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Mitochondria Regulate Inflammatory Paracrine Signalling in Neurodegeneration.

Faccenda, D; Campanella, M


D Faccenda

M Campanella


Mitochondrial dysfunction occurs in most neurodegenerative diseases, contributing to both their onset and progression. A recent breakthrough unveiled that propagation of the inflammatory response and subsequent neuronal injury are also mediated extracellularly by damaged mitochondria, which are released from active microglial cells into the brain milieu. These extracellular fragmented mitochondria can therefore generate sufficient toxicity to trigger neuronal death and widespread brain damage through activation of naïve astrocytes. Besides suggesting potential new pharmacological strategies of therapeutic intervention in neurodegeneration, this original work indicates that mitochondria might act as bioactive ligands exerting paracrine functions. This is an interesting, novel and impactful concept that deserves consideration by the scientific community, as the attention should now be focused on the identification of the specific receptors through which mitochondria mediate such an important extracellular signalling mechanism in neurological conditions.


Faccenda, D., & Campanella, M. (2020). Mitochondria Regulate Inflammatory Paracrine Signalling in Neurodegeneration. Journal of Neuroimmune Pharmacology,

Journal Article Type Letter
Acceptance Date Aug 17, 2020
Publication Date Sep 11, 2020
Deposit Date Oct 2, 2020
Journal Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Print ISSN 1557-1890
Publisher Springer
Peer Reviewed Peer Reviewed
Keywords Extracellular signalling, Mitochondria, Neurodegeneration
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