Skip to main content

Research Repository

Advanced Search

Outputs (81)

VetCAST method for determination of the pharmacokineticpharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol Antimicrobial Susceptibility Testing in cattle (2019)
Journal Article
Toutain, P., Sidhu, P. K., Lees, P., Rassouli, A., & Pelligand, L. (2019). VetCAST method for determination of the pharmacokineticpharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol Antimicrobial Susceptibility Testing in cattle. Frontiers in Microbiology, 10(1310), https://doi.org/10.3389/fmicb.2019.01310

The PK/PD cut-off (PK/PDCO ) value of florfenicol for calf pathogens was determined for long acting formulations (MSD Nuflor® and a bioequivalent generic product). PK/PDCO is one of the three MICs considered by VetCAST, a sub-committee of the Europea... Read More about VetCAST method for determination of the pharmacokineticpharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol Antimicrobial Susceptibility Testing in cattle.

Semi-Mechanistic Modeling of Florfenicol Time-Kill Curves and in silico Dose Fractionation for Calf Respiratory Pathogens (2019)
Journal Article
Pelligand, L., Lees, P., Sidhu, P. K., & Toutain, P. (2019). Semi-Mechanistic Modeling of Florfenicol Time-Kill Curves and in silico Dose Fractionation for Calf Respiratory Pathogens. Frontiers in Microbiology, 10, https://doi.org/10.3389/fmicb.2019.01237

An important application of time-kill curve (TKC) assays is determination of the nature of the best PK/PD index (fAUC/MIC or fT% > MIC) and its target value for predicting clinical efficacy in vivo. VetCAST (the veterinary subcommittee of EUCAST) her... Read More about Semi-Mechanistic Modeling of Florfenicol Time-Kill Curves and in silico Dose Fractionation for Calf Respiratory Pathogens.

A double-blinded randomised dietary supplement crossover trial design to investigate the short-term influence of medium chain fatty acid (MCT) supplement on canine idiopathic epilepsy: study protocol (2019)
Journal Article
Berk, B. A., Packer, R. M. A., Law, T. H., Wessmann, A., Bathen-Nöthen, A., Jokinen, T. S., …Volk, H. A. (2019). A double-blinded randomised dietary supplement crossover trial design to investigate the short-term influence of medium chain fatty acid (MCT) supplement on canine idiopathic epilepsy: study protocol. BMC Veterinary Research, 15(181), https://doi.org/10.1186/s12917-019-1915-8

Faculty Perception of an Embedded Research Project in the Undergraduate Veterinary Curriculum (2019)
Journal Article
Cehrs, E., Pelligand, L., & Weller, R. (2019). Faculty Perception of an Embedded Research Project in the Undergraduate Veterinary Curriculum. Journal of Veterinary Medical Education,

In this article, we describe faculty’s perception of a research project embedded in the final year of the undergraduate veterinary curriculum and look at factors associated with overall perceptions of the project. We hypothesized that faculty would h... Read More about Faculty Perception of an Embedded Research Project in the Undergraduate Veterinary Curriculum.

Relating neuromuscular control to functional anatomy of limb muscles in extant archosaurs (2019)
Journal Article
Cuff, A. R., Daley, M. A., Michel, K. B., Allen, V. R., Lamas, L. P., Adami, C., …Hutchinson, J. R. (2019). Relating neuromuscular control to functional anatomy of limb muscles in extant archosaurs. Journal of Morphology, 280(5), 666-680. https://doi.org/10.1002/jmor.20973

Electromyography (EMG) is used to understand muscle activity patterns in animals. Understanding how much variation exists in muscle activity patterns in homologous muscles across animal clades during similar behaviours is important for evaluating the... Read More about Relating neuromuscular control to functional anatomy of limb muscles in extant archosaurs.

Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation (2018)
Journal Article
Martinez, M., Gehring, R., Mochel, J. P., Pade, D., & Pelligand, L. (2018). Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation. Journal of Veterinary Pharmacology and Therapeutics, 41(4), E-68. https://doi.org/10.1111/jvp.12666

During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the source... Read More about Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation.