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Vaccination with transgenic Eimeria tenella expressing Eimeria maxima AMA1 and IMP1 confers partial protection against high level E. maxima challenge in a broiler model of coccidiosis.

Pastor-Fernández, I; Sungwon, K; Marugán-Hernández, V; Soutter, F; Tomley, F; Blake, D

Authors

I Pastor-Fernández

K Sungwon

V Marugán-Hernández

F Soutter

F Tomley

D Blake



Abstract

Poultry coccidiosis is a parasitic enteric disease with a highly negative impact on chicken production. In-feed chemoprophylaxis remains the primary method of control, but the increasing ineffectiveness of anticoccidial drugs, and potential future restrictions on their use has encouraged the use of commercial live vaccines. Availability of such formulations is constrained by their production, which relies on the use of live chickens. Several experimental approaches have been taken to explore ways to reduce the complexity and cost of current anticoccidial vaccines including the use of live vectors expressing relevant Eimeria proteins. We and others have shown that vaccination with transgenic Eimeria tenella parasites expressing E. maxima Apical Membrane Antigen-1 or Immune Mapped Protein-1 (EmAMA1 and EmIMP1) partially reduces parasite replication after challenge with a low dose of E. maxima oocysts. In the present work we have reassessed the efficacy of these experimental vaccines using commercial birds reared at high stocking densities and challenged with both low and high doses of E. maxima to evaluate how well they protect chickens against the negative impacts of disease on production parameters.

Citation

Pastor-Fernández, I., Sungwon, K., Marugán-Hernández, V., Soutter, F., Tomley, F., & Blake, D. (2020). Vaccination with transgenic Eimeria tenella expressing Eimeria maxima AMA1 and IMP1 confers partial protection against high level E. maxima challenge in a broiler model of coccidiosis. Parasites and Vectors,

Journal Article Type Article
Acceptance Date Jun 11, 2020
Publication Date Jul 10, 2020
Deposit Date Jun 17, 2020
Publicly Available Date Dec 9, 2020
Journal Parasites and Vectors
Electronic ISSN 1756-3305
Publisher BioMed Central
Peer Reviewed Peer Reviewed
Public URL https://rvc-repository.worktribe.com/output/1377101
Publisher URL https://parasitesandvectors.biomedcentral.com/

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