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Decreased nematode clearance & anti-phosphorylcholine specific IgM responses in mannose-binding lectin deficient mice

Ahmed, R; Cadman, E T; Snapper, C M; Lawrence, R A

Authors

R Ahmed

E T Cadman

C M Snapper

R A Lawrence



Abstract

Brugia malayi is a nematode that causes human lymphatic filariasis. Previously, we showed that mannose binding lectin (MBL) ?A is necessary for clearance of B. malayi microfilariae in mice and presence of MBL?A is linked with maximal levels of parasite?specific IgM. Common human MBL gene polymorphisms result in low MBL expression and lead to recurring bacterial infections. Furthermore, these low?expressing human MBL polymorphisms result in greatly increased susceptibility to lymphatic filarial infection. Indeed, gain of new filarial infections over a 30?year period are 10?fold higher in people with low, compared to high, MBL?expression phenotypes. Human MBL closely resembles mouse MBL?C, rather than MBL?A, therefore we examined the role of mouse MBL?C in clearance of microfilariae. Absence of MBL?C alone, or both MBL?A and ?C, resulted in delayed clearance of microfilariae and reduced parasite?specific IgM in mice. There were few profound changes in B cell sub?populations or in the ability of MBL?deficient mice to respond to T?dependent or T?independent antigens. However, absence of MBL?A and/or MBL?C resulted in reduced IgM to phosphorylcholine, a constituent of filarial and bacterial antigens, suggesting that inability to form proficient antibody responses to this moiety leads to lack of microfilarial clearance and overall susceptibility to filariasis.

Citation

Ahmed, R., Cadman, E. T., Snapper, C. M., & Lawrence, R. A. (2018). Decreased nematode clearance & anti-phosphorylcholine specific IgM responses in mannose-binding lectin deficient mice. https://doi.org/10.1111/imcb.12219

Journal Article Type Article
Acceptance Date Nov 12, 2018
Publication Date Nov 20, 2018
Deposit Date Nov 29, 2018
Publicly Available Date Nov 21, 2019
Journal Immunology & Cell Biology
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1111/imcb.12219
Public URL https://rvc-repository.worktribe.com/output/1385102

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