D P Blake
Exploring Eimeria Genomes to Understand Population Biology: Recent Progress and Future Opportunities
Blake, D P; Worthing, K; Jenkins, M C
Authors
K Worthing
M C Jenkins
Abstract
Eimeria, protozoan parasites from the phylum Apicomplexa, can cause the enteric disease coccidiosis in all farmed animals. Coccidiosis is commonly considered to be most significant in poultry; due in part to the vast number of chickens produced in the World each year, their short generation time, and the narrow profit margins associated with their production. Control of Eimeria has long been dominated by routine chemoprophylaxis, but has been supplemented or replaced by live parasite vaccination in a minority of production sectors. However, public and legislative demands for reduced drug use in food production is now driving dramatic change, replacing reliance on relatively indiscriminate anticoccidial drugs with vaccines that are Eimeria species-, and in some examples, strain-specific. Unfortunately, the consequences of deleterious selection on Eimeria population structure and genome evolution incurred by exposure to anticoccidial drugs or vaccines are unclear. Genome sequence assemblies were published in 2014 for all seven Eimeria species that infect chickens, stimulating the first population genetics studies for these economically important parasites. Here, we review current knowledge of eimerian genomes and highlight challenges posed by the discovery of new, genetically cryptic Eimeria operational taxonomic units (OTUs) circulating in chicken populations. As sequencing technologies evolve understanding of eimerian genomes will improve, with notable utility for studies of Eimeria biology, diversity and opportunities for control. View Full-Text
Citation
Blake, D. P., Worthing, K., & Jenkins, M. C. (2020). Exploring Eimeria Genomes to Understand Population Biology: Recent Progress and Future Opportunities. Genes, 11(9),
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 18, 2020 |
Publication Date | Sep 21, 2020 |
Deposit Date | Oct 13, 2020 |
Publicly Available Date | Oct 13, 2020 |
Journal | Genes |
Electronic ISSN | 2073-4425 |
Publisher | MDPI |
Peer Reviewed | Peer Reviewed |
Volume | 11 |
Issue | 9 |
Keywords | Eimeria, chickens, genetics, genome, population structure |
Public URL | https://rvc-repository.worktribe.com/output/1375603 |
Files
13087_GOLD.pdf
(888 Kb)
PDF
You might also like
First detection and characterisation of Eimeria zaria in Europe
(2023)
Journal Article
Downloadable Citations
About RVC Repository
Administrator e-mail: publicationsrepos@rvc.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search