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Fate of CMY-2-encoding plasmids introduced into the human fecal microbiota by exogenous Escherichia coli (2019)
Journal Article
Anjum, M., Madsen, J. S., Nesme, J., Jana, B., Wiese, M., Jasinskyte, D., …Guardabassi, L. (2019). Fate of CMY-2-encoding plasmids introduced into the human fecal microbiota by exogenous Escherichia coli. Antimicrobial Agents and Chemotherapy, 63(5), https://doi.org/10.1128/AAC.02528-18

The gut is a hot spot for transfer of antibiotic resistance genes from ingested exogenous bacteria to the indigenous microbiota. The objective of this study was to determine the fate of two nearly identical blaCMY-2-harboring plasmids introduced into... Read More about Fate of CMY-2-encoding plasmids introduced into the human fecal microbiota by exogenous Escherichia coli.

The transmission dynamics of Campylobacter jejuni among broilers in semi-commercial farms in Jordan (2019)
Journal Article
Neves, M. I., Malkawi, I., Walker, M., Alaboudi, A., Abu-Basha, E., Blake, D. P., …Crotta, M. (2019). The transmission dynamics of Campylobacter jejuni among broilers in semi-commercial farms in Jordan. Epidemiology and Infection, 147, E134. https://doi.org/10.1017/S0950268818003308

Campylobacter is the leading cause of foodborne bacterial gastroenteritis in humans worldwide, often associated with the consumption of undercooked poultry. In Jordan, the majority of broiler chicken production occurs in semi-commercial farms, where... Read More about The transmission dynamics of Campylobacter jejuni among broilers in semi-commercial farms in Jordan.

Mycobacterium avium paratuberculosis infection of calves – The impact of dam infection status (2019)
Journal Article
Patterson, S., Bond, K., Green, M., Van Winden, S. C. L., & Guitian, J. (2019). Mycobacterium avium paratuberculosis infection of calves – The impact of dam infection status. Preventive Veterinary Medicine, https://doi.org/10.1016/j.prevetmed.2019.02.009

Johne’s disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a chronic condition of dairy cattle, and is endemic in the UK. Lack of understanding of the relative importance of different transmission routes reduces the impact of co... Read More about Mycobacterium avium paratuberculosis infection of calves – The impact of dam infection status.

Isolation and characterization of bacteriophages active against methicillin-resistant Staphylococcus pseudintermedius (2019)
Journal Article
Moodley, A., Kot, W., Nälgård, S., Jakociune, D., Neve, H., Hansen, L. H., …Vogensen, F. K. (2019). Isolation and characterization of bacteriophages active against methicillin-resistant Staphylococcus pseudintermedius. Research in Veterinary Science, 122, 81-85. https://doi.org/10.1016/j.rvsc.2018.11.008

We aimed to isolate and characterize bacteriophages (phages) with preferential activity against methicillin-resistant Staphylococcus pseudintermedius (MRSP), a multidrug-resistant canine pathogen. Four phages were isolated from canine faeces using tw... Read More about Isolation and characterization of bacteriophages active against methicillin-resistant Staphylococcus pseudintermedius.

Optimising the detectability of H5N1 and H5N6 highly pathogenic avian influenza viruses in Vietnamese live-bird markets (2019)
Journal Article
Vergne, T., Meyer, A., Long, P. T., Elkholly, D. A., Inui, K., Padungtod, P., …Pfeiffer, D. U. (2019). Optimising the detectability of H5N1 and H5N6 highly pathogenic avian influenza viruses in Vietnamese live-bird markets. https://doi.org/10.1038/s41598-018-37616-1

Live bird markets (LBMs) are major targets for avian influenza virus (AIV) surveillance programmes. While sampling the LBM environment has become a widely used alternative to the labour-intensive sampling of live poultry, the design of surveillance p... Read More about Optimising the detectability of H5N1 and H5N6 highly pathogenic avian influenza viruses in Vietnamese live-bird markets.

Backyard poultry production in Chile: animal health management and contribution to food access in an upper middle-income country (2019)
Journal Article
Di Pillo, F., Anríquez, G., Alarcón, P., Jimenez-Bluhm, P., Galdames, P., Nieto, V., …Hamilton-West, C. (2019). Backyard poultry production in Chile: animal health management and contribution to food access in an upper middle-income country. Preventive Veterinary Medicine, 164, 41-48. https://doi.org/10.1016/j.prevetmed.2019.01.008

Backyard production systems (BPS) that involve poultry are a good way to improve food security and poverty alleviation. Few studies have been carried out to quantify the contribution of poultry production to these households and the constraints they... Read More about Backyard poultry production in Chile: animal health management and contribution to food access in an upper middle-income country.

