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Biomarker changes with systolic anterior motion of the mitral valve in cats with hypertrophic cardiomyopathy

Seo, J; Payne, J R; Novo Matos, J; Fong, W W; Connolly, D J; Luis Fuentes, V


J Seo

J R Payne

J Novo Matos

W W Fong

D J Connolly

V Luis Fuentes



N‐terminal pro B‐type natriuretic peptide (NT‐proBNP) and cardiac troponin‐I (cTnI) are biomarkers commonly evaluated in cats with suspected heart disease. Many cats with hypertrophic cardiomyopathy (HCM) have systolic anterior motion of the mitral valve (SAM), but its influence on circulating NT‐proBNP or cTnI concentrations is currently unknown.


Cats with HCM and SAM (HCMSAM+) have higher NT‐proBNP and cTnI concentrations than do cats with HCM but without SAM (HCMSAM−).


One hundred forty cats with HCM: 70 with SAM and 70 without SAM.


Retrospective case‐to‐case study. Cats were recruited if diagnosed with HCM by echocardiography and results were available for NT‐proBNP or cTnI concentrations or both. Cats with SAM were matched to those without SAM for clinical presentation, left atrial (LA) size and left ventricular (LV) fractional shortening.


A total of 119 NT‐proBNP and 123 cTnI results were available. The HCMSAM+ cats had higher median concentrations than did HCMSAM− cats for NT‐proBNP (729 pmoL/L; interquartile range [IQR], 275‐1467 versus 65 pmoL/L; IQR, 25‐271; P 


Seo, J., Payne, J. R., Novo Matos, J., Fong, W. W., Connolly, D. J., & Luis Fuentes, V. (2020). Biomarker changes with systolic anterior motion of the mitral valve in cats with hypertrophic cardiomyopathy. Journal of Veterinary Internal Medicine,

Journal Article Type Article
Acceptance Date May 6, 2020
Publication Date Aug 21, 2020
Deposit Date Sep 7, 2020
Publicly Available Date Sep 7, 2020
Journal Journal of Veterinary Internal Medicine
Print ISSN 0891-6640
Publisher Wiley Open Access
Peer Reviewed Peer Reviewed
Public URL
Publisher URL


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