Lasting organ-level bone mechanoadaptation is unrelated to local strain

Javaheri, B; Razi, H; Gohin, S; Wylie, S; Chang, Y M; Salmon, P; Lee, P D; Pitsillides, A A

Abstract

Bones adapt to mechanical forces according to strict principles predicting straight shape. Most bones are, however, paradoxically curved. To solve this paradox, we used computed tomography–based, four-dimensional imaging methods and computational analysis to monitor acute and chronic whole-bone shape adaptation and remodeling in vivo. We first confirmed that some acute load-induced structural changes are reversible, adhere to the linear strain magnitude regulation of remodeling activities, and are restricted to bone regions in which marked antiresorptive actions are evident. We make the novel observation that loading exerts significant lasting modifications in tibial shape and mass across extensive bone regions, underpinned by (re)modeling independent of local strain magnitude, occurring at sites where the initial response to load is principally osteogenic. This is the first report to demonstrate that bone loading stimulates nonlinear remodeling responses to strain that culminate in greater curvature adjusted for load predictability without sacrificing strength.

Citation

Javaheri, B., Razi, H., Gohin, S., Wylie, S., Chang, Y. M., Salmon, P., …Pitsillides, A. A. (2020). Lasting organ-level bone mechanoadaptation is unrelated to local strain. Science Advances, 6(10), https://doi.org/10.1126/sciadv.aax8301

• Journal Article Type: Article
• Acceptance Date: Dec 13, 2019
• Publication Date: Mar 6, 2020
• Deposit Date: Mar 10, 2020
• Publicly Available Date: Mar 10, 2020
• Journal: Science Advances
• Publisher: American Association for the Advancement of Science
• Peer Reviewed: Peer Reviewed
• Volume: 6
• Issue: 10
• DOI: https://doi.org/10.1126/sciadv.aax8301
• Public URL: https://rvc-repository.worktribe.com/output/1378285