I Pastor-Fernández
Vaccination with transgenic Eimeria tenella expressing Eimeria maxima AMA1 and IMP1 confers partial protection against high level E. maxima challenge in a broiler model of coccidiosis.
Pastor-Fernández, I; Sungwon, K; Marugán-Hernández, V; Soutter, F; Tomley, F; Blake, D
Authors
K Sungwon
V Marugán-Hernández
F Soutter
F Tomley
D Blake
Abstract
Poultry coccidiosis is a parasitic enteric disease with a highly negative impact on chicken production. In-feed chemoprophylaxis remains the primary method of control, but the increasing ineffectiveness of anticoccidial drugs, and potential future restrictions on their use has encouraged the use of commercial live vaccines. Availability of such formulations is constrained by their production, which relies on the use of live chickens. Several experimental approaches have been taken to explore ways to reduce the complexity and cost of current anticoccidial vaccines including the use of live vectors expressing relevant Eimeria proteins. We and others have shown that vaccination with transgenic Eimeria tenella parasites expressing E. maxima Apical Membrane Antigen-1 or Immune Mapped Protein-1 (EmAMA1 and EmIMP1) partially reduces parasite replication after challenge with a low dose of E. maxima oocysts. In the present work we have reassessed the efficacy of these experimental vaccines using commercial birds reared at high stocking densities and challenged with both low and high doses of E. maxima to evaluate how well they protect chickens against the negative impacts of disease on production parameters.
Citation
Pastor-Fernández, I., Sungwon, K., Marugán-Hernández, V., Soutter, F., Tomley, F., & Blake, D. (2020). Vaccination with transgenic Eimeria tenella expressing Eimeria maxima AMA1 and IMP1 confers partial protection against high level E. maxima challenge in a broiler model of coccidiosis. Parasites and Vectors,
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 11, 2020 |
Publication Date | Jul 10, 2020 |
Deposit Date | Jun 17, 2020 |
Publicly Available Date | Dec 9, 2020 |
Journal | Parasites and Vectors |
Electronic ISSN | 1756-3305 |
Publisher | BioMed Central |
Peer Reviewed | Peer Reviewed |
Public URL | https://rvc-repository.worktribe.com/output/1377101 |
Publisher URL | https://parasitesandvectors.biomedcentral.com/ |
Files
vor
(1.6 Mb)
PDF
Licence
http://creativecommons.org/licenses/by/4.0/
Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/
You might also like
Canine tick-borne pathogens in Cyprus and a unique canine case of multiple co-infections
(2017)
Journal Article
Poultry Coccidiosis: Design and Interpretation of Vaccine Studies
(2020)
Journal Article
Downloadable Citations
About RVC Repository
Administrator e-mail: publicationsrepos@rvc.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search