Rapidly assessing the risks of infectious diseases to wildlife species (2019)
Journal Article
Beauvais, W., Zuther, S., Villeneuve, C., Kock, R. A., & Guitian, J. (2019). Rapidly assessing the risks of infectious diseases to wildlife species. Royal Society Open Science, 6(1), https://doi.org/10.1098/rsos.181043

Predicting the likelihood of rare events is increasingly demanded by risk managers. A key challenge is dealing with different types of uncertainty, including epistemic uncertainties (lack of knowledge), stochasticity (inherent randomness) and natural... Read More about Rapidly assessing the risks of infectious diseases to wildlife species.

Pilot study of head conformation changes over time in the Cavalier King Charles spaniel breed (2019)
Journal Article
Knowler, S. P., Gillstedt, L., Mitchell, T. J., Jovanovik, J., Volk, H. A., & Rusbridge, C. (2019). Pilot study of head conformation changes over time in the Cavalier King Charles spaniel breed. Veterinary Record, 184(4), https://doi.org/10.1136/vr.105135

Modern interpretation of head conformation in the Cavalier King Charles spaniel (CKCS) has favoured a smaller, more exaggerated, brachycephalic type than originally described in the 1929 breed standard. Recent research studies identified brachycephal... Read More about Pilot study of head conformation changes over time in the Cavalier King Charles spaniel breed.

Genome reconstruction of a novel carbohydrate digesting bacterium from the chicken caecal microflora (2019)
Journal Article
Hinsu, A. T., Pandit, R. J., Patel, S. H., Psifidi, A., Tomley, F. M., Das, S. K., …Joshi, C. G. (2019). Genome reconstruction of a novel carbohydrate digesting bacterium from the chicken caecal microflora. https://doi.org/10.1016/j.mgene.2019.01.002

The advent of metagenomics using Next-Generation Sequencing (NGS) has led to the acquisition of unprecedented quantities of bacterial sequence data. One use for these data is the recovery of complete genomes of uncultivable, and thus uncharacterised,... Read More about Genome reconstruction of a novel carbohydrate digesting bacterium from the chicken caecal microflora.

GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice (2019)
Journal Article
Puig, B., Altmeppen, H. C., Linsenmeier, L., Chakroun, K., Wegwitz, F., Piontek, U. K., …Glatzel, M. (2019). GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice. PLoS Pathogens, 15(1), e1007520. https://doi.org/10.1371/journal.ppat.1007520

The cellular prion protein (PrPC) is a cell surface glycoprotein attached to the membrane by a glycosylphosphatidylinositol (GPI)-anchor and plays a critical role in transmissible, neurodegenerative and fatal prion diseases. Alterations in membrane a... Read More about GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice.

Plasticity of Amino Acid Residue 145 Near the Receptor Binding Site of H3 Swine Influenza A Viruses and Its Impact on Receptor Binding and Antibody Recognition (2019)
Journal Article
Santos, J. J. S., Abente, E. J., Obadan, A. O., Thompson, A. J., Ferreri, L., Geiger, G., …Perez, D. R. (2019). Plasticity of Amino Acid Residue 145 Near the Receptor Binding Site of H3 Swine Influenza A Viruses and Its Impact on Receptor Binding and Antibody Recognition. Journal of Virology, 93(2), e01413-18. https://doi.org/10.1128/JVI.01413-18

The hemagglutinin (HA), a glycoprotein on the surface of influenza A virus (IAV), initiates the virus life cycle by binding to terminal sialic acid (SA) residues on host cells. The HA gradually accumulates amino acid substitutions that allow IAV to e... Read More about Plasticity of Amino Acid Residue 145 Near the Receptor Binding Site of H3 Swine Influenza A Viruses and Its Impact on Receptor Binding and Antibody Recognition.

Monkeypox — Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era (2019)
Journal Article
Petersen, E., Abubakar, I., Ihekweazu, C., Heymann, D., Ntoumi, F., Blumberg, L., …Zumla, A. (2019). Monkeypox — Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era. International Journal of Infectious Diseases, 78, 78-84. https://doi.org/10.1016/j.ijid.2018.11.008

The identification of monkeypox in 3 separate patients in the United Kingdom in September raised media and political attention on an emerging public health threat. Nigeria, whose last confirmed case of monkeypox was in 1978, is currently experiencing... Read More about Monkeypox — Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era.

