A systematic review on integration mechanisms in human and animal health surveillance systems with a view to addressing global health security threats

George, J; Häsler, B; Mremi, I; Sindato, C; Mboera, L; Rweyemamu, M; Mlangwa, J

Authors

J George

B Häsler

I Mremi

C Sindato

L Mboera

M Rweyemamu

J Mlangwa

Abstract

Lymphatic filariasis and onchocerciasis are neglected tropical diseases (NTDs) targeted for elimination by mass (antifilarial) drug administration. These drugs are predominantly active against the microfilarial progeny of adult worms. New drugs or combinations are needed to improve patient therapy and to enhance the effectiveness of interventions in persistent hotspots of transmission. Several therapies and regimens are currently in (pre-)clinical testing. Clinical trial simulators (CTSs) project patient outcomes to inform the design of clinical trials but have not been widely applied to NTDs, where their resource-saving payoffs could be highly beneficial. We demonstrate the utility of CTSs using our individual-based onchocerciasis transmission model (EPIONCHO-IBM) that projects trial outcomes of a hypothetical macrofilaricidal drug. We identify key design decisions that influence the power of clinical trials, including participant eligibility criteria and post-treatment follow-up times for measuring infection indicators. We discuss how CTSs help to inform target product profiles.

Citation

George, J., Häsler, B., Mremi, I., Sindato, C., Mboera, L., Rweyemamu, M., & Mlangwa, J. (2020). A systematic review on integration mechanisms in human and animal health surveillance systems with a view to addressing global health security threats. One Health Outlook, 2(1),

Journal Article Type	Article
Acceptance Date	May 5, 2020
Publication Date	Jun 1, 2020
Deposit Date	Jun 16, 2020
Publicly Available Date	Nov 20, 2020
Journal	One Health Outlook
Print ISSN	2524-4655
Publisher	BioMed Central
Peer Reviewed	Peer Reviewed
Volume	2
Issue	1
Public URL	https://rvc-repository.worktribe.com/output/1377163
Publisher URL	https://doi.org/10.1186/s42522-020-00017-4