Outputs (108)

Integrating morphology and in vivo skeletal mobility with digital models to infer function in brittle star arms (2018)
Journal Article
Clark, E. G., Hutchinson, J. R., Darroch, S. A. F., Mongiardino Koch, N., Bady, T. R., Smith, S. A., & Briggs, D. E. G. (2018). Integrating morphology and in vivo skeletal mobility with digital models to infer function in brittle star arms. Journal of Anatomy, 233(6), 696-714. https://doi.org/10.1111/joa.12887

Brittle stars (Phylum Echinodermata, Class Ophiuroidea) have evolved rapid locomotion employing muscle and skeletal elements within their (usually) five arms to apply forces in a manner analogous to that of vertebrates. Inferring the inner workings o... Read More about Integrating morphology and in vivo skeletal mobility with digital models to infer function in brittle star arms.

Chromosome Level Genome Assembly and Comparative Genomics between Three Falcon Species Reveals an Unusual Pattern of Genome Organisation (2018)
Journal Article
Joseph, S., O'Connor, R. E., Al Mutery, A., Watson, M., Larkin, D. M., & Griffin, D. (2018). Chromosome Level Genome Assembly and Comparative Genomics between Three Falcon Species Reveals an Unusual Pattern of Genome Organisation. Diversity, 10(4), 113. https://doi.org/10.3390/d10040113

Whole genome assemblies are crucial for understanding a wide range of aspects of falcon biology, including morphology, ecology, and physiology, and are thus essential for their care and conservation. A key aspect of the genome of any species is its k... Read More about Chromosome Level Genome Assembly and Comparative Genomics between Three Falcon Species Reveals an Unusual Pattern of Genome Organisation.

Survival after diagnosis of hypertension in cats attending primary care practice in the UK (2018)
Journal Article
Chang, Y. M., Brodbelt, D. C., Elliott, J., & Conroy, M. C. (2018). Survival after diagnosis of hypertension in cats attending primary care practice in the UK. Journal of Veterinary Internal Medicine, 32(6), 1846-1855. https://doi.org/10.1111/jvim.15307

Background: Hypertension is common in older cats. There is limited evidence for predictors of
survival after diagnosis.
Hypothesis/Objectives: Investigate blood pressure assessment (BPA) and hypertension diagnosis
in cats attending UK primary care... Read More about Survival after diagnosis of hypertension in cats attending primary care practice in the UK.

Reconstruction of avian ancestral karyotypes reveals differences in the evolutionary history of macro- and microchromosomes (2018)
Journal Article
Damas, J., Kim, J., Farré, M., Griffin, D. K., & Larkin, D. M. (2018). Reconstruction of avian ancestral karyotypes reveals differences in the evolutionary history of macro- and microchromosomes. Genome Biology, 19(155), https://doi.org/10.1186/s13059-018-1544-8

Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy (2018)
Journal Article
Amoasii, L., Hildyard, J. C. W., Li, H., Sanchez-Ortiz, E., Mireault, A., Caballero, D., Harron, R., Stathopoulou, T.-R., Massey, C. A., Shelton, J. M., Bassel-Duby, R., Piercy, R. J., & Olson, E. N. (2018). Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Science, 362(6410), 86-91. https://doi.org/10.1126/science.aau1549

Mutations in the gene encoding dystrophin, a protein that maintains muscle integrity and function, cause Duchenne muscular dystrophy (DMD). The deltaE50-MD dog model of DMD harbors a mutation corresponding to a mutational “hotspot” in the human DMD g... Read More about Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy.

Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy (2018)
Journal Article
Rocha-Ferreira, E., Poupon, L., Zelco, A., Leverin, A. L., Nair, S., Jonsdotter, A., Carlsson, Y., Thornton, C., Hagberg, H., & Rahim, A. A. (2018). Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy. Brain, 141(10), 2925-2942. https://doi.org/10.1093/brain/awy220

Hypoxic-ischaemic encephalopathy remains a global health burden. Despite medical advances and treatment with therapeutic hypothermia, over 50% of cooled infants are not protected and still develop lifelong neurodisabilities, including cerebral palsy.... Read More about Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy.

Simulation of muscle-powered jumping with hardware-in-the-loop ground interaction (2018)
Journal Article
Eberhard, E. A., & Richards, C. T. (2018). Simulation of muscle-powered jumping with hardware-in-the-loop ground interaction. https://doi.org/10.1109/AIM.2018.8452298

We developed a novel reverse haptic interface to augment forward dynamic simulations with real-world contact forces. In contrast with traditional haptics, in which a realworld user drives an interaction with a simulated environment, reverse haptics a... Read More about Simulation of muscle-powered jumping with hardware-in-the-loop ground interaction.

Lipoma in dogs under primary veterinary care in the UK: prevalence and breed associations (2018)
Journal Article
O'Neill, D. G., Corah, C. H., Church, D. B., Brodbelt, D. C., & Rutherford, L. (2018). Lipoma in dogs under primary veterinary care in the UK: prevalence and breed associations. Canine Genetics and Epidemiology, 5(9), https://doi.org/10.1186/s40575-018-0065-9

Common Traits Spark the Mitophagy/Xenophagy Interplay (2018)
Journal Article
Singh, A., Kendall, S. L., & Campanella, M. (2018). Common Traits Spark the Mitophagy/Xenophagy Interplay. Frontiers in Physiology, 9, https://doi.org/10.3389/fphys.2018.01172

Selective autophagy contributes to the wellbeing of eukaryotic cells by recycling cellular components, disposing damaged organelles, and removing pathogens, amongst others. Both the quality control process of selective mitochondrial autophagy (Mitoph... Read More about Common Traits Spark the Mitophagy/Xenophagy Interplay.

The scaling or ontogeny of human gait kinetics and walk-run transition: The implications of work vs. peak power minimization (2018)
Journal Article
Usherwood, J. R., Hubel, T. Y., Smith, B. J. H., Self Davies, Z. T., & Sobota, G. (2018). The scaling or ontogeny of human gait kinetics and walk-run transition: The implications of work vs. peak power minimization. Journal of Biomechanics, 81, 12-21. https://doi.org/10.1016/j.jbiomech.2018.09.004

A simple model is developed to find vertical force profiles and stance durations that minimize either limb mechanical work or peak power demands during bipedal locomotion. The model predicts that work minimization is achieved with a symmetrical verti... Read More about The scaling or ontogeny of human gait kinetics and walk-run transition: The implications of work vs. peak power minimization.