Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice

Javaheri, B; Razi, H; Piles, M; De Souza, R; Chang, Y M; Maric-Mur, I; Hopkinson, M; Lee, P D; Pitsillides, A A

Abstract

Human osteoarthritis (OA) is detected only at late stages. Male STR/Ort mice develop knee OA spontaneously with known longitudinal trajectory, offering scope to identify OA predisposing factors. We exploit the lack of overt OA in female STR/Ort and in both sexes of parental, control CBA mice to explore whether early divergence in tibial bone mass or shape are linked to emergent OA.

Citation

Javaheri, B., Razi, H., Piles, M., De Souza, R., Chang, Y. M., Maric-Mur, I., Hopkinson, M., Lee, P. D., & Pitsillides, A. A. (2018). Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice. Osteoarthritis and Cartilage, 26(6), 807-817. https://doi.org/10.1016/j.joca.2018.03.008

• Journal Article Type: Article
• Acceptance Date: Mar 19, 2018
• Publication Date: Mar 28, 2018
• Deposit Date: Apr 5, 2018
• Publicly Available Date: Apr 5, 2018
• Journal: Osteoarthritis and Cartilage
• Print ISSN: 1063-4584
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 26
• Issue: 6
• Pages: 807-817
• DOI: https://doi.org/10.1016/j.joca.2018.03.008
• Public URL: https://rvc-repository.worktribe.com/output/1387939