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Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts (2015)
Journal Article
Tivers, M. S., Lipscomb, V. J., Smith, K. C., Wheeler-Jones, C. P. D., & House, A. K. (2015). Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts. https://doi.org/10.1016/j.tvjl.2015.07.006

Surgical attenuation of a congenital portosystemic shunt (CPSS) results in increased portal vein perfusion, liver growth and clinical improvement. Portal lipopolysaccharide (LPS) is implicated in liver regeneration via toll-like receptor (TLR) 4 medi... Read More about Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts.

Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation (2015)
Journal Article
Thorpe, C. T., Chaudhry, S., Lei, I., Varone, A., Riley, G. P., Birch, H. L., Clegg, P. D., & Screen, H. R. (2015). Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation. https://doi.org/10.1111/sms.12333

Tendon injury is thought to involve both damage accumulation within the matrix and an accompanying cell response. While several studies have characterized cell and matrix response in chronically injured tendons, few have assessed the initial response... Read More about Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation.

The complex aerodynamic footprint of desert locusts revealed by large-volume tomographic particle image velocimetry (2015)
Journal Article
Henningsson, P., Michaelis, D., Nakata, T., Schanz, D., Geisler, R., Schroeder, A., & Bomphrey, R. J. (2015). The complex aerodynamic footprint of desert locusts revealed by large-volume tomographic particle image velocimetry. https://doi.org/10.1098/rsif.2015.0119

Particle image velocimetry has been the preferred experimental technique with which to study the aerodynamics of animal flight for over a decade. In that time, hardware has become more accessible and the software has progressed from the acquisition o... Read More about The complex aerodynamic footprint of desert locusts revealed by large-volume tomographic particle image velocimetry.

Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis (2015)
Journal Article
Akbareian, S. E., Pitsillides, A. A., Macharia, R. G., & McGonnell, I. M. (2015). Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis. Journal of Anatomy, 226(6), 560-574. https://doi.org/10.1111/joa.12304

Cranial foramina are holes within the skull, formed during development, allowing entry and exit of blood vessels and nerves. Once formed they must remain open, due to the vital structures they contain, i.e. optic nerves, jugular vein, carotid artery,... Read More about Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis.

A large-scale proteogenomics study of apicomplexan pathogens-Toxoplasma gondii and Neospora caninum (2015)
Journal Article
Krishna, R., Xia, D., Sanderson, S., Shanmugasundram, A., Vermont, S., Bernal, A., Daniel-Naguib, G., Ghali, F., Brunk, B. P., Roos, D. S., Wastling, J. M., & Jones, A. R. (2015). A large-scale proteogenomics study of apicomplexan pathogens-Toxoplasma gondii and Neospora caninum. Proteomics, 15(15), 261828. https://doi.org/10.1002/pmic.201400553

Proteomics data can supplement genome annotation efforts, for example being used to confirm gene models or correct gene annotation errors. Here, we present a large‐scale proteogenomics study of two important apicomplexan pathogens: Toxoplasma gondii... Read More about A large-scale proteogenomics study of apicomplexan pathogens-Toxoplasma gondii and Neospora caninum.

Randomized placebo-controlled clinical trial of a new chewable formulation of amlodipine for the treatment of hypertension in client-owned cats (2015)
Journal Article
Huhtinen, M., Derre, G., Renoldi, H. J., Rinkinen, M., Adler, K., Aspegren, J., Zemirline, C., & Elliott, J. (2015). Randomized placebo-controlled clinical trial of a new chewable formulation of amlodipine for the treatment of hypertension in client-owned cats. Journal of Veterinary Internal Medicine, 29(3), 786-793. https://doi.org/10.1111/jvim.12589

Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis (2015)
Journal Article
Zolfaghari, P. S., Carré, J. E., Parker, N., Curtin, N. A., Duchen, M. R., & Singer, M. (2015). Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis. https://doi.org/10.1152/ajpendo.00562.2014

Muscle dysfunction is a common feature of severe sepsis and multi-organ failure. Recent evidence implicates bioenergetic dysfunction and oxidative damage as important underlying pathophysiological mechanisms. Increased abundance of uncoupling protein... Read More about Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis.