Urinary peptidome analyses for the diagnosis of chronic kidney disease in dogs

Pelander, L; Brunchault, V; Buffin-Meyer, B; Klein, J; Breuil, B; Zürbig, P; Magalhães, P; Mullen, W; Elliott, J; Syme, H M; Schanstra, J P; Häggström, J; Ljungvall, I

Abstract

Chronic kidney disease (CKD) is clinically important in canine medicine. Current diagnostic tools lack sensitivity for detection of subclinical CKD. The aim of the present study was to evaluate urinary peptidome analysis for diagnosis of CKD in dogs. Capillary electrophoresis coupled to mass spectrometry analysis demonstrated presence of approximately 5400 peptides in dog urine. Comparison of urinary peptide abundance of dogs with and without CKD led to the identification of 133 differentially excreted peptides (adjusted P for each peptide

Citation

Pelander, L., Brunchault, V., Buffin-Meyer, B., Klein, J., Breuil, B., Zürbig, P., Magalhães, P., Mullen, W., Elliott, J., Syme, H. M., Schanstra, J. P., Häggström, J., & Ljungvall, I. (2019). Urinary peptidome analyses for the diagnosis of chronic kidney disease in dogs. https://doi.org/10.1016/j.tvjl.2019.05.010

• Journal Article Type: Article
• Acceptance Date: May 26, 2019
• Publication Date: Jul 1, 2019
• Deposit Date: Jun 22, 2019
• Publicly Available Date: Jun 24, 2019
• Journal: VETERINARY JOURNAL
• Peer Reviewed: Peer Reviewed
• Volume: 249
• Pages: 73-79
• DOI: https://doi.org/10.1016/j.tvjl.2019.05.010
• Public URL: https://rvc-repository.worktribe.com/output/1381447