A study of tuberculosis in road traffic-killed badgers on the edge of the British bovine TB epidemic area (2018)
Journal Article
Sandoval Barron, E., Swift, B. M. C., Chantrey, J., Christley, R., Gardner, R., Jewell, C., …Bennett, M. (2018). A study of tuberculosis in road traffic-killed badgers on the edge of the British bovine TB epidemic area. https://doi.org/10.1038/s41598-018-35652-5

The role of badgers in the geographic expansion of the bovine tuberculosis (bTB) epidemic in England is unknown: indeed there have been few published studies of bTB in badgers outside of the Southwest of England where the infection is now endemic in... Read More about A study of tuberculosis in road traffic-killed badgers on the edge of the British bovine TB epidemic area.

Comparison of 2016–17 and Previous Epizootics of Highly Pathogenic Avian Influenza H5 Guangdong Lineage in Europe (2018)
Journal Article
Alarcon, P., Brouwer, A., Vekatesh, D., Duncan, D., Dovas, C. I., Georgiades, G., …Brown, I. H. (2018). Comparison of 2016–17 and Previous Epizootics of Highly Pathogenic Avian Influenza H5 Guangdong Lineage in Europe. https://doi.org/10.3201/eid2412.171860

We analyzed the highly pathogenic avian influenza (HPAI) H5 epizootic of 2016–17 in Europe by epidemiologic and genetic characteristics and compared it with 2 previous epizootics caused by the same H5 Guangdong lineage. The 2016–17 epizootic was the... Read More about Comparison of 2016–17 and Previous Epizootics of Highly Pathogenic Avian Influenza H5 Guangdong Lineage in Europe.

Dissecting the Genomic Architecture of Resistance to Eimeria maxima Parasitism in the Chicken (2018)
Journal Article
Boulton, K., Nolan, M. J., Wu, Z., Riggio, V., Matika, O., Harman, K., …Psifidi, A. (2018). Dissecting the Genomic Architecture of Resistance to Eimeria maxima Parasitism in the Chicken. Frontiers in Genetics, 9, https://doi.org/10.3389/fgene.2018.00528

Coccidiosis in poultry, caused by protozoan parasites of the genus Eimeria, is an intestinal disease with substantial economic impact. With the use of anticoccidial drugs under public and political pressure, and the comparatively higher cost of live-... Read More about Dissecting the Genomic Architecture of Resistance to Eimeria maxima Parasitism in the Chicken.

Decreased nematode clearance & anti-phosphorylcholine specific IgM responses in mannose-binding lectin deficient mice (2018)
Journal Article
Ahmed, R., Cadman, E. T., Snapper, C. M., & Lawrence, R. A. (2018). Decreased nematode clearance & anti-phosphorylcholine specific IgM responses in mannose-binding lectin deficient mice. https://doi.org/10.1111/imcb.12219

Brugia malayi is a nematode that causes human lymphatic filariasis. Previously, we showed that mannose binding lectin (MBL) ‐A is necessary for clearance of B. malayi microfilariae in mice and presence of MBL‐A is linked with maximal levels of parasi... Read More about Decreased nematode clearance & anti-phosphorylcholine specific IgM responses in mannose-binding lectin deficient mice.

Draft genome assembly of the poultry red mite, Dermanyssus gallinae (2018)
Journal Article
Burgess, S. T. G., Bartley, K., Nunn, F., Wright, H. W., Hughes, M., Gemmell, M., …Nisbet, A. J. (2018). Draft genome assembly of the poultry red mite, Dermanyssus gallinae. Microbiology Resource Announcements, 7(18), https://doi.org/10.1128/MRA.01221-18

The poultry red mite, Dermanyssus gallinae, is a major worldwide concern in the egg-laying industry. Here, we report the first draft genome assembly and gene prediction of Dermanyssus gallinae, based on combined PacBio and MinION long-read de novo se... Read More about Draft genome assembly of the poultry red mite, Dermanyssus gallinae.

Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators (2018)
Journal Article
Baker, K. R., Jana, B., Hansen, A. M., Vissing, K. J., Nielsen, H. M., Franzyk, H., & Guardabassi, L. (2018). Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators. International Journal of Antimicrobial Agents, 53(6), 868-872. https://doi.org/10.1016/j.ijantimicag.2018.10.025

Gram-negative bacterial pathogens are intrinsically resistant to several antibiotics that are not able to penetrate the cell envelope barrier. The aim of this study was to identify peptides that at low concentrations induce susceptibility to these an... Read More about Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators.