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Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice

Javaheri, B; Razi, H; Piles, M; De Souza, R; Chang, Y M; Maric-Mur, I; Hopkinson, M; Lee, P D; Pitsillides, A A

Authors

B Javaheri

H Razi

M Piles

R De Souza

Y M Chang

I Maric-Mur

M Hopkinson

P D Lee

A A Pitsillides



Abstract

Human osteoarthritis (OA) is detected only at late stages. Male STR/Ort mice develop knee OA spontaneously with known longitudinal trajectory, offering scope to identify OA predisposing factors. We exploit the lack of overt OA in female STR/Ort and in both sexes of parental, control CBA mice to explore whether early divergence in tibial bone mass or shape are linked to emergent OA.

Citation

Javaheri, B., Razi, H., Piles, M., De Souza, R., Chang, Y. M., Maric-Mur, I., …Pitsillides, A. A. (2018). Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice. Osteoarthritis and Cartilage, 26(6), 807-817. https://doi.org/10.1016/j.joca.2018.03.008

Journal Article Type Article
Acceptance Date Mar 19, 2018
Publication Date Mar 28, 2018
Deposit Date Apr 5, 2018
Publicly Available Date Mar 28, 2024
Journal OSTEOARTHRITIS AND CARTILAGE
Print ISSN 1063-4584
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 26
Issue 6
Pages 807-817
DOI https://doi.org/10.1016/j.joca.2018.03.008
Public URL https://rvc-repository.worktribe.com/output/1387939

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