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Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation

Martinez, M; Gehring, R; Mochel, J P; Pade, D; Pelligand, L

Authors

M Martinez

R Gehring

J P Mochel

D Pade

L Pelligand



Abstract

During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the sources of population variability. Part II provides a summary of discussions on modelling and simulation tools that utilize existing pharmacokinetic data, can integrate drug physicochemical characteristics with species physiological characteristics and dosing information or that combine observed with predicted and in vitro information to explore and describe sources of variability that may influence the safe and effective use of veterinary pharmaceuticals.

Citation

Martinez, M., Gehring, R., Mochel, J. P., Pade, D., & Pelligand, L. (2018). Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation. Journal of Veterinary Pharmacology and Therapeutics, 41(4), E-68. https://doi.org/10.1111/jvp.12666

Journal Article Type Article
Acceptance Date Apr 15, 2018
Publication Date May 28, 2018
Deposit Date Jul 24, 2018
Publicly Available Date Jul 24, 2018
Journal JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
Print ISSN 0140-7783
Publisher American Academy of Veterinary Pharmacology and Therapeutics
Peer Reviewed Peer Reviewed
Volume 41
Issue 4
Pages E-68
DOI https://doi.org/10.1111/jvp.12666
Public URL https://rvc-repository.worktribe.com/output/1387096

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