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Outputs (123)

Endothelial SHIP2 suppresses Nox2 NADPH oxidase-dependent vascular oxidative stress, endothelial dysfunction and systemic insulin resistance (2017)
Journal Article
Watt, N. T., Gage, M. C., Patel, P. A., Viswambharan, H., Sukumar, P., Galloway, S., …Cubbon, R. M. (2017). Endothelial SHIP2 suppresses Nox2 NADPH oxidase-dependent vascular oxidative stress, endothelial dysfunction and systemic insulin resistance. Diabetes, 66(11), 2808-2821. https://doi.org/10.2337/db17-0062

Shc homology 2–containing inositol 5′ phosphatase-2 (SHIP2) is a lipid phosphatase that inhibits insulin signaling downstream of phosphatidylinositol 3-kinase (PI3K); its role in vascular function is poorly understood. To examine its role in endothel... Read More about Endothelial SHIP2 suppresses Nox2 NADPH oxidase-dependent vascular oxidative stress, endothelial dysfunction and systemic insulin resistance.

Physiological reactivity to spontaneously occurring seizure activity in dogs with epilepsy and their carers (2017)
Journal Article
Packer, R. M. A., Volk, H. A., & Fowkes, R. C. (2017). Physiological reactivity to spontaneously occurring seizure activity in dogs with epilepsy and their carers. Physiology and Behavior, 177, 27-33. https://doi.org/10.1016/j.physbeh.2017.04.008

There is a complex bidirectional relationship between stress and epilepsy. Stressful stimuli and subsequent cortisol release act as a trigger for seizure activity in some individuals with epilepsy, and seizure activity itself may act as a stressor to... Read More about Physiological reactivity to spontaneously occurring seizure activity in dogs with epilepsy and their carers.

Stable sulforaphane protects against gait anomalies and modifies bone microarchitecture in the spontaneous STR/Ort model of osteoarthritis (2017)
Journal Article
Javaheri, B., Poulet, B., Aljazzar, A., De Souza, R., Piles, M., Hopkinson, M., …Pitsillides, A. A. (2017). Stable sulforaphane protects against gait anomalies and modifies bone microarchitecture in the spontaneous STR/Ort model of osteoarthritis. BONE, 103, 308-317. https://doi.org/10.1016/j.bone.2017.07.028

Osteoarthritis (OA), affecting joints and bone, causes physical gait disability with huge socio-economic burden; treatment remains palliative. Roles for antioxidants in protecting against such chronic disorders have been examined previously. Sulforap... Read More about Stable sulforaphane protects against gait anomalies and modifies bone microarchitecture in the spontaneous STR/Ort model of osteoarthritis.

In search of morphological modules: a systematic review (2017)
Journal Article
Esteve-Altava, B. (2017). In search of morphological modules: a systematic review. Biological Reviews, 92(3), 1332-1347. https://doi.org/10.1111/brv.12284

Morphological modularity arises in complex living beings due to a semi-independent inheritance, development, and function of body parts. Modularity helps us to understand the evolvability and plasticity of organismal form, and how morphological varia... Read More about In search of morphological modules: a systematic review.

Cell cycle-dependent phosphorylation of Theileria annulata schizont surface proteins (2017)
Journal Article
Wiens, O., Xia, D., Von Schubert, C., Wastling, J. M., Dobbelaere, D. A., Heussler, V. T., & Woods, K. L. (2017). Cell cycle-dependent phosphorylation of Theileria annulata schizont surface proteins. PLoS ONE, 9(7), e103821. https://doi.org/10.1371/journal.pone.0103821

The invasion of Theileria sporozoites into bovine leukocytes is rapidly followed by the destruction of the surrounding host cell membrane, allowing the parasite to establish its niche within the host cell cytoplasm. Theileria infection induces host c... Read More about Cell cycle-dependent phosphorylation of Theileria annulata schizont surface proteins.

Tempo and mode of performance evolution across multiple independent origins of adhesive toe pads in lizards (2017)
Journal Article
Hagey, T. J., Uyeda, J. C., Crandell, K. E., Cheney, J. A., Autumn, K., & Harmon, L. J. (2017). Tempo and mode of performance evolution across multiple independent origins of adhesive toe pads in lizards. Evolution, 71(10), 2344-2358. https://doi.org/10.1111/evo.13318

Understanding macroevolutionary dynamics of trait evolution is an important endeavor in evolutionary biology. Ecological opportunity can liberate a trait as it diversifies through trait space, while genetic and selective constraints can limit diversi... Read More about Tempo and mode of performance evolution across multiple independent origins of adhesive toe pads in lizards.

Investigation of the association between serum protein concentrations and concurrent chronic kidney disease in hyperthyroid cats (2017)
Journal Article
Williams, T. L., Elliott, J., Syme, H. M., & Archer, J. (2017). Investigation of the association between serum protein concentrations and concurrent chronic kidney disease in hyperthyroid cats. Research in Veterinary Science, 115, 412-417. https://doi.org/10.1016/j.rvsc.2017.07.023

Our objective was to identify if changes in serum protein concentrations occur in hyperthyroidism and to assess their association with the development of azotaemia following treatment. Initially non-azotaemic hyperthyroid cats and healthy older ca... Read More about Investigation of the association between serum protein concentrations and concurrent chronic kidney disease in hyperthyroid cats.

A distinctive patchy osteomalacia characterises Phospho1-deficient mice (2017)
Journal Article
Boyde, A., Staines, K. A., Javaheri, B., Millan, J. L., Pitsillides, A. A., & Farquharson, C. (2017). A distinctive patchy osteomalacia characterises Phospho1-deficient mice. Journal of Anatomy, 231(2), 293-308. https://doi.org/10.1111/joa.12628

The phosphatase PHOSPHO1 is involved in the initiation of biomineralisation. Bones in Phospho1 knockout (KO) mice show histological osteomalacia with frequent bowing of long bones and spontaneous fractures: they contain less mineral, with smaller min... Read More about A distinctive patchy osteomalacia characterises Phospho1-deficient mice.

Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study (2017)
Journal Article
Hezzell, M. J., Boswood, A., Lopez-Alvarez, J., Lotter, N. S., & Elliott, J. (2017). Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study. Journal of Veterinary Cardiology, 19(4), 325-328. https://doi.org/10.1016/j.jvc.2017.06.001

Spironolactone improves outcome in dogs with advanced myxomatous mitral valve disease (MMVD). Its efficacy in preclinical MMVD is unknown. The hypothesis was the administration of spironolactone to dogs with compensated MMVD demonstrating risk factor... Read More about Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study.