Mitochondria Regulate Inflammatory Paracrine Signalling in Neurodegeneration.

Faccenda, D; Campanella, M

Abstract

Mitochondrial dysfunction occurs in most neurodegenerative diseases, contributing to both their onset and progression. A recent breakthrough unveiled that propagation of the inflammatory response and subsequent neuronal injury are also mediated extracellularly by damaged mitochondria, which are released from active microglial cells into the brain milieu. These extracellular fragmented mitochondria can therefore generate sufficient toxicity to trigger neuronal death and widespread brain damage through activation of naïve astrocytes. Besides suggesting potential new pharmacological strategies of therapeutic intervention in neurodegeneration, this original work indicates that mitochondria might act as bioactive ligands exerting paracrine functions. This is an interesting, novel and impactful concept that deserves consideration by the scientific community, as the attention should now be focused on the identification of the specific receptors through which mitochondria mediate such an important extracellular signalling mechanism in neurological conditions.

Citation

Faccenda, D., & Campanella, M. (2020). Mitochondria Regulate Inflammatory Paracrine Signalling in Neurodegeneration. Journal of Neuroimmune Pharmacology,

• Journal Article Type: Letter
• Acceptance Date: Aug 17, 2020
• Publication Date: Sep 11, 2020
• Deposit Date: Oct 2, 2020
• Journal: Journal of Neuroimmune Pharmacology
• Print ISSN: 1557-1890
• Electronic ISSN: 1557-1904
• Publisher: Springer
• Peer Reviewed: Peer Reviewed
• Keywords: Extracellular signalling, Mitochondria, Neurodegeneration
• Public URL: https://rvc-repository.worktribe.com/output/1375853