Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice

Javaheri, B; Razi, H; Piles, M; De Souza, R; Chang, Y M; Maric-Mur, I; Hopkinson, M; Lee, P D; Pitsillides, A A

doi:10.1016/j.joca.2018.03.008

Authors

B Javaheri

H Razi

M Piles

R De Souza

Y M Chang

I Maric-Mur

M Hopkinson

P D Lee

A A Pitsillides

Abstract

Human osteoarthritis (OA) is detected only at late stages. Male STR/Ort mice develop knee OA spontaneously with known longitudinal trajectory, offering scope to identify OA predisposing factors. We exploit the lack of overt OA in female STR/Ort and in both sexes of parental, control CBA mice to explore whether early divergence in tibial bone mass or shape are linked to emergent OA.

Citation

Javaheri, B., Razi, H., Piles, M., De Souza, R., Chang, Y. M., Maric-Mur, I., …Pitsillides, A. A. (2018). Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice. Osteoarthritis and Cartilage, 26(6), 807-817. https://doi.org/10.1016/j.joca.2018.03.008

Journal Article Type	Article
Acceptance Date	Mar 19, 2018
Publication Date	Mar 28, 2018
Deposit Date	Apr 5, 2018
Publicly Available Date	Nov 21, 2020
Journal	OSTEOARTHRITIS AND CARTILAGE
Print ISSN	1063-4584
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	26
Issue	6
Pages	807-817
DOI	https://doi.org/10.1016/j.joca.2018.03.008
Public URL	https://rvc-repository.worktribe.com/output/1387939