Outputs (108)

Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter (2018)
Journal Article
Read, J. E., Cabrera-Sharp, V., Kitscha, P., Cartwright, J. E., King, P. J., Fowkes, R. C., & De Mestre, A. M. (2018). Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter. Frontiers in Endocrinology, 9, https://doi.org/10.3389/fendo.2018.00195

Equine chorionic gonadotrophin (eCG) is a placental glycoprotein critical for early equine pregnancy and used therapeutically in a number of species to support reproductive activity. The factors in trophoblast that transcriptionally regulate eCGβ-sub... Read More about Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter.

Movement patterns and athletic performance of leopards in the Okavango Delta (2018)
Journal Article
Hubel, T. Y., Golabek, K. A., Rafiq, K., Weldon McNutt, J., & Wilson, A. M. (2018). Movement patterns and athletic performance of leopards in the Okavango Delta. Proceedings of the Royal Society B: Biological Sciences, 285(4), 1017-1027. https://doi.org/10.1098/rspb.2017.2622

Although leopards are the most widespread of all the big cats and are known for their adaptability, they are elusive and little is known in detail about their movement and hunting energetics. We used high-resolution GPS/IMU (inertial measurement unit... Read More about Movement patterns and athletic performance of leopards in the Okavango Delta.

Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling (2018)
Journal Article
Al-Rashed, F., Calay, D., Lang, M., Thornton, C., Bauer, A., Kiprianos, A., Haskard, D. O., Seneviratne, A., Boyle, J. J., Schönthal, A. H., Wheeler-Jones, C. P. D., & Mason, J. C. (2018). Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling. https://doi.org/10.1038/s41598-018-24548-z

Although concern remains about the athero-thrombotic risk posed by cyclo-oxygenase (COX)-2-selective inhibitors, recent data implicates rofecoxib, while celecoxib appears equivalent to NSAIDs naproxen and ibuprofen. We investigated the hypothesis tha... Read More about Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling.

TWEAK Receptor Deficiency Has Opposite Effects on Female and Male Mice Subjected to Neonatal Hypoxia-Ischemia (2018)
Journal Article
Kichev, A., Baburamani, A. A., Vontell, R., Gressens, P., Burkly, L., Thornton, C., & Hagberg, H. (2018). TWEAK Receptor Deficiency Has Opposite Effects on Female and Male Mice Subjected to Neonatal Hypoxia-Ischemia. Frontiers in Neurology, 9(230), https://doi.org/10.3389/fneur.2018.00230

Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine member of the TNF family. TWEAK binds to its only known receptor, Fn14, enabling it to activate downstream signaling processes in response to tissue inju... Read More about TWEAK Receptor Deficiency Has Opposite Effects on Female and Male Mice Subjected to Neonatal Hypoxia-Ischemia.

A physical model suggests that hip-localized balance sense in birds improves state estimation in perching: implications for bipedal robots (2018)
Journal Article
Urbina-Meléndez, D., Jalaleddini, K., Daley, M. A., & Valero-Cuevas, F. J. (2018). A physical model suggests that hip-localized balance sense in birds improves state estimation in perching: implications for bipedal robots. Frontiers in Robotics and AI, 5(38), https://doi.org/10.3389/frobt.2018.00038

In addition to a vestibular system, birds uniquely have a balance-sensing organ within the pelvis, called the lumbosacral organ (LSO). The LSO is well developed in terrestrial birds, possibly to facilitate balance control in perching and terrestrial... Read More about A physical model suggests that hip-localized balance sense in birds improves state estimation in perching: implications for bipedal robots.

Sperm preparation through Sephadex™ filtration improves in vitro fertilization rate of buffalo oocytes (2018)
Journal Article
Husna, A. U., Azam, A., Qadeer, S., Awan, M. A., Nasreen, S., Shahzad, Q., Fouladi-Nashta, A. A., Khalid, M., & Akhter, S. (2018). Sperm preparation through Sephadex™ filtration improves in vitro fertilization rate of buffalo oocytes. Reproduction in Domestic Animals, 53(2), 377-384. https://doi.org/10.1111/rda.13117

Routinely, swim-up method is used to separate high-quality sperm; however, long processing time and close cell-to-cell contact during the centrifugation step are inevitable elements of oxidative stress to sperm. The objective was to evaluate Sephadex... Read More about Sperm preparation through Sephadex™ filtration improves in vitro fertilization rate of buffalo oocytes.

Inhibition of arterial medial calcification and bone mineralization by extracellular nucleotides: The same functional effect mediated by different cellular mechanisms (2018)
Journal Article
Patel, J. J., Zhu, D., Opdebeeck, B., D'Haese, P., Millán, J. L., Bourne, L. E., Wheeler-Jones, C. P. D., Arnett, T. R., MacRae, V. E., & Orriss, I. R. (2018). Inhibition of arterial medial calcification and bone mineralization by extracellular nucleotides: The same functional effect mediated by different cellular mechanisms. Journal of Cellular Physiology, 233(4), 3230-3243. https://doi.org/10.1002/jcp.26166

Arterial medial calcification (AMC) is thought to share some outward similarities to skeletal mineralization and has been associated with the transdifferentiation of vascular smooth muscle cells (VSMCs) to an osteoblast‐like phenotype. ATP and UTP ha... Read More about Inhibition of arterial medial calcification and bone mineralization by extracellular nucleotides: The same functional effect mediated by different cellular mechanisms.

Functional rescue of dystrophin deficiency in mice caused by frameshift mutations using Campylobacter jejuni Cas9 (2018)
Journal Article
Koo, T., Lu-Nguyen, N. B., Malerba, A., Kim, E., Kim, D., Cappellari, O., Cho, H.-Y., Dickson, G., Popplewell, L., & Kim, J.-S. (2018). Functional rescue of dystrophin deficiency in mice caused by frameshift mutations using Campylobacter jejuni Cas9. Molecular Therapy, https://doi.org/10.1016/j.ymthe.2018.03.018

Duchenne muscular dystrophy (DMD) is a fatal, X-linked muscle wasting disease caused by mutations in the DMD gene. In 51% of DMD cases, a reading frame is disrupted because of deletion of several exons. Here, we show that CjCas9 derived from Campylob... Read More about Functional rescue of dystrophin deficiency in mice caused by frameshift mutations using Campylobacter jejuni Cas9.

Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice (2018)
Journal Article
Javaheri, B., Razi, H., Piles, M., De Souza, R., Chang, Y. M., Maric-Mur, I., Hopkinson, M., Lee, P. D., & Pitsillides, A. A. (2018). Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice. Osteoarthritis and Cartilage, 26(6), 807-817. https://doi.org/10.1016/j.joca.2018.03.008

Human osteoarthritis (OA) is detected only at late stages. Male STR/Ort mice develop knee OA spontaneously with known longitudinal trajectory, offering scope to identify OA predisposing factors. We exploit the lack of overt OA in female STR/Ort and i... Read More about Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice.

Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking (2018)
Journal Article
Critchley, W. R., Pellet-Many, C., Ringham-Terry, B., Harrison, M. A., Zachary, I. C., & Ponnamblalam, S. (2018). Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking. Cells, 7(3), https://doi.org/10.3390/cells7030022

Receptor tyrosine kinases (RTKs) are membrane-based sensors that enable rapid communication between cells and their environment. Evidence is now emerging that interdependent regulatory mechanisms, such as membrane trafficking, ubiquitination, proteol... Read More about Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking.