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Treatment of intrahepatic congenital portosystemic shunts in dogs: a systematic review (2017)
Journal Article
Tivers, M. S., Lipscomb, V. J., & Brockman, D. J. (2017). Treatment of intrahepatic congenital portosystemic shunts in dogs: a systematic review. Journal of Small Animal Practice, 58(9), 485-494. https://doi.org/10.1111/jsap.12712

The aim of this study was to establish the evidence base for the treatment of intrahepatic congenital portosystemic shunts in dogs through a systematic review of the pertinent literature. Studies were filtered for evidence to answer the question “Whi... Read More about Treatment of intrahepatic congenital portosystemic shunts in dogs: a systematic review.

Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat (2017)
Journal Article
Heaps, L. A., Scudder, C. J., Lipscomb, V. J., Steinbach, S. M. L., Priestnall, S. L., Martineau, H., Szladovits, B., Fowkes, R. C., & Garden, O. A. (2017). Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat. Journal of Feline Medicine and Surgery Open Reports, 32(2), https://doi.org/10.1177/2055116917722701

Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes (2017)
Journal Article
Jonas, K. C., Melrose, T., Thompson, I. R., Baxter, G. F., Lipscomb, V. J., Niessen, S. J. M., Lawson, C., McArdle, C. A., Roberson, M. S., McGonnell, I. M., Wheeler-Jones, C. P. D., & Fowkes, R. C. (2017). Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes. Cell and Tissue Research, 369(3), 567-578. https://doi.org/10.1007/s00441-017-2624-x

The natriuretic peptides, Atrial-, B-type and C-type natriuretric peptides (ANP, BNP, CNP), are regulators of many endocrine tissues and exert their effects predominantly through the activation of their specific guanylyl cyclase receptors (GC-A and G... Read More about Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes.

Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts (2015)
Journal Article
Tivers, M. S., Lipscomb, V. J., Smith, K. C., Wheeler-Jones, C. P. D., & House, A. K. (2015). Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts. https://doi.org/10.1016/j.tvjl.2015.07.006

Surgical attenuation of a congenital portosystemic shunt (CPSS) results in increased portal vein perfusion, liver growth and clinical improvement. Portal lipopolysaccharide (LPS) is implicated in liver regeneration via toll-like receptor (TLR) 4 medi... Read More about Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts.

Multiple acquired portosystemic shunts in a cat secondary to chronic diaphragmatic rupture (2015)
Journal Article
Barfield, D. M., Gibson, A. D., & Lipscomb, V. J. (2015). Multiple acquired portosystemic shunts in a cat secondary to chronic diaphragmatic rupture. Journal of Feline Medicine and Surgery Open Reports, 1(2), 1. https://doi.org/10.1177/2055116915585020

A cat with a chronic diaphragmatic rupture presented with neurological signs, including twitching and focal seizures. Blood ammonia level was markedly elevated and therefore neurological signs were thought to be related to hepatic encephalopathy. Exp... Read More about Multiple acquired portosystemic shunts in a cat secondary to chronic diaphragmatic rupture.

Attenuation of Congenital Portosystemic Shunt Reduces Inflammation in Dogs (2015)
Journal Article
Tivers, M. S., Handel, I., Gow, A. G., Lipscomb, V. J., Jalan, R., & Mellanby, R. J. (2015). Attenuation of Congenital Portosystemic Shunt Reduces Inflammation in Dogs. PLoS ONE, 10(2), https://doi.org/10.1371/journal.pone.0117557

Liver disease is a major cause of morbidity and mortality. One of the most significant complications in patients with liver disease is the development of neurological disturbances, termed hepatic encephalopathy. The pathogenesis of hepatic encephalop... Read More about Attenuation of Congenital Portosystemic Shunt Reduces Inflammation in Dogs.

Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes (2014)
Journal Article
Thompson, I. R., Mirczuk, S. M., Smith, L., Lessey, A. J., Simbi, B., Sunters, A., Baxter, G. F., Lipscomb, V. J., McGonnell, I. M., Wheeler-Jones, C. P. D., Mukherjee, A., Roberson, M. S., McArdle, C. A., & Fowkes, R. C. (2014). Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes. Cell and Tissue Research, 355(2), 425-36. https://doi.org/10.1007/s00441-013-1763-y

The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models... Read More about Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes.

Hyperammonemia and Systemic Inflammatory Response Syndrome Predicts Presence of Hepatic Encephalopathy in Dogs with Congenital Portosystemic Shunts (2014)
Journal Article
Tivers, M. S., Handel, I., Gow, A. G., Lipscomb, V. J., Jalan, R., & Mellanby, R. (2014). Hyperammonemia and Systemic Inflammatory Response Syndrome Predicts Presence of Hepatic Encephalopathy in Dogs with Congenital Portosystemic Shunts. PLoS ONE, 9(1), https://doi.org/10.1371/journal.pone.0082303

Hepatic encephalopathy (HE) is an important cause of morbidity and mortality in patients with liver disease. The pathogenesis of he is incompletely understood although ammonia and inflammatory cytokines have been implicated as key mediators. To facil... Read More about Hyperammonemia and Systemic Inflammatory Response Syndrome Predicts Presence of Hepatic Encephalopathy in Dogs with Congenital Portosystemic Shunts.