insulin antibodies in diabetic dogs and investigation of the role of dog leukocyte antigen (DLA) genes.

Comparison of gabapentin versus topiramate on clinically affected dogs with Chiari-like malformation and syringomyelia (2015)
Journal Article
Plessas, I. N., Volk, H. A., Rusbridge, C., Vanhaesebrouck, A. E., & Jeffery, N. D. (2015). Comparison of gabapentin versus topiramate on clinically affected dogs with Chiari-like malformation and syringomyelia. Veterinary Record, 177(11), 288-288. https://doi.org/10.1136/vr.103234

To date there is no evidence-based data for efficacious treatment of neuropathic pain in dogs with Chiari-like malformation (CM) and syringomyelia (SM). The objective of this prospective cross-over study was to compare the effect of gabapentin versus... Read More about Comparison of gabapentin versus topiramate on clinically affected dogs with Chiari-like malformation and syringomyelia.

Shh regulates chick Ebf1 gene expression in somite development (2015)
Journal Article
El-Magd, M. A., Allen, S. P., McGonnell, I. M., Mansour, A. A., Otto, A., & Patel, K. (2015). Shh regulates chick Ebf1 gene expression in somite development. Gene, 554(1), 87-95. https://doi.org/10.1016/j.gene.2014.10.028

The chick early B-cell factor 1 (cEbf1) is a member of EBF family of helix loop helix transcription factors. Recently, we have proved that cEbf1 expression in feather is regulated by Shh. It is therefore possible that the somitic expression of cEbf1... Read More about Shh regulates chick Ebf1 gene expression in somite development.

Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves (2013)
Journal Article
Brentnall, C., Cheng, Z. R., McKellar, Q. A., & Lees, P. (2013). Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves. Journal of Veterinary Pharmacology and Therapeutics, 36(4), 320-328. https://doi.org/10.1111/jvp.12000

A tissue cage model of inflammation in calves was used to determine the pharmacokinetic and pharmacodynamic properties of individual carprofen enantiomers, following the administration of the racemate. RS(±) carprofen was administered subcutaneously... Read More about Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves.