Cellular and Cytokine Responses in the Granulomas of Asymptomatic Cattle naturally infected with

Tulu, B; Martineau, H M; Zewude, A; Desta, F; Jolliffe, D A; Abebe, M; Balcha, T T; Belay, M; Martineau, A R; Ameni, G

Abstract

Cells (CD3+ T cell and CD68+ macrophages), cytokines (IFN-γ+ and TNF-α+) and effector molecule (iNOS+) responses were evaluated in the lymph nodes and tissue of cattle naturally infected with Detailed post mortem and immunohistochemical examinations of lesions were performed on 16 cows positive for single intradermal cervical comparative tuberculin (SICCT) test which were identified from dairy farms located around the Addis Ababa City. The severity of the gross lesion was significantly higher (p=0.003) in culture positive (n=12) cows than in culture negative (n=4). Immunohistochemical techniques showed that in culture positive cows, the mean immunolabeling fraction of CD3+ T cells decreased as the stage of granuloma increased from stage I to stage IV (p

Citation

Tulu, B., Martineau, H. M., Zewude, A., Desta, F., Jolliffe, D. A., Abebe, M., …Ameni, G. (2020). Cellular and Cytokine Responses in the Granulomas of Asymptomatic Cattle naturally infected with. Infection and Immunity,

• Journal Article Type: Article
• Acceptance Date: Sep 21, 2020
• Publication Date: Sep 21, 2020
• Deposit Date: Oct 7, 2020
• Publicly Available Date: Oct 7, 2020
• Journal: Infection and immunity
• Print ISSN: 0019-9567
• Publisher: American Society for Microbiology
• Peer Reviewed: Peer Reviewed
• Public URL: https://rvc-repository.worktribe.com/output/1375621