Skip to main content

Research Repository

Advanced Search

Assessing pathological changes within the nucleus ambiguus of horses with Recurrent Laryngeal Neuropathy: an extreme, length-dependent axonopathy

Draper, A C E; Cahalan, S D; Goodwin, D; Perkins, J D M; Piercy, R J

Authors

A C E Draper

S D Cahalan

D Goodwin

J D M Perkins

R J Piercy



Abstract

Equine recurrent laryngeal neuropathy (RLN) is a naturally occurring model of length‐dependent axonopathy characterised by asymmetrical degeneration of recurrent laryngeal nerve axons (RLn). Distal RLn degeneration is marked, however it is unclear whether degeneration extends to include cell bodies (consistent with a neuronopathy).
With examiners blinded to RLN severity, brainstem location and side, we examined correlations between RLN severity (assessed using left distal RLn myelinated axon count) and histopathological features (including chromatolysis and glial responses) in the nucleus ambiguus cell bodies, and myelinated axon count of the right distal RLn of 16 horses.

Citation

Draper, A. C. E., Cahalan, S. D., Goodwin, D., Perkins, J. D. M., & Piercy, R. J. (2019). Assessing pathological changes within the nucleus ambiguus of horses with Recurrent Laryngeal Neuropathy: an extreme, length-dependent axonopathy. Muscle & Nerve, https://doi.org/10.1002/mus.26699

Journal Article Type Article
Acceptance Date Sep 3, 2019
Publication Date Sep 9, 2019
Deposit Date Sep 11, 2019
Publicly Available Date Sep 15, 2020
Journal MUSCLE & NERVE
Print ISSN 0148-639X
Electronic ISSN 1097-4598
Publisher Wiley
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1002/mus.26699
Public URL https://rvc-repository.worktribe.com/output/1380529

Files





You might also like



Downloadable Citations